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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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DZIP1  -  DAZ interacting zinc finger protein 1

Homo sapiens

Synonyms: DAZ-interacting protein 1/2, DZIP, DZIP2, DZIPt1, KIAA0996, ...
 
 
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Disease relevance of DZIP1

  • Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells [1].
 

High impact information on DZIP1

  • Positional cloning revealed that the igu locus encodes Dzip1, a novel intracellular protein that contains a single zinc-finger protein-protein interaction domain [2].
  • A transcript encoding a rat homologue of DZIP1 (DAZ-interacting protein) was isolated from testis RNA [3].
  • The rat genome also contained a further predicted homologue of DZIP1 displaying conserved linkage homology with mouse Dzip1 and DZIP1 [3].
  • Finally, we provide evidence indicating that DZIP may associate with DAZ and its other cofactors in an RNA-binding protein complex that functions in both ES cells and germ cells [1].
 

Biological context of DZIP1

  • Here we report the identification and characterization of the DZIP (DAZ-Interacting Protein) gene, which encodes at least three different protein isoforms that contain a C2H2 zinc-finger domain [1].

References

 
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