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Gene Review

CLASP1  -  cytoplasmic linker associated protein 1

Homo sapiens

Synonyms: CLIP-associating protein 1, Cytoplasmic linker-associated protein 1, KIAA0622, MAST1, Multiple asters homolog 1, ...
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Disease relevance of CLASP1


High impact information on CLASP1

  • Microinjection of CLASP1-specific antibodies suppresses microtubule dynamics at kinetochores and throughout the spindle, resulting in the formation of monopolar asters with chromosomes buried in the interior [6].
  • Our data suggest that CLASP1 is required at kinetochores for attached microtubules to exhibit normal dynamic behavior [6].
  • RESULTS: Mast cell density was significantly greater in the mucosa with gastritis, with or without H. pylori infection, than in the mucosa of noninfected normal subjects [1].
  • BACKGROUND: Mast-cell regulation of intestinal ion transport, previously shown in animals and cultured cells, was examined in surgically resected human bowel in this study [7].
  • The defects observed in the mutant alleles and the intracellular localization of the protein suggest that Mast plays an essential role in centrosome separation and organization of the bipolar mitotic spindle [8].

Chemical compound and disease context of CLASP1


Biological context of CLASP1


Anatomical context of CLASP1


Associations of CLASP1 with chemical compounds

  • CONCLUSION: Mast cell-derived mediators prostaglandin D(2) and leukotriene D(4) and mast cell-related neutral proteases carboxypeptidase A and tryptase increase the proliferation and type I collagen production of human dermal fibroblasts in various manners [13].
  • To investigate the roles of protein phosphatases 1 and 2A in the development of pollen tubes of Picea wilsonii Mast., pollen grains were cultured in standard medium in the presence and absence of the protein phosphatase inhibitors okadaic acid and calyculin A [21].
  • 1. Mast cell mediators PGD2 and LTD4 may play important roles in asthma pathogenesis [22].
  • The Mercia kit provided most user satisfaction; the Mast and Abbott assays were most difficult to use [23].
  • METHODS: Five antibody capture assays supplied by Abbott, Mercia, Northumbria, Organon and Sorin, and two indirect ELISA assays from Biostat and Mast, were assessed [23].

Other interactions of CLASP1


Analytical, diagnostic and therapeutic context of CLASP1

  • RESULTS: Mast cell density in the control group was not significantly different from that in CLDP+ group or from that in the CLDP- group [24].
  • METHODS: Mast cell tryptase was measured by immunoassay in 68 post-mortem sera remaining from a previous study which reported elevated venom-specific IgE antibodies in 22 (23%) of 94 victims of sudden unexpected death [25].
  • The osteosynthesis technique introduced by Mast and Ganz of indirect reduction by distractor without dissection of the fragments and the medial cortex allowed the complication rate to be reduced to 0% [26].
  • In this study, seven commercial EIAs (Biotrin, DAKO, Viramed, Viratech, R-Biopharm, Mast) were compared with an in-house EIA (MvP-EIA) using native viral B19 particles and the reference IgM radioimmunoassay (MACRIA) [27].
  • METHOD OF STUDY: Mast cells were identified by immunohistochemistry using monoclonal antibody against mast cell tryptase on formalin-fixed, paraffin-embedded sections [28].


