Gene Review:
DKK1 - dickkopf WNT signaling pathway inhibitor 1
Homo sapiens
Synonyms:
DKK-1, Dickkopf-1, Dickkopf-related protein 1, Dkk-1, SK, ...
- Mutation analysis of DKK1 and in vivo evidence of predominant p53-independent DKK1 function in gliomas. Mueller, W., Lass, U., Wellmann, S., Kunitz, F., von Deimling, A. Acta Neuropathol. (2005)
- The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly. Roessler, E., Du, Y., Glinka, A., Dutra, A., Niehrs, C., Muenke, M. Cytogenet. Cell Genet. (2000)
- The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. Tian, E., Zhan, F., Walker, R., Rasmussen, E., Ma, Y., Barlogie, B., Shaughnessy, J.D. N. Engl. J. Med. (2003)
- Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. Aguilera, O., Fraga, M.F., Ballestar, E., Paz, M.F., Herranz, M., Espada, J., García, J.M., Muñoz, A., Esteller, M., González-Sancho, J.M. Oncogene (2006)
- The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells. Aguilera, O., Peña, C., García, J.M., Larriba, M.J., Ordóñez-Morán, P., Navarro, D., Barbáchano, A., López de Silanes, I., Ballestar, E., Fraga, M.F., Esteller, M., Gamallo, C., Bonilla, F., González-Sancho, J.M., Muñoz, A. Carcinogenesis (2007)
- Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1. Scali, C., Caraci, F., Gianfriddo, M., Diodato, E., Roncarati, R., Pollio, G., Gaviraghi, G., Copani, A., Nicoletti, F., Terstappen, G.C., Caricasole, A. Neurobiol. Dis. (2006)
- Wnt-beta-catenin signaling initiates taste papilla development. Liu, F., Thirumangalathu, S., Gallant, N.M., Yang, S.H., Stoick-Cooper, C.L., Reddy, S.T., Andl, T., Taketo, M.M., Dlugosz, A.A., Moon, R.T., Barlow, L.A., Millar, S.E. Nat. Genet. (2007)
- Developmental biology. Making head or tail of Dickkopf. Nusse, R. Nature (2001)
- Inhibition of Wnt activity induces heart formation from posterior mesoderm. Marvin, M.J., Di Rocco, G., Gardiner, A., Bush, S.M., Lassar, A.B. Genes Dev. (2001)
- Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Bafico, A., Liu, G., Yaniv, A., Gazit, A., Aaronson, S.A. Nat. Cell Biol. (2001)
- FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. Chamorro, M.N., Schwartz, D.R., Vonica, A., Brivanlou, A.H., Cho, K.R., Varmus, H.E. EMBO J. (2005)
- Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53. Wang, J., Shou, J., Chen, X. Oncogene (2000)
- Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-kappaB ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma. Terpos, E., Heath, D.J., Rahemtulla, A., Zervas, K., Chantry, A., Anagnostopoulos, A., Pouli, A., Katodritou, E., Verrou, E., Vervessou, E.C., Dimopoulos, M.A., Croucher, P.I. Br. J. Haematol. (2006)
- Mesenchymal-epithelial interactions in the skin: increased expression of dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiation. Yamaguchi, Y., Itami, S., Watabe, H., Yasumoto, K., Abdel-Malek, Z.A., Kubo, T., Rouzaud, F., Tanemura, A., Yoshikawa, K., Hearing, V.J. J. Cell Biol. (2004)
- Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling. Ai, M., Holmen, S.L., Van Hul, W., Williams, B.O., Warman, M.L. Mol. Cell. Biol. (2005)
- The Wnt antagonist Dickkopf-1 and its receptors are coordinately regulated during early human adipogenesis. Christodoulides, C., Laudes, M., Cawthorn, W.P., Schinner, S., Soos, M., O'Rahilly, S., Sethi, J.K., Vidal-Puig, A. J. Cell. Sci. (2006)
- Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain. Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemuller, A.J., Caruso, A., Storto, M., Gaviraghi, G., Terstappen, G.C., Nicoletti, F. J. Neurosci. (2004)
- Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized rats. Wang, F.S., Ko, J.Y., Lin, C.L., Wu, H.L., Ke, H.J., Tai, P.J. Bone (2007)
- Dkk-1-derived synthetic peptides and lithium chloride for the control and recovery of adult stem cells from bone marrow. Gregory, C.A., Perry, A.S., Reyes, E., Conley, A., Gunn, W.G., Prockop, D.J. J. Biol. Chem. (2005)
- Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. Shou, J., Ali-Osman, F., Multani, A.S., Pathak, S., Fedi, P., Srivenugopal, K.S. Oncogene (2002)
- LRP5 mutations in osteoporosis-pseudoglioma syndrome and high-bone-mass disorders. Levasseur, R., Lacombe, D., de Vernejoul, M.C. Joint, bone, spine : revue du rhumatisme. (2005)
- The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer. González-Sancho, J.M., Aguilera, O., García, J.M., Pendás-Franco, N., Peña, C., Cal, S., García de Herreros, A., Bonilla, F., Muñoz, A. Oncogene (2005)
- Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men. Kiel, D.P., Ferrari, S.L., Cupples, L.A., Karasik, D., Manen, D., Imamovic, A., Herbert, A.G., Dupuis, J. Bone (2007)
- Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins. Winkler, D.G., Sutherland, M.S., Ojala, E., Turcott, E., Geoghegan, J.C., Shpektor, D., Skonier, J.E., Yu, C., Latham, J.A. J. Biol. Chem. (2005)
- Expression of secreted Wnt antagonists in gastrointestinal tissues: potential role in stem cell homeostasis. Byun, T., Karimi, M., Marsh, J.L., Milovanovic, T., Lin, F., Holcombe, R.F. J. Clin. Pathol. (2005)
- Growth promoting signaling by tenascin-C [corrected]. Ruiz, C., Huang, W., Hegi, M.E., Lange, K., Hamou, M.F., Fluri, E., Oakeley, E.J., Chiquet-Ehrismann, R., Orend, G. Cancer Res. (2004)
- Elevated expression of DKK1 is associated with cytoplasmic/nuclear beta-catenin accumulation and poor prognosis in hepatocellular carcinomas. Yu, B., Yang, X., Xu, Y., Yao, G., Shu, H., Lin, B., Hood, L., Wang, H., Yang, S., Gu, J., Fan, J., Qin, W. J. Hepatol. (2009)
- Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas. Yamabuki, T., Takano, A., Hayama, S., Ishikawa, N., Kato, T., Miyamoto, M., Ito, T., Ito, H., Miyagi, Y., Nakayama, H., Fujita, M., Hosokawa, M., Tsuchiya, E., Kohno, N., Kondo, S., Nakamura, Y., Daigo, Y. Cancer Res. (2007)
- Advanced molecular profiling in vivo detects novel function of dickkopf-3 in the regulation of bone formation. Aslan, H., Ravid-Amir, O., Clancy, B.M., Rezvankhah, S., Pittman, D., Pelled, G., Turgeman, G., Zilberman, Y., Gazit, Z., Hoffmann, A., Gross, G., Domany, E., Gazit, D. J. Bone Miner. Res. (2006)
- Dickkopf homologs in squamous mucosa of esophagitis patients are overexpressed compared with Barrett's patients and healthy controls. Ali, I., Rafiee, P., Hogan, W.J., Jacob, H.J., Komorowski, R.A., Haasler, G.B., Shaker, R. Am. J. Gastroenterol. (2006)
- Overexpression of human Dickkopf-1, an antagonist of wingless/WNT signaling, in human hepatoblastomas and Wilms' tumors. Wirths, O., Waha, A., Weggen, S., Schirmacher, P., Kühne, T., Goodyer, C.G., Albrecht, S., Von Schweinitz, D., Pietsch, T. Lab. Invest. (2003)