Gene Review:
PPP1R13B - protein phosphatase 1, regulatory subunit 13B
Homo sapiens
Synonyms:
ASPP1, Apoptosis-stimulating of p53 protein 1, KIAA0771, Protein phosphatase 1 regulatory subunit 13B, p53BP2-like, ...
- ASPP proteins specifically stimulate the apoptotic function of p53. Samuels-Lev, Y., O'Connor, D.J., Bergamaschi, D., Trigiante, G., Hsieh, J.K., Zhong, S., Campargue, I., Naumovski, L., Crook, T., Lu, X. Mol. Cell (2001)
- ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia. Agirre, X., Román-Gómez, J., Jiménez-Velasco, A., Garate, L., Montiel-Duarte, C., Navarro, G., Vázquez, I., Zalacain, M., Calasanz, M.J., Heiniger, A., Torres, A., Minna, J.D., Prósper, F. Oncogene (2006)
- The v-rel oncogene encodes a kappa B enhancer binding protein that inhibits NF-kappa B function. Ballard, D.W., Walker, W.H., Doerre, S., Sista, P., Molitor, J.A., Dixon, E.P., Peffer, N.J., Hannink, M., Greene, W.C. Cell (1990)
- Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Calon, F., Lim, G.P., Yang, F., Morihara, T., Teter, B., Ubeda, O., Rostaing, P., Triller, A., Salem, N., Ashe, K.H., Frautschy, S.A., Cole, G.M. Neuron (2004)
- Most of ADP x glucose linked to starch biosynthesis occurs outside the chloroplast in source leaves. Baroja-Fernández, E., Muñoz, F.J., Zandueta-Criado, A., Morán-Zorzano, M.T., Viale, A.M., Alonso-Casajús, N., Pozueta-Romero, J. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Abnormal G protein alpha(s) - and alpha(i2)-subunit mRNA expression in bipolar affective disorder. Spleiss, O., van Calker, D., Schärer, L., Adamovic, K., Berger, M., Gebicke-Haerter, P.J. Mol. Psychiatry (1998)
- LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Zhang, W., Sloan-Lancaster, J., Kitchen, J., Trible, R.P., Samelson, L.E. Cell (1998)
- Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Skolnik, E.Y., Margolis, B., Mohammadi, M., Lowenstein, E., Fischer, R., Drepps, A., Ullrich, A., Schlessinger, J. Cell (1991)
- Involvement of p85 in p53-dependent apoptotic response to oxidative stress. Yin, Y., Terauchi, Y., Solomon, G.G., Aizawa, S., Rangarajan, P.N., Yazaki, Y., Kadowaki, T., Barrett, J.C. Nature (1998)
- Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck. Eck, M.J., Shoelson, S.E., Harrison, S.C. Nature (1993)
- Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity. Yoakim, M., Hou, W., Songyang, Z., Liu, Y., Cantley, L., Schaffhausen, B. Mol. Cell. Biol. (1994)
- Loss of merlin-p85 protein complex in NF2-related tumors. Takeshima, H., Nishi, T., Yamamoto, K., Kino, T., Nakamura, H., Saya, H., Kochi, M., Kuratsu, J.I., Ushio, Y. Int. J. Oncol. (1998)
- Interleukin-6 receptor-interleukin-6 fusion proteins with enhanced interleukin-6 type pleiotropic activities. Chebath, J., Fischer, D., Kumar, A., Oh, J.W., Kolett, O., Lapidot, T., Fischer, M., Rose-John, S., Nagler, A., Slavin, S., Revel, M. Eur. Cytokine Netw. (1997)
- The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo. Thornton, J.K., Dalgleish, C., Venables, J.P., Sergeant, K.A., Ehrmann, I.E., Lu, X., Saunders, P.T., Elliott, D.J. Oncogene (2006)
- Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53. Liu, Z.J., Lu, X., Zhang, Y., Zhong, S., Gu, S.Z., Zhang, X.B., Yang, X., Xin, H.M. FEBS Lett. (2005)
- Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signaling. Gillham, H., Golding, M.C., Pepperkok, R., Gullick, W.J. J. Cell Biol. (1999)
- STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor. Pfeffer, L.M., Mullersman, J.E., Pfeffer, S.R., Murti, A., Shi, W., Yang, C.H. Science (1997)
- Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. Cusi, K., Maezono, K., Osman, A., Pendergrass, M., Patti, M.E., Pratipanawatr, T., DeFronzo, R.A., Kahn, C.R., Mandarino, L.J. J. Clin. Invest. (2000)
- Related GAP domains in inositol polyphosphate 5-phosphatase and the p85 subunit of phosphatidylinositol 3-kinase. Baldwin, G.S., Zhang, Q.X. Trends Biochem. Sci. (1993)
- Receptor-mediated endocytosis of albumin by kidney proximal tubule cells is regulated by phosphatidylinositide 3-kinase. Brunskill, N.J., Stuart, J., Tobin, A.B., Walls, J., Nahorski, S. J. Clin. Invest. (1998)
- PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells. Castoria, G., Migliaccio, A., Bilancio, A., Di Domenico, M., de Falco, A., Lombardi, M., Fiorentino, R., Varricchio, L., Barone, M.V., Auricchio, F. EMBO J. (2001)
- ASPP1 and ASPP2 are new transcriptional targets of E2F. Fogal, V., Kartasheva, N.N., Trigiante, G., Llanos, S., Yap, D., Vousden, K.H., Lu, X. Cell Death Differ. (2005)
- Some p53-binding proteins that can function as arbiters of life and death. Braithwaite, A.W., Del Sal, G., Lu, X. Cell Death Differ. (2006)
- p53 apoptotic pathway molecules are frequently and simultaneously altered in nonsmall cell lung carcinoma. Mori, S., Ito, G., Usami, N., Yoshioka, H., Ueda, Y., Kodama, Y., Takahashi, M., Fong, K.M., Shimokata, K., Sekido, Y. Cancer (2004)
- Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway. Bousquet, C., Guillermet-Guibert, J., Saint-Laurent, N., Archer-Lahlou, E., Lopez, F., Fanjul, M., Ferrand, A., Fourmy, D., Pichereaux, C., Monsarrat, B., Pradayrol, L., Estève, J.P., Susini, C. EMBO J. (2006)
- Interaction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes. Panayotou, G., Bax, B., Gout, I., Federwisch, M., Wroblowski, B., Dhand, R., Fry, M.J., Blundell, T.L., Wollmer, A., Waterfield, M.D. EMBO J. (1992)
- Jaks and Stats in signaling by the cytokine receptor superfamily. Ihle, J.N., Kerr, I.M. Trends Genet. (1995)
- Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain. Antonetti, D.A., Algenstaedt, P., Kahn, C.R. Mol. Cell. Biol. (1996)