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ADAT1  -  adenosine deaminase, tRNA-specific 1

Homo sapiens

Synonyms: hADAT1, tRNA-specific adenosine deaminase 1, tRNA-specific adenosine-37 deaminase
 
 
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Psychiatry related information on ADAT1

  • Patients with a schizoaffective disorder both experienced that they had less access to (AVAT) and were less satisfied with their deep emotional relations (ADAT) [1].
 

High impact information on ADAT1

  • We report here the identification and characterization of a human ADAR protein, hADAT1, that specifically deaminates adenosine 37 to inosine in eukaryotic tRNA(Ala) [2].
  • Significant sequence similarities between KARS and ADAT1 are apparent within their substrate interaction domains [3].
  • In the present study we have analyzed the 5'-flanking sequence of the murine ADAT1 gene, revealing that the first transcribed exon is located 1.1 kb downstream from the polyadenylation site of lysyl tRNA synthetase (KARS) [3].
  • Human tRNA-specific adenosine deaminase (hADAT1) specifically converts A37 in the anticodon loop of human tRNA(Ala) to inosine via a hydrolytic deamination mechanism [3].
  • Indeed, IP6 is also essential for in vivo and in vitro deamination of adenosine 37 of tRNAala by ADAT1 [4].
 

Biological context of ADAT1

  • The hADAT1 cDNA predicts a protein of 502 aa whose sequence displays strongest overall homology to a Drosophila melanogaster ORF (50% similarity, 32% identity), and the catalytic domain is closely related to the other ADAR proteins [2].
  • The kinetics of the ADAT can be either conventional (exponential) or anomalous (of inverse power type) for different parameters of the model and time [5].
 

Analytical, diagnostic and therapeutic context of ADAT1

References

  1. The social network of patients with schizoaffective disorder as compared to healthy individuals. Nettelbladt, P., Svensson, C., Serin, U., Ojehagen, A. Social science & medicine (1982) (1995) [Pubmed]
  2. Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes. Maas, S., Gerber, A.P., Rich, A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. Genomic clustering of tRNA-specific adenosine deaminase ADAT1 and two tRNA synthetases. Maas, S., Kim, Y.G., Rich, A. Mamm. Genome (2001) [Pubmed]
  4. Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing. Macbeth, M.R., Schubert, H.L., Vandemark, A.P., Lingam, A.T., Hill, C.P., Bass, B.L. Science (2005) [Pubmed]
  5. Anomalous two-state model for anomalous diffusion. Shushin, A.I. Physical review. E, Statistical, nonlinear, and soft matter physics . (2001) [Pubmed]
  6. Self-reported appetite, hospitalization and death in haemodialysis patients: findings from the Hemodialysis (HEMO) Study. Burrowes, J.D., Larive, B., Chertow, G.M., Cockram, D.B., Dwyer, J.T., Greene, T., Kusek, J.W., Leung, J., Rocco, M.V. Nephrol. Dial. Transplant. (2005) [Pubmed]
 
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