Disease relevance of Gca

• While marginally increased survival rates of mutants faced with endotoxic shock may indicate a contribution of grancalcin to immunopathogenesis, it is not essential for vital leukocyte effector functions required to control microbial infections [1].
• Characterization of murine grancalcin specifically expressed in leukocytes and its possible role in host defense against bacterial infection [2].

High impact information on Gca

• Leukocyte recruitment into the peritoneal cavity upon induction of inflammation was not significantly affected by the absence of grancalcin [1].
• Granulocyte function in grancalcin-deficient mice [1].
• Grancalcin, one of the penta-EF-hand Ca(2+) binding proteins, is expressed at high levels in polymorphonuclear granulocytes (neutrophils) [1].
• Most importantly, the conformation of des1-20ALG-2 is significantly different from that of calpain and grancalcin [3].
• A flow cytometric analysis revealed grancalcin to be highly expressed in macrophages and neutrophils [2].

Biological context of Gca

• In the related proteins calpain and grancalcin, the EF5 does not bind Ca2+ and is thought to primarily facilitate dimerization [3].

Associations of Gca with chemical compounds

• Immunohistochemical studies clarified that grancalcin was translocated to the actin cytoskeleton in macrophages upon exposure to bacterial lipopolysaccharide [2].

References