Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene: FGF12 - fibroblast growth factor 12

Homo sapiens

Synonyms: FGF-12, FGF12B, FHF1, FHF-1, Fibroblast growth factor 12, Fibroblast growth factor homologous factor 1, Myocyte-activating factor

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Liu, C.J., Abriel, H., Gecz, J., Coll-Fresno, P.M., Modamio-Høybjør, S., et al.

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Disease relevance of FGF12

The FGFs constitute a family of, at least, 12 polypeptides (FGF1 to FGF12) implicated in a number of physiological and pathological processes throughout embryogenesis and adult life [1].

High impact information on FGF12

We have previously shown that fibroblast growth factor homologous factor 1B (FHF1B), a cytosolic member of the fibroblast growth factor family, associates with the sensory neuron-specific channel Na(v)1.9 but not with the other sodium channels present in adult rat dorsal root ganglia neurons [2].
Modulation of the cardiac sodium channel Nav1.5 by fibroblast growth factor homologous factor 1B [2].
Heteroduplex analysis and DNA sequencing of coding regions and exon/intron boundaries of two genes (CLDN16 and FGF12) in this interval did not reveal disease-causing mutations [3].
Database searches and analysis of available genomic DNA sequence from the region revealed the presence of the fibroblast growth factor homologous factor gene, FHF2, within the duplication breakpoint interval [4].
Chromosomal mapping of two novel human FGF genes, FGF11 and FGF12 [5].

Biological context of FGF12

Assignment of FGF12, the human FGF homologous factor 1 gene, to chromosome 3q29-->3qter by fluorescence in situ hybridization [6].

Other interactions of FGF12

This review focuses on five intracellular proteins that have been recently reported to directly bind to and contribute to the regulation of Na(v)1.5: ankyrin proteins, fibroblast growth factor homologous factor 1B, calmodulin, Nedd4-like ubiquitin-protein ligases, and syntrophin proteins [7].
Several genes, including fibroblast growth factor receptor 3, fibroblast growth factor 12 and CD4 were down-regulated on the different surfaces [8].

References

Cytotoxic activity of a diptheria toxin/FGF6 mitotoxin on human tumour cell lines. Coll-Fresno, P.M., Batoz, M., Tarquin, S., Birnbaum, D., Coulier, F. Oncogene (1997)
Modulation of the cardiac sodium channel Nav1.5 by fibroblast growth factor homologous factor 1B. Liu, C.J., Dib-Hajj, S.D., Renganathan, M., Cummins, T.R., Waxman, S.G. J. Biol. Chem. (2003)
A novel locus for autosomal dominant nonsyndromic hearing loss (DFNA44) maps to chromosome 3q28-29. Modamio-Høybjør, S., Moreno-Pelayo, M.A., Mencía, A., del Castillo, I., Chardenoux, S., Armenta, D., Lathrop, M., Petit, C., Moreno, F. Hum. Genet. (2003)
Fibroblast growth factor homologous factor 2 (FHF2): gene structure, expression and mapping to the Börjeson-Forssman-Lehmann syndrome region in Xq26 delineated by a duplication breakpoint in a BFLS-like patient. Gecz, J., Baker, E., Donnelly, A., Ming, J.E., McDonald-McGinn, D.M., Spinner, N.B., Zackai, E.H., Sutherland, G.R., Mulley, J.C. Hum. Genet. (1999)
Chromosomal mapping of two novel human FGF genes, FGF11 and FGF12. Verdier, A.S., Mattei, M.G., Lovec, H., Hartung, H., Goldfarb, M., Birnbaum, D., Coulier, F. Genomics (1997)
Assignment of FGF12, the human FGF homologous factor 1 gene, to chromosome 3q29-->3qter by fluorescence in situ hybridization. Liu, Y., Chiu, I.M. Cytogenet. Cell Genet. (1997)
Regulation of the voltage-gated cardiac sodium channel Nav1.5 by interacting proteins. Abriel, H., Kass, R.S. Trends Cardiovasc. Med. (2005)
Biological responses in osteoblast-like cell line according to thin layer hydroxyapatite coatings on anodized titanium. Sohn, S.H., Jun, H.K., Kim, C.S., Kim, K.N., Chung, S.M., Shin, S.W., Ryu, J.J., Kim, M.K. Journal of oral rehabilitation (2006)