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KAT6B  -  K(lysine) acetyltransferase 6B

Homo sapiens

 
 
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Disease relevance of MYST4

 

Psychiatry related information on MYST4

  • Currently prominent models of narcissism (e.g., Morf and Rhodewalt, 2001) primarily explain narcissists' self-defeating behaviors in terms of conscious cognitive and affective processes [4].
  • No significant differences were found between conversion disorder patients and controls in PHLL, PHLR, PLRP, and MORF [5].
 

High impact information on MYST4

 

Biological context of MYST4

  • Variant MYST4-CBP gene fusion in a t(10;16) acute myeloid leukaemia [9].
  • Moreover, endogenous MORF is required for transcriptional activation by Runx2 [10].
  • Genomic analyses revealed that the breaks were close to Alu elements in intron 16 of MORF and intron 2 of CBP and that duplications had occurred near the breakpoints [1].
  • Here, we report a new case with the MORF-CREBBP fusion in an 84-year-old patient diagnosed with AML M5b, in which the t(10;16)(q22;p13) was the only cytogenetic aberration [11].
  • In conclusion, a bivalent MORF was easily synthesized by dimerization of a monovalent MORF [12].
 

Anatomical context of MYST4

  • The present study reports a method to construct a chimera of phosphorodiamidate morpholino nucleobase oligomer (MORF) covalently conjugated to a peptide containing a cell membrane transduction Tat peptide and an N(2)S(2) chelator for technetium-99m ((99m)Tc) radiolabeling (N(2)S(2)-Tat-MORF) [13].
 

Associations of MYST4 with chemical compounds

 

Other interactions of MYST4

  • The monocytic leukemia zinc finger protein MOZ and its homologue MORF have been implicated in leukemogenesis [10].
  • These methods are useful not only for functional characterization of MOZ, MORF, PCAF, and other HATs, but also for preparation of HAT proteins to screen compound libraries and obtain inhibitors with potential therapeutic value [15].
 

Analytical, diagnostic and therapeutic context of MYST4

  • By surface plasmon resonance at room temperature, the association rate constant for hybridization of the 18-mer MORF to its complementary oligomer (cMORF) was equivalent to that of DNAs and PNAs of comparable length [16].
  • In each case, the labeled MORFs showed one sharp peak in HPLC that shifted completely to earlier retention times following addition of a polymer conjugated with the complementary MORF [17].

References

  1. Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13). Panagopoulos, I., Fioretos, T., Isaksson, M., Samuelsson, U., Billström, R., Strömbeck, B., Mitelman, F., Johansson, B. Hum. Mol. Genet. (2001) [Pubmed]
  2. A novel fusion variant of the MORF and CBP genes detected in therapy-related myelodysplastic syndrome with t(10;16)(q22;p13). Kojima, K., Kaneda, K., Yoshida, C., Dansako, H., Fujii, N., Yano, T., Shinagawa, K., Yasukawa, M., Fujita, S., Tanimoto, M. Br. J. Haematol. (2003) [Pubmed]
  3. The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Yang, X.J. Nucleic Acids Res. (2004) [Pubmed]
  4. Impulsivity and the self-defeating behavior of narcissists. Vazire, S., Funder, D.C. Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc. (2006) [Pubmed]
  5. EEG frequency analysis in conversion and somatoform disorder. Drake, M.E., Padamadan, H., Pakalnis, A. Clinical EEG (electroencephalography). (1988) [Pubmed]
  6. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Doyon, Y., Cayrou, C., Ullah, M., Landry, A.J., Côté, V., Selleck, W., Lane, W.S., Tan, S., Yang, X.J., Côté, J. Mol. Cell (2006) [Pubmed]
  7. Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF. Moore, S.D., Herrick, S.R., Ince, T.A., Kleinman, M.S., Cin, P.D., Morton, C.C., Quade, B.J. Cancer Res. (2004) [Pubmed]
  8. Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein. Champagne, N., Bertos, N.R., Pelletier, N., Wang, A.H., Vezmar, M., Yang, Y., Heng, H.H., Yang, X.J. J. Biol. Chem. (1999) [Pubmed]
  9. Variant MYST4-CBP gene fusion in a t(10;16) acute myeloid leukaemia. Murati, A., Adélaïde, J., Mozziconacci, M.J., Popovici, C., Carbuccia, N., Letessier, A., Birg, F., Birnbaum, D., Chaffanet, M. Br. J. Haematol. (2004) [Pubmed]
  10. MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2. Pelletier, N., Champagne, N., Stifani, S., Yang, X.J. Oncogene (2002) [Pubmed]
  11. t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia. Vizmanos, J.L., Larráyoz, M.J., Lahortiga, I., Floristán, F., Alvarez, C., Odero, M.D., Novo, F.J., Calasanz, M.J. Genes Chromosomes Cancer (2003) [Pubmed]
  12. Affinity enhancement bivalent morpholino for pretargeting: initial evidence by surface plasmon resonance. He, J., Liu, G., Vanderheyden, J.L., Dou, S., Mary, R., Hnatowich, D.J. Bioconjug. Chem. (2005) [Pubmed]
  13. Construction of a novel chimera consisting of a chelator-containing Tat peptide conjugated to a morpholino antisense oligomer for technetium-99m labeling and accelerating cellular kinetics. Zhang, Y.M., Tung, C.H., He, J., Liu, N., Yanachkov, I., Liu, G., Rusckowski, M., Vanderheyden, J.L. Nucl. Med. Biol. (2006) [Pubmed]
  14. Improving the labeling of S-acetyl NHS-MAG(3)-conjugated morpholino oligomers. Liu, G., Zhang, S., He, J., Zhu, Z., Rusckowski, M., Hnatowich, D.J. Bioconjug. Chem. (2002) [Pubmed]
  15. Expression, purification, and analysis of MOZ and MORF histone acetyltransferases. Pelletier, N., Champagne, N., Lim, H., Yang, X.J. Methods (2003) [Pubmed]
  16. Initial investigations of 99mTc-labeled morpholinos for radiopharmaceutical applications. Mang'era, K.O., Liu, G., Yi, W., Zhang, Y., Liu, N., Gupta, S., Rusckowski, M., Hnatowich, D.J. European journal of nuclear medicine. (2001) [Pubmed]
  17. Radiolabeling morpholinos with 90Y, 111In, 188Re and 99mTc. Liu, C.B., Liu, G.Z., Liu, N., Zhang, Y.M., He, J., Rusckowski, M., Hnatowich, D.J. Nucl. Med. Biol. (2003) [Pubmed]
 
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