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Gene Review: 

Vps45  -  vacuolar protein sorting 45 (yeast)

Mus musculus

Synonyms: AI462172, AW554165, Vacuolar protein sorting-associated protein 45, Vps45a, mVps45
 
 
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High impact information on Vps45

  • We found that mVps45 is a ubiquitously expressed peripheral membrane protein that localized to perinuclear Golgi-like and trans-Golgi network compartments in Chinese hamster ovary cells [1].
  • At the nucleotide sequence level h1Vps45 demonstrated 90% homology to the hVps45 and rVps45 and 89% identity to mVps45 with no significant homology in their noncoding regions [2].
  • Although the deduced amino acid (AA) sequence of this cDNA has revealed 97% identity to other known mammalian vacuolar protein sorting, there is an extensive variation in nucleotide sequence in comparison to that of three previously reported human (hVps45), rat (rVps45) and mouse (mVps45) vacuolar protein sorting (Vps45) cDNAs [1-3] [2].
  • Genetic mapping of vacuolar protein sorting-45 (Vps45) on mouse chromosome 3 [3].

References

  1. Identification of a mammalian Golgi Sec1p-like protein, mVps45. Tellam, J.T., James, D.E., Stevens, T.H., Piper, R.C. J. Biol. Chem. (1997) [Pubmed]
  2. Molecular cloning and characterization of a cDNA encoding the human leucocyte vacuolar protein sorting (h1Vps45). Rajasekariah, P., Eyre, H.J., Stanley, K.K., Walls, R.S., Sutherland, G.R. Int. J. Biochem. Cell Biol. (1999) [Pubmed]
  3. Genetic mapping of vacuolar protein sorting-45 (Vps45) on mouse chromosome 3. Mishra, V.S., Holt, S.M., Teodoro, J.M., Kingsmore, S.F. Mamm. Genome (1998) [Pubmed]
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