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FAIM2  -  Fas apoptotic inhibitory molecule 2

Homo sapiens

Synonyms: KIAA0950, LFG, LFG2, LIFEGUARD, NGP35, ...
 
 
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High impact information on FAIM2

  • Furthermore LFG does not inhibit binding of FADD to Fas [1].
  • LFG is widely distributed, but remarkably is highly expressed in the hippocampus [1].
  • LFG: an anti-apoptotic gene that provides protection from Fas-mediated cell death [1].
  • The structure of Lifeguard resembles the antiapoptotic protein Bax Inhibitor-1 (BI-1) [2].
  • Our results indicate that LFG belongs to a new cytoprotective family with evolutionarily conserved functions in the prevention of programmed cell death [2].
 

Biological context of FAIM2

  • Because carbon dioxide (CO(2)) is the main compound in the extracted off-gas (instead of methane (CH(4)), which dominated under anaerobic landfill conditions), the negative impact of diffuse LFG emissions towards an increased global warming effect may be significantly lowered [3].
 

Anatomical context of FAIM2

  • Together with the medial LFG (medLFG), the latLFG resides outside the array of spheroidal ordinary glomeruli, near the entrance of the antennal (olfactory) nerve [4].
 

Associations of FAIM2 with chemical compounds

  • Ten km performance times were not different (WP = 41.87, HFG = 41.66, LFG = 41.79, GLU = 41.65, BAN = 41.53, and SUG = 41.75 min) [5].
 

Analytical, diagnostic and therapeutic context of FAIM2

References

  1. LFG: an anti-apoptotic gene that provides protection from Fas-mediated cell death. Somia, N.V., Schmitt, M.J., Vetter, D.E., Van Antwerp, D., Heinemann, S.F., Verma, I.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Sequence analysis shows that Lifeguard belongs to a new evolutionarily conserved cytoprotective family. Reimers, K., Choi, C.Y., Mau-Thek, E., Vogt, P.M. Int. J. Mol. Med. (2006) [Pubmed]
  3. Fundamental processes and implications during in situ aeration of old landfills. Ritzkowski, M., Heyer, K.U., Stegmann, R. Waste management (New York, N.Y.) (2006) [Pubmed]
  4. Response characteristics of an identified, sexually dimorphic olfactory glomerulus. King, J.R., Christensen, T.A., Hildebrand, J.G. J. Neurosci. (2000) [Pubmed]
  5. Pre-exercise carbohydrate and fluid ingestion: influence of glycemic response on 10-km treadmill running performance in the heat. Mitchell, J.B., Braun, W.A., Pizza, F.X., Forrest, M. The Journal of sports medicine and physical fitness. (2000) [Pubmed]
 
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