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Gene Review: 

Madd  -  MAP-kinase activating death domain

Mus musculus

Synonyms: 9630059K23Rik, IG20, Kiaa0358, MAP kinase-activating death domain protein, Rab3 GDP/GTP exchange factor, ...
 
 
 
 
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High impact information on Madd

  • In our present study, we established that certain cancer cell lines express conspicuously higher levels of the 2 DENN isoforms in contrast to the 2 pro-apoptotic IG20 isoforms [1].

References

  1. Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle. Lim, K.M., Yeo, W.S., Chow, V.T. Int. J. Cancer (2004) [Pubmed]
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