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KLHDC2  -  kelch domain containing 2

Homo sapiens

Synonyms: HCA33, HCLP-1, HCLP1, Hepatocellular carcinoma-associated antigen 33, Host cell factor homolog LCP, ...
 
 
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Disease relevance of KLHDC2

  • Electrophysiologic studies were performed in 28 patients with documented atrioventricular (AV) nodal reentrant supraventricular tachycardia (SVT) to investigate the presence of AV nodal tissue situated between the tachycardia circuit and both the atrium (upper common pathway, UCP) and the His bundle (lower common pathway, LCP) [1].
  • CD56+/CD3- NK purified by fluorescence-activated cell sorting from 21 patients (7 early chronic phase [ECP] patients, 10 late chronic and accelerated phase [LCP/AP], and 4 blast crisis [BC] patients) were studied [2].
  • In macrophages derived from most mouse strains, the LCP is delivered to the lysosome resulting in Legionella degradation and restricted bacterial growth [3].
  • Lipoamino acid-based synthetic peptides (lipid core peptides, LCP) derived from the type-specific and conserved region determinants of group A streptococci (GAS) were evaluated as potential candidate sequences in a vaccine to prevent GAS-associated diseases, including rheumatic heart disease and poststreptococcal acute glomerulonephritis [4].
  • Using matched populations of 22 lung cancer patients who have been cigarette smokers (LCP), 22 non-cancerous cigarette smokers (SC) and 13 non-smokers (NSC), we have applied the fluorescence in situ hybridization (FISH) tanden probe assay to elucidate the frequency of chromosome breakage among the participants [5].
 

High impact information on KLHDC2

 

Chemical compound and disease context of KLHDC2

  • It is suggested that the lower concentrations of LCP in combined pill users may affect membrane function and prostaglandin synthesis and may relate to their increased risk of thrombosis [7].
 

Biological context of KLHDC2

  • OBJECTIVE: The aim was to investigate maternal plasma and erythrocyte long-chain polyunsaturated fatty acids (long-chain polyenes; LCPs) postpartum, particularly DHA, in relation to lactation and dietary LCP intake [8].
  • OBJECTIVE: We evaluated LCP supplementation in amounts typical for human milk (based on local and worldwide surveys) in a large cohort of infants by using sweep visual evoked potential (VEP) acuity as the functional outcome [9].
  • The increased liver and brain n-6 LCP accretion in the FF piglets may suggest competent desaturation and possible inhibition of n-3 desaturation and/or acylation by dietary n-6 fatty acids [10].
  • We conclude that activation of caspase-3 by the Dot/Icm virulence system of L. pneumophila is essential for halting biogenesis of the LCP through the endosomal/lysosomal pathway, and that this is associated with the cleavage of Rabpatin-5 [11].
  • The present study was designed to evaluate the effect of gestational age and intrauterine growth on the long chain polyunsaturated fatty acid (LCP) synthesis from dietary precursors in neonates as reflected by plasma pools [12].
 

Anatomical context of KLHDC2

  • CONCLUSION: LCP supplementation of term infant formula during the first year of life yields clear differences in visual function and in total red blood cell lipid composition [9].
  • Overexpression of Kelch domain containing-2 (mKlhdc2) inhibits differentiation and directed migration of C2C12 myoblasts [13].
  • The Legionella-containing phagosome (LCP) does not acquire any endocytic markers and is remodeled by the endoplasmic reticulum during early stages [14].
  • After a correction for gestational age at birth, significant relations (p < or = 0.05) were observed between anthropometric measurements at birth (weight, head circumference, and length) and LCP levels in the umbilical artery wall, the LCP content of which reflects the long-term fetal LCP status [15].
  • Compared with Formula alone, adding LCP to formula resulted in a lower C18:2n-6 and higher C20:4n-6 content in lymphocyte phospholipids (P < 0.05) [16].
 

Associations of KLHDC2 with chemical compounds

 

Other interactions of KLHDC2

  • Thus, HCLP-1 serves a transcriptional co-repressor function mediated through its inhibitory interaction with the LZIP transcription factor [6].
 

