Gene Review:
FOXC1 - forkhead box C1
Homo sapiens
Synonyms:
ARA, FKHL7, FREAC-3, FREAC3, Forkhead box protein C1, ...
- Identification of FOXC1 as a TGF-beta1 responsive gene and its involvement in negative regulation of cell growth. Zhou, Y., Kato, H., Asanoma, K., Kondo, H., Arima, T., Kato, K., Matsuda, T., Wake, N. Genomics (2002)
- FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner. Berry, F.B., O'Neill, M.A., Coca-Prados, M., Walter, M.A. Mol. Cell. Biol. (2005)
- The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development. Seo, S., Fujita, H., Nakano, A., Kang, M., Duarte, A., Kume, T. Dev. Biol. (2006)
- ARA, a novel ABC transporter, is located at 16p13.1, is deleted in inv(16) leukemias, and is shown to be expressed in primitive hematopoietic precursors. Kuss, B.J., O'Neill, G.M., Eyre, H., Doggett, N.A., Callen, D.F., Davey, R.A. Genomics (1998)
- Adenine arabinoside 5'-monophosphate in patients with chronic hepatitis B: comparison of the efficacy in patients with high and low viral replication. Marcellin, P., Pouteau, M., Loriot, M.A., Boyer, N., Degos, F., Calès, P., Bettan, L., Bacq, Y., Coppére, H., Grange, J.D. Gut (1995)
- The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25. Nishimura, D.Y., Swiderski, R.E., Alward, W.L., Searby, C.C., Patil, S.R., Bennet, S.R., Kanis, A.B., Gastier, J.M., Stone, E.M., Sheffield, V.C. Nat. Genet. (1998)
- Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1. Saleem, R.A., Banerjee-Basu, S., Berry, F.B., Baxevanis, A.D., Walter, M.A. Am. J. Hum. Genet. (2001)
- A spectrum of FOXC1 mutations suggests gene dosage as a mechanism for developmental defects of the anterior chamber of the eye. Nishimura, D.Y., Searby, C.C., Alward, W.L., Walton, D., Craig, J.E., Mackey, D.A., Kawase, K., Kanis, A.B., Patil, S.R., Stone, E.M., Sheffield, V.C. Am. J. Hum. Genet. (2001)
- Angiotensin system inhibitors in a general surgical population. Comfere, T., Sprung, J., Kumar, M.M., Draper, M., Wilson, D.P., Williams, B.A., Danielson, D.R., Liedl, L., Warner, D.O. Anesth. Analg. (2005)
- The hemodynamic effects of anesthetic induction in vascular surgical patients chronically treated with angiotensin II receptor antagonists. Brabant, S.M., Bertrand, M., Eyraud, D., Darmon, P.L., Coriat, P. Anesth. Analg. (1999)
- Etoposide in combination with intermediate dose cytosine arabinoside (ID ARA C) given with the intention of further myeloablative therapy for the treatment of refractory or recurrent hematological malignancy. Whelan, J.S., Davis, C.L., Rohatiner, A.Z., Leahy, M., MacCallum, P.K., Gupta, R.K., Matthews, J., Norton, A.J., Amess, J.A., Lister, T.A. Hematological oncology. (1992)
- Cardiologic abnormalities in patients with long-term lupus nephritis. Moroni, G., La Marchesina, U., Banfi, G., Nador, F., Vigano, E., Marconi, M., Lotto, A., Ponticelli, C. Clin. Nephrol. (1995)
- Structural and functional analyses of disease-causing missense mutations in the forkhead domain of FOXC1. Saleem, R.A., Banerjee-Basu, S., Berry, F.B., Baxevanis, A.D., Walter, M.A. Hum. Mol. Genet. (2003)
- Novel anterior segment phenotypes resulting from forkhead gene alterations: evidence for cross-species conservation of function. Lehmann, O.J., Tuft, S., Brice, G., Smith, R., Blixt, A., Bell, R., Johansson, B., Jordan, T., Hitchings, R.A., Khaw, P.T., John, S.W., Carlsson, P., Bhattacharya, S.S. Invest. Ophthalmol. Vis. Sci. (2003)
- A family with Axenfeld-Rieger syndrome and Peters Anomaly caused by a point mutation (Phe112Ser) in the FOXC1 gene. Honkanen, R.A., Nishimura, D.Y., Swiderski, R.E., Bennett, S.R., Hong, S., Kwon, Y.H., Stone, E.M., Sheffield, V.C., Alward, W.L. Am. J. Ophthalmol. (2003)
