Gene Review:
FKBP1B - FK506 binding protein 1B, 12.6 kDa
Homo sapiens
Synonyms:
12.6 kDa FK506-binding protein, 12.6 kDa FKBP, FK506-binding protein 1B, FKBP-12.6, FKBP-1B, ...
- Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6. George, C.H., Higgs, G.V., Mackrill, J.J., Lai, F.A. J. Biol. Chem. (2003)
- A novel mutation in FKBP12.6 binding region of the human cardiac ryanodine receptor gene (R2401H) in a Japanese patient with catecholaminergic polymorphic ventricular tachycardia. Aizawa, Y., Ueda, K., Komura, S., Washizuka, T., Chinushi, M., Inagaki, N., Matsumoto, Y., Hayashi, T., Takahashi, M., Nakano, N., Yasunami, M., Kimura, A., Hiraoka, M., Aizawa, Y. International journal of cardiology. (2005)
- The inotropic adaptation during late preconditioning against myocardial stunning is associated with an increase in FKBP12.6. Lucats, L., Vinet, L., Bizé, A., Monnet, X., Morin, D., Su, J.B., Rouet-Benzineb, P., Cazorla, O., Mercadier, J.J., Hittinger, L., Berdeaux, A., Ghaleh, B. Cardiovasc. Res. (2007)
- Synthesis in Escherichia coli of two smaller enzymically active analogues of Coxiella burnetii macrophage infectivity potentiator (CbMip) protein utilizing a single open reading frame from the cbmip gene. Mo, Y.Y., Seshu, J., Wang, D., Mallavia, L.P. Biochem. J. (1998)
- Three-dimensional visualization of FKBP12.6 binding to an open conformation of cardiac ryanodine receptor. Sharma, M.R., Jeyakumar, L.H., Fleischer, S., Wagenknecht, T. Biophys. J. (2006)
- PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Marx, S.O., Reiken, S., Hisamatsu, Y., Jayaraman, T., Burkhoff, D., Rosemblit, N., Marks, A.R. Cell (2000)
- Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins. Fischer, G., Wittmann-Liebold, B., Lang, K., Kiefhaber, T., Schmid, F.X. Nature (1989)
- The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. Shen, M., Stukenberg, P.T., Kirschner, M.W., Lu, K.P. Genes Dev. (1998)
- Presence of cyclophilin A in synovial fluids of patients with rheumatoid arthritis. Billich, A., Winkler, G., Aschauer, H., Rot, A., Peichl, P. J. Exp. Med. (1997)
- Peptidyl-prolyl cis-trans isomerase of Bacillus subtilis: identification of residues involved in cyclosporin A affinity and catalytic efficiency. Göthel, S.F., Herrler, M., Marahiel, M.A. Biochemistry (1996)
- Evidence of association between FKBP1B and thyroid autoimmune disorders in a large Tunisian family. Maalej, A., Mbarki, F., Rebai, A., Karray, F., Jouida, J., Abid, M., Ayadi, H. Autoimmunity (2004)
- Localization of the 12.6-kDa FK506-binding protein (FKBP12.6) binding site to the NH2-terminal domain of the cardiac Ca2+ release channel (ryanodine receptor). Masumiya, H., Wang, R., Zhang, J., Xiao, B., Chen, S.R. J. Biol. Chem. (2003)
- A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. Lam, E., Martin, M.M., Timerman, A.P., Sabers, C., Fleischer, S., Lukas, T., Abraham, R.T., O'Keefe, S.J., O'Neill, E.A., Wiederrecht, G.J. J. Biol. Chem. (1995)
- Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes. Noguchi, N., Takasawa, S., Nata, K., Tohgo, A., Kato, I., Ikehata, F., Yonekura, H., Okamoto, H. J. Biol. Chem. (1997)
- FK506 does not affect cardiac contractility and adrenergic response in vitro. Milting, H., Janssen, P.M., Wangemann, T., Kögler, H., Domeier, E., Seidler, T., Hakim, K., Grapow, M., Zeitz, O., Prestle, J., Zerkowski, H.R. Eur. J. Pharmacol. (2001)
- In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6. George, C.H., Sorathia, R., Bertrand, B.M., Lai, F.A. Biochem. J. (2003)
- Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains. George, C.H., Jundi, H., Thomas, N.L., Scoote, M., Walters, N., Williams, A.J., Lai, F.A. Mol. Biol. Cell (2004)
- Effects of FK506-binding protein 12 and FK506 on autophosphorylation of epidermal growth factor receptor. Lopez-Ilasaca, M., Schiene, C., Küllertz, G., Tradler, T., Fischer, G., Wetzker, R. J. Biol. Chem. (1998)
- Peptidyl prolyl cis/trans-isomerases: comparative reactivities of cyclophilins, FK506-binding proteins, and parvulins with fluorinated oligopeptide and protein substrates. Golbik, R., Yu, C., Weyher-Stingl, E., Huber, R., Moroder, L., Budisa, N., Schiene-Fischer, C. Biochemistry (2005)
- Interaction of FKBP12.6 with the cardiac ryanodine receptor C-terminal domain. Zissimopoulos, S., Lai, F.A. J. Biol. Chem. (2005)
- Central domain of the human cardiac muscle ryanodine receptor does not mediate interaction with FKBP12.6. Zissimopoulos, S., Lai, F.A. Cell Biochem. Biophys. (2005)
- Ryanodine receptors, FKBP12, and heart failure. Marks, A.R. Front. Biosci. (2002)
- Catecholaminergic polymorphic ventricular tachycardia: recent mechanistic insights. Kontula, K., Laitinen, P.J., Lehtonen, A., Toivonen, L., Viitasalo, M., Swan, H. Cardiovasc. Res. (2005)
- A novel endothelin receptor antagonist CPU0213 improves diabetic cardiac insufficiency attributed to up-regulation of the expression of FKBP12.6, SERCA2a, and PLB in rats. Qi, M.Y., Xia, H.J., Dai, D.Z., Dai, Y. J. Cardiovasc. Pharmacol. (2006)
- Regulation of ryanodine receptors by FK506 binding proteins. Chelu, M.G., Danila, C.I., Gilman, C.P., Hamilton, S.L. Trends Cardiovasc. Med. (2004)
- Three-dimensional localization of divergent region 3 of the ryanodine receptor to the clamp-shaped structures adjacent to the FKBP binding sites. Zhang, J., Liu, Z., Masumiya, H., Wang, R., Jiang, D., Li, F., Wagenknecht, T., Chen, S.R. J. Biol. Chem. (2003)
- Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6. Nakazawa, T., Takasawa, S., Noguchi, N., Nata, K., Tohgo, A., Mori, M., Nakagawara, K., Akiyama, T., Ikeda, T., Yamauchi, A., Takahashi, I., Yoshikawa, T., Okamoto, H. Gene (2005)
- Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts. Arakawa, H., Nagase, H., Hayashi, N., Fujiwara, T., Ogawa, M., Shin, S., Nakamura, Y. Biochem. Biophys. Res. Commun. (1994)
- Biochemical and functional analyses of the Mip protein: influence of the N-terminal half and of peptidylprolyl isomerase activity on the virulence of Legionella pneumophila. Köhler, R., Fanghänel, J., König, B., Lüneberg, E., Frosch, M., Rahfeld, J.U., Hilgenfeld, R., Fischer, G., Hacker, J., Steinert, M. Infect. Immun. (2003)