Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Wnk1 - WNK lysine deficient protein kinase 1

Mus musculus

Synonyms: 6430573H23Rik, EG406236, Hsn2, Prkwnk1, Protein kinase lysine-deficient 1, ...

Zambrowicz, B.P. et al.

Zambrowicz, Abuin, Ramirez-Solis, Richter, Piggott, BeltrandelRio, Buxton, Edwards, Finch, Friddle, Gupta, Hansen, Hu, Huang, Jaing, Key, Kipp, Kohlhauff, Ma, Markesich, Payne, Potter, Qian, Shaw, Schrick, Shi, Sparks, Van Sligtenhorst, Vogel, Walke, Xu, Zhu, Person, Sands,

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High impact information on Wnk1

Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention [1].
Mice homozygous for the Wnk1 mutation died during embryonic development before day 13 of gestation [1].
These results demonstrate that Wnk1 is a regulator of blood pressure critical for development and illustrate the utility of a functional screen driven by a sequence-based mutagenesis approach [1].

References

Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz, B.P., Abuin, A., Ramirez-Solis, R., Richter, L.J., Piggott, J., BeltrandelRio, H., Buxton, E.C., Edwards, J., Finch, R.A., Friddle, C.J., Gupta, A., Hansen, G., Hu, Y., Huang, W., Jaing, C., Key, B.W., Kipp, P., Kohlhauff, B., Ma, Z.Q., Markesich, D., Payne, R., Potter, D.G., Qian, N., Shaw, J., Schrick, J., Shi, Z.Z., Sparks, M.J., Van Sligtenhorst, I., Vogel, P., Walke, W., Xu, N., Zhu, Q., Person, C., Sands, A.T. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]

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