Gene Review:
SIRT3 - sirtuin 3
Homo sapiens
Synonyms:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial, Regulatory protein SIR2 homolog 3, SIR2-like protein 3, SIR2L3, hSIRT3
- Altered sirtuin expression is associated with node-positive breast cancer. Ashraf, N., Zino, S., Macintyre, A., Kingsmore, D., Payne, A.P., George, W.D., Shiels, P.G. Br. J. Cancer (2006)
- The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. Schwer, B., North, B.J., Frye, R.A., Ott, M., Verdin, E. J. Cell Biol. (2002)
- Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Hallows, W.C., Lee, S., Denu, J.M. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Schwer, B., Bunkenborg, J., Verdin, R.O., Andersen, J.S., Verdin, E. Proc. Natl. Acad. Sci. U.S.A. (2006)
- A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Bellizzi, D., Rose, G., Cavalcante, P., Covello, G., Dato, S., De Rango, F., Greco, V., Maggiolini, M., Feraco, E., Mari, V., Franceschi, C., Passarino, G., De Benedictis, G. Genomics (2005)
- Metabolite of SIR2 reaction modulates TRPM2 ion channel. Grubisha, O., Rafty, L.A., Takanishi, C.L., Xu, X., Tong, L., Perraud, A.L., Scharenberg, A.M., Denu, J.M. J. Biol. Chem. (2006)
- Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13. Bellizzi, D., Dato, S., Cavalcante, P., Covello, G., Di Cianni, F., Passarino, G., Rose, G., De Benedictis, G. Genomics (2007)
- Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. Rose, G., Dato, S., Altomare, K., Bellizzi, D., Garasto, S., Greco, V., Passarino, G., Feraco, E., Mari, V., Barbi, C., BonaFe, M., Franceschi, C., Tan, Q., Boiko, S., Yashin, A.I., De Benedictis, G. Exp. Gerontol. (2003)
- SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Onyango, P., Celic, I., McCaffery, J.M., Boeke, J.D., Feinberg, A.P. Proc. Natl. Acad. Sci. U.S.A. (2002)