Gene Review:
HEY2 - hes-related family bHLH transcription...
Homo sapiens
Synonyms:
BHLHB32, CHF1, Cardiovascular helix-loop-helix factor 1, Class B basic helix-loop-helix protein 32, GRIDLOCK, ...
- Phenotypic variability in Hey2 -/- mice and absence of HEY2 mutations in patients with congenital heart defects or Alagille syndrome. Fischer, A., Klamt, B., Schumacher, N., Glaeser, C., Hansmann, I., Fenge, H., Gessler, M. Mamm. Genome (2004)
- ZFPM2/FOG2 and HEY2 genes analysis in nonsyndromic tricuspid atresia. Sarkozy, A., Conti, E., D'Agostino, R., Digilio, M.C., Formigari, R., Picchio, F., Marino, B., Pizzuti, A., Dallapiccola, B. Am. J. Med. Genet. A (2005)
- Homocysteine regulates expression of Herp by DNA methylation involving the AARE and CREB binding sites. Lenz, B., Bleich, S., Beutler, S., Schlierf, B., Schwager, K., Reulbach, U., Kornhuber, J., B??nsch, D. Exp. Cell Res. (2006)
- Relation of weight maintenance and dietary restraint to peroxisome proliferator-activated receptor gamma2, glucocorticoid receptor, and ciliary neurotrophic factor polymorphisms. Vogels, N., Mariman, E.C., Bouwman, F.G., Kester, A.D., Diepvens, K., Westerterp-Plantenga, M.S. Am. J. Clin. Nutr. (2005)
- The gene for an inherited form of deafness maps to chromosome 5q31. Leon, P.E., Raventos, H., Lynch, E., Morrow, J., King, M.C. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Williams, C.K., Li, J.L., Murga, M., Harris, A.L., Tosato, G. Blood (2006)
- Luman/CREB3 Induces Transcription of the Endoplasmic Reticulum (ER) Stress Response Protein Herp through an ER Stress Response Element. Liang, G., Audas, T.E., Li, Y., Cockram, G.P., Dean, J.D., Martyn, A.C., Kokame, K., Lu, R. Mol. Cell. Biol. (2006)
- Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family. Steidl, C., Leimeister, C., Klamt, B., Maier, M., Nanda, I., Dixon, M., Clarke, R., Schmid, M., Gessler, M. Genomics (2000)
- HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling. Iso, T., Sartorelli, V., Poizat, C., Iezzi, S., Wu, H.Y., Chung, G., Kedes, L., Hamamori, Y. Mol. Cell. Biol. (2001)
- Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors. Rutenberg, J.B., Fischer, A., Jia, H., Gessler, M., Zhong, T.P., Mercola, M. Development (2006)
- Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Diez, H., Fischer, A., Winkler, A., Hu, C.J., Hatzopoulos, A.K., Breier, G., Gessler, M. Exp. Cell Res. (2007)
- Dll4-selective Notch signaling induces ephrinB2 gene expression in endothelial cells. Iso, T., Maeno, T., Oike, Y., Yamazaki, M., Doi, H., Arai, M., Kurabayashi, M. Biochem. Biophys. Res. Commun. (2006)
- CHF1/Hey2 suppresses SM-MHC promoter activity through an interaction with GATA-6. Shirvani, S., Xiang, F., Koibuchi, N., Chin, M.T. Biochem. Biophys. Res. Commun. (2006)
- Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. Fischer, A., Klattig, J., Kneitz, B., Diez, H., Maier, M., Holtmann, B., Englert, C., Gessler, M. Mol. Cell. Biol. (2005)
- Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. Leimeister, C., Externbrink, A., Klamt, B., Gessler, M. Mech. Dev. (1999)
- Role of Herp in the endoplasmic reticulum stress response. Hori, O., Ichinoda, F., Yamaguchi, A., Tamatani, T., Taniguchi, M., Koyama, Y., Katayama, T., Tohyama, M., Stern, D.M., Ozawa, K., Kitao, Y., Ogawa, S. Genes Cells (2004)
- HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box. Doi, H., Iso, T., Yamazaki, M., Akiyama, H., Kanai, H., Sato, H., Kawai-Kowase, K., Tanaka, T., Maeno, T., Okamoto, E., Arai, M., Kedes, L., Kurabayashi, M. Arterioscler. Thromb. Vasc. Biol. (2005)
- HERP, a new primary target of Notch regulated by ligand binding. Iso, T., Sartorelli, V., Chung, G., Shichinohe, T., Kedes, L., Hamamori, Y. Mol. Cell. Biol. (2001)
- Epigenetic DNA hypermethylation of the HERP gene promoter induces down-regulation of its mRNA expression in patients with alcohol dependence. Bleich, S., Lenz, B., Ziegenbein, M., Beutler, S., Frieling, H., Kornhuber, J., Bönsch, D. Alcohol. Clin. Exp. Res. (2006)
- Interactions among the glucocorticoid receptor, lipoprotein lipase and adrenergic receptor genes and abdominal fat in the Québec Family Study. Ukkola, O., Pérusse, L., Chagnon, Y.C., Després, J.P., Bouchard, C. Int. J. Obes. Relat. Metab. Disord. (2001)