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Gene Review

RPL13A  -  ribosomal protein L13a

Homo sapiens

Synonyms: 23 kDa highly basic protein, 60S ribosomal protein L13a, L13A, TSTA1
 
 
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Disease relevance of RPL13A

  • The expressions of glyseraldehyde-3-phosphate dehydrogenase (GAPDH), beta-actin, cyclophilin, and RPL13A were examined in order to validate the appropriate housekeeping genes for a long duration after inducing cerebral ischemia [1].
 

High impact information on RPL13A

  • The proinflammatory cytokine interferon-gamma induces phosphorylation of ribosomal protein L13a and translocation from the 60S ribosomal subunit to the interferon-gamma-activated inhibitor of translation (GAIT) complex [2].
  • ACTB, RPL13A, and HMBS showed significant differences (P<0.02 at least) in expressions between malignant and nonmalignant pairs [3].
  • Gene organization and sequence of the region containing the ribosomal protein genes RPL13A and RPS11 in the human genome and conserved features in the mouse genome [4].
  • To determine a reliable stain for analysing RNA, using the housekeeping gene, RPL13A, we performed quantitative gene expression analysis of laser microdissected cells from prostatic frozen tissues [5].
  • The expression of RPL13A and SDHA appeared to be highly unstable [6].
 

Biological context of RPL13A

References

  1. The quantification of ADAMTS expression in an animal model of cerebral ischemia using real-time PCR. Tian, Y.F., Zhang, P.B., Xiao, X.L., Zhang, J.S., Zhao, J.J., Kang, Q.Y., Chen, X.L., Qiu, F., Liu, Y. Acta anaesthesiologica Scandinavica (2007) [Pubmed]
  2. L13a Blocks 48S Assembly: Role of a General Initiation Factor in mRNA-Specific Translational Control. Kapasi, P., Chaudhuri, S., Vyas, K., Baus, D., Komar, A.A., Fox, P.L., Merrick, W.C., Mazumder, B. Mol. Cell (2007) [Pubmed]
  3. Gene expression studies in prostate cancer tissue: which reference gene should be selected for normalization? Ohl, F., Jung, M., Xu, C., Stephan, C., Rabien, A., Burkhardt, M., Nitsche, A., Kristiansen, G., Loening, S.A., Radonić, A., Jung, K. J. Mol. Med. (2005) [Pubmed]
  4. Gene organization and sequence of the region containing the ribosomal protein genes RPL13A and RPS11 in the human genome and conserved features in the mouse genome. Higa, S., Yoshihama, M., Tanaka, T., Kenmochi, N. Gene (1999) [Pubmed]
  5. Influence of histochemical stains on quantitative gene expression analysis after laser-assisted microdissection. Okuducu, A.F., Janzen, V., Hahne, J.C., Ko, Y., Wernert, N. Int. J. Mol. Med. (2003) [Pubmed]
  6. Development of a new set of reference genes for normalization of real-time RT-PCR data of porcine backfat and longissimus dorsi muscle, and evaluation with PPARGC1A. Erkens, T., Van Poucke, M., Vandesompele, J., Goossens, K., Van Zeveren, A., Peelman, L.J. BMC Biotechnol. (2006) [Pubmed]
  7. High-resolution mapping of ribosomal protein genes to human chromosome 19. Kenmochi, N., Ashworth, L.K., Lennon, G., Higa, S., Tanaka, T. DNA Res. (1998) [Pubmed]
  8. Ribosomal highly basic 23-kDa protein as a reliable standard for gene expression analysis. Jesnowski, R., Backhaus, C., Ringel, J., Löhr, M. Pancreatology (2002) [Pubmed]
  9. Ribosomal proteins in cell proliferation and apoptosis. Chen, F.W., Ioannou, Y.A. Int. Rev. Immunol. (1999) [Pubmed]
 
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