Gene Review:
PLCB1 - phospholipase C, beta 1 (phosphoinositide...
Homo sapiens
Synonyms:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1, EIEE12, KIAA0581, PI-PLC, PLC-154, ...
- Molecular cloning, expression and regulatory activity of G alpha 11- and beta gamma-subunit-stimulated phospholipase C-beta from avian erythrocytes. Waldo, G.L., Paterson, A., Boyer, J.L., Nicholas, R.A., Harden, T.K. Biochem. J. (1996)
- Identification and characterization of G protein-regulated phospholipase C in human myocardium. Schnabel, P., Gäs, H., Nohr, T., Camps, M., Böhm, M. J. Mol. Cell. Cardiol. (1996)
- G proteins in signal transduction: the regulation of phospholipase C. Sternweis, P.C., Smrcka, A.V. Ciba Found. Symp. (1993)
- Small cell lung carcinoma exhibits greater phospholipase C-beta1 expression and edelfosine resistance compared with non-small cell lung carcinoma. Strassheim, D., Shafer, S.H., Phelps, S.H., Williams, C.L. Cancer Res. (2000)
- Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2. Park, D., Jhon, D.Y., Kriz, R., Knopf, J., Rhee, S.G. J. Biol. Chem. (1992)
- Metabotropic glutamate receptor/phospholipase C pathway: a vulnerable target to Creutzfeldt-Jakob disease in the cerebral cortex. Rodríguez, A., Freixes, M., Dalfó, E., Martín, M., Puig, B., Ferrer, I. Neuroscience (2005)
- Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator. Berstein, G., Blank, J.L., Jhon, D.Y., Exton, J.H., Rhee, S.G., Ross, E.M. Cell (1992)
- Determination of the primary structure of PLC-154 demonstrates diversity of phosphoinositide-specific phospholipase C activities. Katan, M., Kriz, R.W., Totty, N., Philp, R., Meldrum, E., Aldape, R.A., Knopf, J.L., Parker, P.J. Cell (1988)
- Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. Mahon, M.J., Donowitz, M., Yun, C.C., Segre, G.V. Nature (2002)
- Expression of phospholipases gamma 1, beta 1, and delta 1 in primary human colon carcinomas and colon carcinoma cell lines. Nomoto, K., Tomita, N., Miyake, M., Xhu, D.B., LoGerfo, P.R., Weinstein, I.B. Mol. Carcinog. (1995)
- Tissue- and cell type-specific expression of mRNAs for four types of inositol phospholipid-specific phospholipase C. Homma, Y., Takenawa, T., Emori, Y., Sorimachi, H., Suzuki, K. Biochem. Biophys. Res. Commun. (1989)
- Abnormal metabotropic glutamate receptor expression and signaling in the cerebral cortex in diffuse Lewy body disease is associated with irregular alpha-synuclein/phospholipase C (PLCbeta1) interactions. Dalfó, E., Albasanz, J.L., Martin, M., Ferrer, I. Brain Pathol. (2004)
- Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1. McLaughlin, J.N., Shen, L., Holinstat, M., Brooks, J.D., Dibenedetto, E., Hamm, H.E. J. Biol. Chem. (2005)
- NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation. Oh, Y.S., Jo, N.W., Choi, J.W., Kim, H.S., Seo, S.W., Kang, K.O., Hwang, J.I., Heo, K., Kim, S.H., Kim, Y.H., Kim, I.H., Kim, J.H., Banno, Y., Ryu, S.H., Suh, P.G. Mol. Cell. Biol. (2004)
- Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2. Hwang, J.I., Heo, K., Shin, K.J., Kim, E., Yun, C., Ryu, S.H., Shin, H.S., Suh, P.G. J. Biol. Chem. (2000)
- Phospholipase C-beta3 and -beta1 form homodimers, but not heterodimers, through catalytic and carboxyl-terminal domains. Zhang, Y., Vogel, W.K., McCullar, J.S., Greenwood, J.A., Filtz, T.M. Mol. Pharmacol. (2006)
- Impaired signal transduction in neonatal platelets. Israels, S.J., Cheang, T., Roberston, C., McMillan-Ward, E.M., McNicol, A. Pediatr. Res. (1999)
- Effects of gelsolin on human platelet cytosolic phosphoinositide-phospholipase C isozymes. Banno, Y., Nakashima, T., Kumada, T., Ebisawa, K., Nonomura, Y., Nozawa, Y. J. Biol. Chem. (1992)
- Reconstitution of thromboxane A2 receptor-stimulated phosphoinositide hydrolysis in isolated platelet membranes: involvement of phosphoinositide-specific phospholipase C-beta and GTP-binding protein Gq. Baldassare, J.J., Tarver, A.P., Henderson, P.A., Mackin, W.M., Sahagan, B., Fisher, G.J. Biochem. J. (1993)
- Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50). Rochdi, M.D., Watier, V., La Madeleine, C., Nakata, H., Kozasa, T., Parent, J.L. J. Biol. Chem. (2002)
- The Pleckstrin homology domains of phospholipases C-beta and -delta confer activation through a common site. Guo, Y., Philip, F., Scarlata, S. J. Biol. Chem. (2003)
- Role of the gamma subunit prenyl moiety in G protein beta gamma complex interaction with phospholipase Cbeta. Fogg, V.C., Azpiazu, I., Linder, M.E., Smrcka, A., Scarlata, S., Gautam, N. J. Biol. Chem. (2001)
- Proteolytic modification of membrane-associated phospholipase C-beta by mu-calpain enhances its activation by G-protein beta gamma subunits in human platelets. Banno, Y., Asano, T., Nozawa, Y. FEBS Lett. (1994)
- RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha. Hepler, J.R., Berman, D.M., Gilman, A.G., Kozasa, T. Proc. Natl. Acad. Sci. U.S.A. (1997)
- The pleckstrin homology domain of phospholipase C-beta2 as an effector site for Rac. Snyder, J.T., Singer, A.U., Wing, M.R., Harden, T.K., Sondek, J. J. Biol. Chem. (2003)
- CD45 modulates T cell receptor/CD3-induced activation of human thymocytes via regulation of tyrosine phosphorylation. Turka, L.A., Kanner, S.B., Schieven, G.L., Thompson, C.B., Ledbetter, J.A. Eur. J. Immunol. (1992)
- Galphaq-coupled receptor internalization specifically induced by Galphaq signaling. Regulation by EBP50. Rochdi, M.D., Parent, J.L. J. Biol. Chem. (2003)
- Decrease in thromboxane A2 receptor expression by differentiation with dibutyryl cyclic AMP in 1321N1 human astrocytoma cells. Honma, S., Nakahata, N., Kobayashi, H., Ikeda, S., Takeda, N., Ohizumi, Y. Prostaglandins Other Lipid Mediat. (1999)
- Molecular characterization of the human PLC beta1 gene. Peruzzi, D., Aluigi, M., Manzoli, L., Billi, A.M., Di Giorgio, F.P., Morleo, M., Martelli, A.M., Cocco, L. Biochim. Biophys. Acta (2002)
- Inhibition of serum- and ras-stimulated DNA synthesis by antibodies to phospholipase C. Smith, M.R., Liu, Y.L., Kim, H., Rhee, S.G., Kung, H.F. Science (1990)
- Characterization of the phosphatidylinositol-specific phospholipase C isozymes present in the bovine parathyroid and in human kidney HEK293 cells stably transfected with the human parathyroid Ca2+-sensing receptor. Darè, E., Kifor, O., Brown, E.M., Weber, G. J. Mol. Endocrinol. (1998)