- FOXC1 transcriptional regulation is mediated by N- and C-terminal activation domains and contains a phosphorylated transcriptional inhibitory domain. Berry, F.B., Saleem, R.A., Walter, M.A. J. Biol. Chem. (2002)
- Transcriptional genomics associates FOX transcription factors with human heart failure. Hannenhalli, S., Putt, M.E., Gilmore, J.M., Wang, J., Parmacek, M.S., Epstein, J.A., Morrisey, E.E., Margulies, K.B., Cappola, T.P. Circulation (2006)
- Optimal procedure for extracting RNA from human ocular tissues and expression profiling of the congenital glaucoma gene FOXC1 using quantitative RT-PCR. Wang, W.H., McNatt, L.G., Shepard, A.R., Jacobson, N., Nishimura, D.Y., Stone, E.M., Sheffield, V.C., Clark, A.F. Mol. Vis. (2001)
- Screening for mutations in BMP4 and FOXC1 genes in congenital anomalies of the kidney and urinary tract in humans. Nakano, T., Niimura, F., Hohenfellner, K., Miyakita, E., Ichikawa, I. Tokai J. Exp. Clin. Med. (2003)
- Regulation of FOXC1 stability and transcriptional activity by an epidermal growth factor-activated mitogen-activated protein kinase signaling cascade. Berry, F.B., Mirzayans, F., Walter, M.A. J. Biol. Chem. (2006)
- Identification of target genes regulated by FOXC1 using nickel agarose-based chromatin enrichment. Tamimi, Y., Lines, M., Coca-Prados, M., Walter, M.A. Invest. Ophthalmol. Vis. Sci. (2004)
- Missing endomysial and reticulin binding of coeliac antibodies in transglutaminase 2 knockout tissues. Korponay-Szabó, I.R., Laurila, K., Szondy, Z., Halttunen, T., Szalai, Z., Dahlbom, I., Rantala, I., Kovács, J.B., Fésüs, L., Mäki, M. Gut (2003)
- Differential effect of ARA-AMP on serum DNA polymerase activity and serum HBV-DNA in chronic hepatitis B virus infection. A possible reason for lack of efficacy. Alexander, G.J., Fagan, E.A., Rolando, N., Guarner, P., Callender, M.E., Eddleston, A.L., Williams, R. J. Hepatol. (1986)
- A novel syndrome of congenital lid and punctal anomalies, corneal and chorioretinal dystrophy. Lee, T.K., Hébert, M., MacDonald, I.M. Ophthalmic Genet. (2003)
- Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis. Berry, F.B., Lines, M.A., Oas, J.M., Footz, T., Underhill, D.A., Gage, P.J., Walter, M.A. Hum. Mol. Genet. (2006)
- FGF19 is a target for FOXC1 regulation in ciliary body-derived cells. Tamimi, Y., Skarie, J.M., Footz, T., Berry, F.B., Link, B.A., Walter, M.A. Hum. Mol. Genet. (2006)
- Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development. Smith, R.S., Zabaleta, A., Kume, T., Savinova, O.V., Kidson, S.H., Martin, J.E., Nishimura, D.Y., Alward, W.L., Hogan, B.L., John, S.W. Hum. Mol. Genet. (2000)
- Reduced human and murine corneal thickness in an axenfeld-rieger syndrome subtype. Asai-Coakwell, M., Backhouse, C., Casey, R.J., Gage, P.J., Lehmann, O.J. Invest. Ophthalmol. Vis. Sci. (2006)
- Genetic basis of glaucoma. WuDunn, D. Current opinion in ophthalmology. (2002)
- Subtelomeric deletions of chromosome 6p: molecular and cytogenetic characterization of three new cases with phenotypic overlap with Ritscher-Schinzel (3C) syndrome. Descipio, C., Schneider, L., Young, T.L., Wasserman, N., Yaeger, D., Lu, F., Wheeler, P.G., Williams, M.S., Bason, L., Jukofsky, L., Menon, A., Geschwindt, R., Chudley, A.E., Saraiva, J., Schinzel, A.A., Guichet, A., Dobyns, W.E., Toutain, A., Spinner, N.B., Krantz, I.D. Am. J. Med. Genet. A (2005)
- Identification and analysis of a novel mutation in the FOXC1 forkhead domain. Saleem, R.A., Murphy, T.C., Liebmann, J.M., Walter, M.A. Invest. Ophthalmol. Vis. Sci. (2003)
- Randomised controlled trial of adenine arabinoside 5'-monophosphate (ARA-AMP) in chronic hepatitis B virus infection. Weller, I.V., Lok, A.S., Mindel, A., Karayiannis, P., Galpin, S., Monjardino, J., Sherlock, S., Thomas, H.C. Gut (1985)