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Ywhaz  -  tyrosine 3-monooxygenase/tryptophan 5...

Mus musculus

Synonyms: 1110013I11Rik, 14-3-3 protein zeta/delta, 14-3-3 zeta, 14-3-3zeta, AI596267, ...
 
 
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Disease relevance of Ywhaz

  • Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells [1].
 

High impact information on Ywhaz

  • Unlike ADP- or thrombin-induced PA, BL6 cell-induced PA was not inhibited by Calphostin-C (a potent protein kinase C inhibitor) or cilostazol (a potent inhibitor of PA based on inhibition of cyclic AMP phosphodiesterase) [2].
  • Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells [3].
  • The PGN-induced increase in kappaB luciferase activity was inhibited by NS398, AH6809, AH23848, KT5720, a protein kinase C inhibitor (Ro31-8220), and a p38 MAPK inhibitor (SB203580) [4].
  • Golgi kinase activity was strongly inhibited by the broad-range kinase inhibitor staurosporine and partially inhibited by the protein kinase C inhibitor bisindolylmaleimide I, but not by the other protein kinase A, Ca2+/calmodulin-dependent kinase II, myosin light chain kinase, and protein kinase G inhibitors tested [5].
  • Treatment of these cells with c-fos antisense DNA or protein kinase C inhibitor inhibited the stimulatory effect of glucose on LPL mRNA expression [6].
 

Biological context of Ywhaz

 

Anatomical context of Ywhaz

 

Associations of Ywhaz with chemical compounds

  • In the first, the effects of rIFN-gamma and rIL-1 alpha on cytoplasmic pH were measured in the presence of a protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine, H-7 [13].
  • The potent protein kinase C inhibitor, H7, also inhibited IL-1-mediated responses, while HA1004, a weak inhibitor of protein kinase C, did not [14].
  • This phorbol 12,13-dibutyrate antagonism of N(2)O-induced antinociception was reversed by i.c.v. pretreatment with calphostin C, a protein kinase C inhibitor [15].
  • Similar to tenascin-C, immobilized antibody to GD2 (3F8) or sphingosine, a protein kinase C inhibitor, strongly inhibited RGD-dependent cell spreading [16].
  • We have previously shown that chronic (18 h) but not acute (30 min or 2 h) pretreatment with the muscarinic receptor agonist carbachol resulted in decreased adenylyl cyclase activity in response to GTP, isoproterenol, or forskolin via a pathway blocked by the protein kinase C inhibitor staurosporine [17].
  • In whole cell extracts from MN9D cells after 14-3-3 small interfering RNA treatments, we found that 14-3-3zeta knockdown significantly reduced TH activity and dopamine synthesis whereas knockdown of 14-3-3eta had no effect [18].
 

Other interactions of Ywhaz

References

  1. Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells. Ikegami, Y., Yano, S., Nakao, K. Jpn. J. Pharmacol. (1996) [Pubmed]
  2. Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation. Okoshi, H., Hakomori, S., Nisar, M., Zhou, Q.H., Kimura, S., Tashiro, K., Igarashi, Y. Cancer Res. (1991) [Pubmed]
  3. Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells. Sako, T., Tauber, A.I., Jeng, A.Y., Yuspa, S.H., Blumberg, P.M. Cancer Res. (1988) [Pubmed]
  4. Peptidoglycan-induced IL-6 production in RAW 264.7 macrophages is mediated by cyclooxygenase-2, PGE2/PGE4 receptors, protein kinase A, I kappa B kinase, and NF-kappa B. Chen, B.C., Liao, C.C., Hsu, M.J., Liao, Y.T., Lin, C.C., Sheu, J.R., Lin, C.H. J. Immunol. (2006) [Pubmed]
  5. Neuroendocrine protein 7B2 can be inactivated by phosphorylation within the secretory pathway. Lee, S.N., Hwang, J.R., Lindberg, I. J. Biol. Chem. (2006) [Pubmed]
  6. Stimulatory effect of glucose on macrophage lipoprotein lipase expression and production. Sartippour, M.R., Lambert, A., Laframboise, M., St-Jacques, P., Renier, G. Diabetes (1998) [Pubmed]
  7. Expression of stage-specific genes during zygotic gene activation in preimplantation mouse embryos. Li, W., Zhang, J., Yu, W., Liu, G., Chen, Q. Zool. Sci. (2003) [Pubmed]
  8. Human IL-3 receptor signaling: rapid induction of phosphatidylcholine hydrolysis is independent of protein kinase C but dependent on tyrosine phosphorylation in transfected NIH 3T3 cells. Rao, P., Kitamura, T., Miyajima, A., Mufson, R.A. J. Immunol. (1995) [Pubmed]
  9. Phorbol myristate acetate-induced down-modulation of CD4 is dependent on calmodulin and intracellular calcium. Bigby, M., Wang, P., Fierro, J.F., Sy, M.S. J. Immunol. (1990) [Pubmed]
  10. Enhanced gene expression of the murine ecotropic retroviral receptor and its human homolog in proliferating cells. Yoshimoto, T., Yoshimoto, E., Meruelo, D. J. Virol. (1992) [Pubmed]
  11. Staurosporine induces tyrosine phosphorylation of a 145 kDa protein but does not activate gp140trk in PC12 cells. Rasouly, D., Lazarovici, P. Eur. J. Pharmacol. (1994) [Pubmed]
  12. CD99 monoclonal antibody induce homotypic adhesion of Jurkat cells through protein tyrosine kinase and protein kinase C-dependent pathway. Kasinrerk, W., Tokrasinwit, N., Moonsom, S., Stockinger, H. Immunol. Lett. (2000) [Pubmed]
  13. Interferon-gamma and interleukin-1 alpha induce transient translocation of protein kinase C activity to membranes in a B lymphoid cell line. Evidence for a protein kinase C-independent pathway in lymphokine-induced cytoplasmic alkalinization. Ostrowski, J., Meier, K.E., Stanton, T.H., Smith, L.L., Bomsztyk, K. J. Biol. Chem. (1988) [Pubmed]
  14. Synthetic peptide corresponding to a conserved domain of the retroviral protein p15E blocks IL-1-mediated signal transduction. Gottlieb, R.A., Lennarz, W.J., Knowles, R.D., Cianciolo, G.J., Dinarello, C.A., Lachman, L.B., Kleinerman, E.S. J. Immunol. (1989) [Pubmed]
  15. Involvement of brain protein kinase C in nitrous oxide-induced antinociception in mice. Ishikawa, M., Matsushita, Y., Abe, K., Utsunomiya, I., Hoshi, K., Quock, R.M., Taguchi, K. Neuroscience (2006) [Pubmed]
  16. Tenascin-C inhibits beta1 integrin-dependent cell adhesion and neurite outgrowth on fibronectin by a disialoganglioside-mediated signaling mechanism. Probstmeier, R., Pesheva, P. Glycobiology (1999) [Pubmed]
  17. Decreased adenylyl cyclase protein and function in airway smooth muscle by chronic carbachol pretreatment. Emala, C.W., Clancy-Keen, J., Hirshman, C.A. Am. J. Physiol., Cell Physiol. (2000) [Pubmed]
  18. 14-3-3zeta contributes to tyrosine hydroxylase activity in MN9D cells: localization of dopamine regulatory proteins to mitochondria. Wang, J., Lou, H., Pedersen, C.J., Smith, A.D., Perez, R.G. J. Biol. Chem. (2009) [Pubmed]
 
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