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Gene Review

FOXD4  -  forkhead box D4

Homo sapiens

Synonyms: FKHL9, FOXD4A, FOXD4a, FREAC-5, FREAC5, ...
 
 
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Disease relevance of FOXD4

  • The genomic clones coding for two new winged helix proteins, FOXD4a and FOXD4b were isolated by high-stringency hybridization of a human phage library [1].
 

Psychiatry related information on FOXD4

 

High impact information on FOXD4

  • These paralogous regions share large continuous homologies and contain three genes: RABL2B, forkhead box D4, and COBW-like [3].
  • Based upon these studies, our results suggest that FOXD4a and FOXD4b may play a role in leukemogenesis [1].
  • FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines [1].
  • This mutation disrupts an extremely highly conserved tryptophan residue in the forkhead domain of FOXD4, possibly resulting in reduced DNA binding capacity and altered transcriptional activity [2].
 

Biological context of FOXD4

 

Associations of FOXD4 with chemical compounds

  • FOXD4a and FOXD4b are encoded by a 1319 and 1250 bp single exon coding for a winged helix DNA binding domain, an amino-terminal acidic region and a carboxy-terminal proline- and alanine-rich region which correspond to putative transcriptional regulatory motifs [1].

References

  1. FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines. Freyaldenhoven, B.S., Fried, C., Wielckens, K. Gene (2002) [Pubmed]
  2. A W148R mutation in the human FOXD4 gene segregating with dilated cardiomyopathy, obsessive-compulsive disorder, and suicidality. Minoretti, P., Arra, M., Emanuele, E., Olivieri, V., Aldeghi, A., Politi, P., Martinelli, V., Pesenti, S., Falcone, C. Int. J. Mol. Med. (2007) [Pubmed]
  3. The evolutionary origin of human subtelomeric homologies--or where the ends begin. Martin, C.L., Wong, A., Gross, A., Chung, J., Fantes, J.A., Ledbetter, D.H. Am. J. Hum. Genet. (2002) [Pubmed]
 
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