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Gene Review: 

SLC4A1AP  -  solute carrier family 4 (anion exchanger),...

Homo sapiens

Synonyms: FLJ10624, FLJ41004, HLC3, HLC-3, Human lung cancer oncogene 3 protein, ...
 
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Disease relevance of SLC4A1AP

 

High impact information on SLC4A1AP

  • Kanadaptin is widely expressed in epithelial (kidney, lung, and liver) and non-epithelial cells (brain and skeletal and cardiac muscle) [2].
  • That these effects were specific was implied by the fact that a number of other coexpressed karyophilic GFP-fusion proteins, such as the nucleoporin NUP98 and kanadaptin, did not coaggregate with FLAG-lamin A N195K or R386K [3].
  • Trafficking of kAE1 from its site of synthesis in the endoplasmic reticulum to the plasma membrane was unaffected by co-expression of human kanadaptin [1].
  • Kanadaptin was co-localized with kAE1 in intracellular membranes but not at the plasma membrane in alpha-intercalated cells of rabbit kidney [1].
  • The role of the different NLSs is examined in transfection studies using plasmids encoding full-length kanadaptin with or without green fluorescent protein (GFP) as a fusion tag, as well as truncation derivatives thereof [4].
 

Biological context of SLC4A1AP

 

Anatomical context of SLC4A1AP

 

Analytical, diagnostic and therapeutic context of SLC4A1AP

References

  1. Human kanadaptin and kidney anion exchanger 1 (kAE1) do not interact in transfected HEK 293 cells. Kittanakom, S., Keskanokwong, T., Akkarapatumwong, V., Yenchitsomanus, P.T., Reithmeier, R.A. Mol. Membr. Biol. (2004)
  2. Kanadaptin is a protein that interacts with the kidney but not the erythroid form of band 3. Chen, J., Vijayakumar, S., Li, X., Al-Awqati, Q. J. Biol. Chem. (1998)
  3. Laminopathy-inducing lamin A mutants can induce redistribution of lamin binding proteins into nuclear aggregates. Hübner, S., Eam, J.E., Hübner, A., Jans, D.A. Exp. Cell Res. (2006)
  4. Signal- and importin-dependent nuclear targeting of the kidney anion exchanger 1-binding protein kanadaptin. Hübner, S., Jans, D.A., Xiao, C.Y., John, A.P., Drenckhahn, D. Biochem. J. (2002)
  5. Mitochondrial and nuclear localization of kanadaptin. Hübner, S., Bahr, C., Gössmann, H., Efthymiadis, A., Drenckhahn, D. Eur. J. Cell Biol. (2003)
 

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