Analytical, diagnostic and therapeutic context of KLHDC2

References

  1. Atrioventricular nodal reentrant tachycardia: studies on upper and lower 'common pathways'. Miller, J.M., Rosenthal, M.E., Vassallo, J.A., Josephson, M.E. Circulation (1987) [Pubmed]
  2. CD56+bright and CD56+dim natural killer cells in patients with chronic myelogenous leukemia progressively decrease in number, respond less to stimuli that recruit clonogenic natural killer cells, and exhibit decreased proliferation on a per cell basis. Pierson, B.A., Miller, J.S. Blood (1996) [Pubmed]
  3. Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf. Amer, A., Franchi, L., Kanneganti, T.D., Body-Malapel, M., Oz??ren, N., Brady, G., Meshinchi, S., Jagirdar, R., Gewirtz, A., Akira, S., N????ez, G. J. Biol. Chem. (2006) [Pubmed]
  4. Lipoamino acid-based adjuvant carrier system: enhanced immunogenicity of group a streptococcal peptide epitopes. Horvath, A., Olive, C., Wong, A., Clair, T., Yarwood, P., Good, M., Toth, I. J. Med. Chem. (2002) [Pubmed]
  5. Predisposing genes and increased chromosome aberrations in lung cancer cigarette smokers. Conforti-Froes, N., el-Zein, R., Abdel-Rahman, S.Z., Zwischenberger, J.B., Au, W.W. Mutat. Res. (1997) [Pubmed]
  6. Inhibition of LZIP-mediated transcription through direct interaction with a novel host cell factor-like protein. Zhou, H.J., Wong, C.M., Chen, J.H., Qiang, B.Q., Yuan, J.G., Jin, D.Y. J. Biol. Chem. (2001) [Pubmed]
  7. Plasma and erythrocyte membrane fatty acids in oral contraceptive users. Fehily, A.M., Dickerson, J.W., Meade, B.W., Ellis, F.R. Clin. Chim. Acta (1982) [Pubmed]
  8. Comparison of the peripartum and postpartum phospholipid polyunsaturated fatty acid profiles of lactating and nonlactating women. Otto, S.J., van Houwelingen, A.C., Badart-Smook, A., Hornstra, G. Am. J. Clin. Nutr. (2001) [Pubmed]
  9. Visual maturation of term infants fed long-chain polyunsaturated fatty acid-supplemented or control formula for 12 mo. Birch, E.E., Castañeda, Y.S., Wheaton, D.H., Birch, D.G., Uauy, R.D., Hoffman, D.R. Am. J. Clin. Nutr. (2005) [Pubmed]
  10. Effect of a vegetable oil formula rich in linoleic acid on tissue fatty acid accretion in the brain, liver, plasma, and erythrocytes of infant piglets. Hrboticky, N., MacKinnon, M.J., Innis, S.M. Am. J. Clin. Nutr. (1990) [Pubmed]
  11. Activation of caspase-3 by the Dot/Icm virulence system is essential for arrested biogenesis of the Legionella-containing phagosome. Molmeret, M., Zink, S.D., Han, L., Abu-Zant, A., Asari, R., Bitar, D.M., Abu Kwaik, Y. Cell. Microbiol. (2004) [Pubmed]
  12. Long chain polyunsaturated fatty acid formation in neonates: effect of gestational age and intrauterine growth. Uauy, R., Mena, P., Wegher, B., Nieto, S., Salem, N. Pediatr. Res. (2000) [Pubmed]
  13. Overexpression of Kelch domain containing-2 (mKlhdc2) inhibits differentiation and directed migration of C2C12 myoblasts. Neuhaus, P., Jaschinsky, B., Schneider, S., Neuhaus, H., Wolter, A., Ebelt, H., Braun, T. Exp. Cell Res. (2006) [Pubmed]
  14. Maturation of the Legionella pneumophila-containing phagosome into a phagolysosome within gamma interferon-activated macrophages. Santic, M., Molmeret, M., Abu Kwaik, Y. Infect. Immun. (2005) [Pubmed]
  15. Long-chain polyunsaturated fatty acids in preterm infants: status at birth and its influence on postnatal levels. Foreman-van Drongelen, M.M., van Houwelingen, A.C., Kester, A.D., Hasaart, T.H., Blanco, C.E., Hornstra, G. J. Pediatr. (1995) [Pubmed]
  16. Lower proportion of CD45R0+ cells and deficient interleukin-10 production by formula-fed infants, compared with human-fed, is corrected with supplementation of long-chain polyunsaturated fatty acids. Field, C.J., Thomson, C.A., Van Aerde, J.E., Parrott, A., Euler, A., Lien, E., Clandinin, M.T. J. Pediatr. Gastroenterol. Nutr. (2000) [Pubmed]
  17. Influence of long chain unsaturated fatty acids in formula feeds on lipid peroxidation and antioxidants in preterm infants. Jacobs, N.J., van Zoeren-Grobben, D., Drejer, G.F., Bindels, J.G., Berger, H.M. Pediatr. Res. (1996) [Pubmed]
  18. Short-term diets rich in arachidonic acid influence plasma phospholipid polyunsaturated fatty acid levels and prostacyclin and thromboxane production in humans. Sinclair, A.J., Mann, N.J. J. Nutr. (1996) [Pubmed]
  19. The fatty acid composition of human milk in Europe and Africa. Koletzko, B., Thiel, I., Abiodun, P.O. J. Pediatr. (1992) [Pubmed]
  20. Prostanoid formation during feeding of a preterm formula with long-chain polyunsaturated fatty acids in healthy preterm infants during the first weeks of life. Stier, C., Hess, M., Watzer, B., Schweer, H., Seyberth, H.W., Leonhardt, A. Pediatr. Res. (1997) [Pubmed]
 
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