The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

SATB2  -  SATB homeobox 2

Homo sapiens

Synonyms: DNA-binding protein SATB2, FLJ21474, KIAA1034, Special AT-rich sequence-binding protein 2
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of SATB2

 

High impact information on SATB2

  • Molecular analysis revealed that SATB2 directly interacts with and enhances the activity of both Runx2 and ATF4, transcription factors that regulate osteoblast differentiation [2].
  • In addition, SATB2 was found to repress the expression of several Hox genes including Hoxa2, an inhibitor of bone formation and regulator of branchial arch patterning [2].
  • In this issue of Cell, Grosschedl and colleagues (Dobreva et al., 2006) report that the nuclear matrix protein Satb2 represses Hoxa2 expression and acts with other regulatory proteins to promote osteoblast differentiation [3].
  • SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression [4].
  • Here we characterize a novel cell type-specific MAR-binding protein, SATB2, which binds to the MARs of the endogenous immunoglobulin micro locus in pre-B cells and enhances gene expression [4].
 

Biological context of SATB2

  • SATB2-encoding transcripts are assembled from 11 exons that span 191 kb of genomic DNA [1].
  • The breakpoint in the other translocation is located 130 kb 3' to the SATB2 polyadenylation signal, within a conserved region of non-coding DNA [1].
  • Isolation and Characterization of SATB2, a Novel AT-rich DNA Binding Protein Expressed in Development- and Cell-Specific Manner in the Rat Brain [5].
  • Because jaw development is Satb2-dosage sensitive, the regulators of Satb2 expression and posttranslational modification become of critical importance both ontogenetically and evolutionarily, especially since such regulators plausibly play undetected roles in jaw and palate development and in the etiology of craniofacial malformations [6].
 

Anatomical context of SATB2

  • SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation [2].
  • Using DNA-affinity purification followed by mass spectrometry we identified and isolated a related protein, SATB2 from the developing rat cerebral cortex [5].
  • Using RT-PCR, Western analysis and immunohistochemistry we demonstrate that SATB2 expression is restricted to a subset of postmitotic, differentiating neurons in the rat neocortex at ages E16 and P4 [5].
 

Other interactions of SATB2

  • SATB2 shows homology to SATB1 and the rat protein is practically identical to the mouse and human SATB2 [5].
 

Analytical, diagnostic and therapeutic context of SATB2

References

  1. Identification of SATB2 as the cleft palate gene on 2q32-q33. FitzPatrick, D.R., Carr, I.M., McLaren, L., Leek, J.P., Wightman, P., Williamson, K., Gautier, P., McGill, N., Hayward, C., Firth, H., Markham, A.F., Fantes, J.A., Bonthron, D.T. Hum. Mol. Genet. (2003) [Pubmed]
  2. SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Dobreva, G., Chahrour, M., Dautzenberg, M., Chirivella, L., Kanzler, B., Fariñas, I., Karsenty, G., Grosschedl, R. Cell (2006) [Pubmed]
  3. Bone formation: The nuclear matrix reloaded. Ellies, D.L., Krumlauf, R. Cell (2006) [Pubmed]
  4. SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression. Dobreva, G., Dambacher, J., Grosschedl, R. Genes Dev. (2003) [Pubmed]
  5. Isolation and Characterization of SATB2, a Novel AT-rich DNA Binding Protein Expressed in Development- and Cell-Specific Manner in the Rat Brain. Szemes, M., Gyorgy, A., Paweletz, C., Dobi, A., Agoston, D.V. Neurochem. Res. (2006) [Pubmed]
  6. Satb2 Haploinsufficiency Phenocopies 2q32-q33 Deletions, whereas Loss Suggests a Fundamental Role in the Coordination of Jaw Development. Britanova, O., Depew, M.J., Schwark, M., Thomas, B.L., Miletich, I., Sharpe, P., Tarabykin, V. Am. J. Hum. Genet. (2006) [Pubmed]
 
WikiGenes - Universities