High impact information on Xcr1

• Lymphotactin expression by engineered myeloma cells drives tumor regression: mediation by CD4+ and CD8+ T cells and neutrophils expressing XCR1 receptor [1].
• Our data also indicate that mouse neutrophils express the lymphotactin receptor XCR1 and that lymphotactin specifically chemoattracts these cells in vitro [1].
• Thus, this study is the first demonstration of a chemotactic effect of Lptn on neutrophils and confirms the association of this effect with expression of the XCR1 receptor on these cells [2].
• Neutrophils and B cells express XCR1 receptor and chemotactically respond to lymphotactin [2].
• In this study we investigated (i) the chemotactic influences of Lptn on T and B lymphocytes, neutrophils, monocytes, and dendritic cells, and (ii) the expression of the Lptn receptor (XCR1) by these cells, using RT-PCR [2].

Other interactions of Xcr1

• Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor [3].

References