  1. Mast cell involvement in gastritis with or without Helicobacter pylori infection. Nakajima, S., Krishnan, B., Ota, H., Segura, A.M., Hattori, T., Graham, D.Y., Genta, R.M. Gastroenterology (1997) [Pubmed]
  2. Pseudomonas aeruginosa-Induced Human Mast Cell Apoptosis Is Associated with Up-Regulation of Endogenous Bcl-xS and Down-Regulation of Bcl-xL. Jenkins, C.E., Swiatoniowski, A., Power, M.R., Lin, T.J. J. Immunol. (2006) [Pubmed]
  3. Levels of mast-cell growth factors in plasma and in suction skin blister fluid in adults with mastocytosis: correlation with dermal mast-cell numbers and mast-cell tryptase. Brockow, K., Akin, C., Huber, M., Scott, L.M., Schwartz, L.B., Metcalfe, D.D. J. Allergy Clin. Immunol. (2002) [Pubmed]
  4. Functional KCa3.1 K+ channels are required for human lung mast cell migration. Cruse, G., Duffy, S.M., Brightling, C.E., Bradding, P. Thorax (2006) [Pubmed]
  5. Hematologic Aspects of Mastocytosis: II: Management of Hematologic Disorders in Association with Systemic Mast Cell Disease. Parker, R.I. J. Invest. Dermatol. (1991) [Pubmed]
  6. Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics. Maiato, H., Fairley, E.A., Rieder, C.L., Swedlow, J.R., Sunkel, C.E., Earnshaw, W.C. Cell (2003) [Pubmed]
  7. Anti-immunoglobulin E-stimulated ion transport in human large and small intestine. Crowe, S.E., Perdue, M.H. Gastroenterology (1993) [Pubmed]
  8. Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization. Lemos, C.L., Sampaio, P., Maiato, H., Costa, M., Omel'yanchuk, L.V., Liberal, V., Sunkel, C.E. EMBO J. (2000) [Pubmed]
  9. Environmental pathology. Mast cell and eosinophil infiltration in intestinal mucosa of Lewis rats treated with L-tryptophan implicated in human eosinophilia myalgia syndrome. DeSchryver-Kecskemeti, K., Gramlich, T.L., Crofford, L.J., Rader, J.I., Page, S.W., Needham, L.L., Hill, R.H., Sternberg, E.M. Mod. Pathol. (1991) [Pubmed]
  10. Detection of antibodies to human immunodeficiency virus type 1 in whole blood and saliva by using a passive hemagglutination test. Vasudevachari, M.B., Uffelman, K., Pierce, P.F., Lane, H.C., Salzman, N.P. J. Clin. Microbiol. (1989) [Pubmed]
  11. Mast cells in bronchiolitis obliterans organizing pneumonia. Mast cell hyperplasia and evidence for extracellular release of tryptase. Pesci, A., Majori, M., Piccoli, M.L., Casalini, A., Curti, A., Franchini, D., Gabrielli, M. Chest (1996) [Pubmed]
  12. Application of a physiologically based pharmacokinetic model for reference dose and reference concentration estimation for acetone. Gentry, P.R., Covington, T.R., Clewell, H.J., Anderson, M.E. J. Toxicol. Environ. Health Part A (2003) [Pubmed]
  13. Effect of mast cell-derived mediators and mast cell-related neutral proteases on human dermal fibroblast proliferation and type I collagen production. Abe, M., Kurosawa, M., Ishikawa, O., Miyachi, Y. J. Allergy Clin. Immunol. (2000) [Pubmed]
  14. Mast cell migration to Th2 stimulated airway smooth muscle from asthmatics. Sutcliffe, A., Kaur, D., Page, S., Woodman, L., Armour, C.L., Baraket, M., Bradding, P., Hughes, J.M., Brightling, C.E. Thorax (2006) [Pubmed]
  15. cDNA sequence of two sheep mast cell tryptases and the differential expression of tryptase and sheep mast cell proteinase-1 in lung, dermis and gastrointestinal tract. Pemberton, A.D., McAleese, S.M., Huntley, J.F., Collie, D.D., Scudamore, C.L., McEuen, A.R., Walls, A.F., Miller, H.R. Clin. Exp. Allergy (2000) [Pubmed]
  16. Microtubule bundle formation and cell death induced by the human CLASP/Orbit N-terminal fragment. Aonuma, M., Miyamoto, M., Inoue, Y.H., Tamai, K., Sakai, H., Kamasawa, N., Matsukage, A. Cell Struct. Funct. (2005) [Pubmed]
  17. Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment. Mimori-Kiyosue, Y., Grigoriev, I., Sasaki, H., Matsui, C., Akhmanova, A., Tsukita, S., Vorobjev, I. Genes Cells (2006) [Pubmed]
  18. Airway Smooth Muscle and Mast Cell-derived CC Chemokine Ligand 19 Mediate Airway Smooth Muscle Migration in Asthma. Kaur, D., Saunders, R., Berger, P., Siddiqui, S., Woodman, L., Wardlaw, A., Bradding, P., Brightling, C.E. Am. J. Respir. Crit. Care Med. (2006) [Pubmed]
  19. Characterization of mast-cell tryptase-expressing peripheral blood cells as basophils. Foster, B., Schwartz, L.B., Devouassoux, G., Metcalfe, D.D., Prussin, C. J. Allergy Clin. Immunol. (2002) [Pubmed]
  20. Activation of fibroblasts in collagen lattices by mast cell extract: a model of fibrosis. Berton, A., Levi-Schaffer, F., Emonard, H., Garbuzenko, E., Gillery, P., Maquart, F.X. Clin. Exp. Allergy (2000) [Pubmed]
  21. Protein phosphatases 1 and 2A and the regulation of calcium uptake and pollen tube development in Picea wilsonii. Kong, L., Wang, M., Wang, Q., Wang, X., Lin, J. Tree Physiol. (2006) [Pubmed]
  22. The reproducibility and effect on non-specific airway responsiveness of inhaled prostaglandin D2 and leukotriene D4 in asthmatic subjects. Wood-Baker, R., Town, G.I., Benning, B., Holgate, S.T. British journal of clinical pharmacology. (1995) [Pubmed]
  23. Comparison of relative uses of commercial assays for Toxoplasma gondii IgM antibodies. Ashburn, D., Evans, R., Skinner, L.J., Chatterton, J.M., Joss, A.W., Ho-Yen, D.O. J. Clin. Pathol. (1992) [Pubmed]
  24. Cholestatic pruritus - the role of cutaneous mast cells and nerves. O'Keeffe, C., Baird, A.W., Nolan, N., McCormick, P.A. Aliment. Pharmacol. Ther. (2004) [Pubmed]
  25. Is unrecognized anaphylaxis a cause of sudden unexpected death? Schwartz, H.J., Yunginger, J.W., Schwartz, L.B. Clin. Exp. Allergy (1995) [Pubmed]
  26. Treatment of subtrochanteric fractures of the femur: reduction on the traction table and fixation with dynamic condylar screw. Blatter, G., Janssen, M. Archives of orthopaedic and trauma surgery. (1994) [Pubmed]
  27. Comparison of seven commercial tests for the detection of parvovirus B19-specific IgM. Schwarz, T.F., Jäger, G., Gilch, S. Zentralbl. Bakteriol. (1997) [Pubmed]
  28. Increased mast cell density in peritoneal endometriosis compared with eutopic endometrium with endometriosis. Matsuzaki, S., Canis, M., Darcha, C., Fukaya, T., Yajima, A., Bruhat, M.A. Am. J. Reprod. Immunol. (1998) [Pubmed]
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