Gene Review:
Apc - adenomatous polyposis coli
Rattus norvegicus
Synonyms:
Adenomatous polyposis coli protein, Protein APC
- Carcinogenicity of aminophenylnorharman, a possible novel endogenous mutagen, formed from norharman and aniline, in F344 rats. Kawamori, T., Totsuka, Y., Uchiya, N., Kitamura, T., Shibata, H., Sugimura, T., Wakabayashi, K. Carcinogenesis (2004)
- Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein. Zhang, F., White, R.L., Neufeld, K.L. Mol. Cell. Biol. (2001)
- Proteomic analysis of intestinal epithelial cells expressing stabilized beta-catenin. Seike, M., Kondo, T., Mori, Y., Gemma, A., Kudoh, S., Sakamoto, M., Yamada, T., Hirohashi, S. Cancer Res. (2003)
- Mutations of adenomatous polyposis coli and beta-catenin genes during progression of lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Tsujiuchi, T., Tsutsumi, M., Sasaki, Y., Murata, N., Konishi, Y. Cancer Res. (2000)
- Adenomatous polyposis coli protein is expressed in alternate stages of the ameloblast life cycle. Wang, M., Dobeck, J.M., Sorkin, B.C., Skobe, Z. J. Dent. Res. (1998)
- Increase of adenomatous polyposis coli immunoreactivity is a marker of reactive astrocytes in Alzheimer's disease and in other pathological conditions. Leroy, K., Duyckaerts, C., Bovekamp, L., Müller, O., Anderton, B.H., Brion, J.P. Acta Neuropathol. (2001)
- Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Etienne-Manneville, S., Hall, A. Nature (2003)
- Effects of dietary folate on DNA strand breaks within mutation-prone exons of the p53 gene in rat colon. Kim, Y.I., Shirwadkar, S., Choi, S.W., Puchyr, M., Wang, Y., Mason, J.B. Gastroenterology (2000)
- The effect of dietary folate on Apc and p53 mutations in the dimethylhydrazine rat model of colorectal cancer. Sohn, K.J., Puchyr, M., Salomon, R.N., Graeme-Cook, F., Fung, L., Choi, S.W., Mason, J.B., Medline, A., Kim, Y.I. Carcinogenesis (1999)
- Do NSAIDs exert their colon cancer chemoprevention activities through the inhibition of mucosal prostaglandin synthetase? Alberts, D.S., Hixson, L., Ahnen, D., Bogert, C., Einspahr, J., Paranka, N., Brendel, K., Gross, P.H., Pamukcu, R., Burt, R.W. J. Cell. Biochem. Suppl. (1995)
- Beta-catenin, an inducer of uncontrolled cell proliferation and migration in malignancies, is localized in the cytoplasm of vascular endothelium during neovascularization after myocardial infarction. Blankesteijn, W.M., van Gijn, M.E., Essers-Janssen, Y.P., Daemen, M.J., Smits, J.F. Am. J. Pathol. (2000)
- Subcellular localization of the tumor suppressor protein APC in developing cultured neurons. Shimomura, A., Kohu, K., Akiyama, T., Senda, T. Neurosci. Lett. (2005)
- Cdc42 and Par6-PKCzeta regulate the spatially localized association of Dlg1 and APC to control cell polarization. Etienne-Manneville, S., Manneville, J.B., Nicholls, S., Ferenczi, M.A., Hall, A. J. Cell Biol. (2005)
- Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. Blum, C.A., Tanaka, T., Zhong, X., Li, Q., Dashwood, W.M., Pereira, C., Xu, M., Dashwood, R.H. Mol. Carcinog. (2003)
- Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Kakiuchi, H., Watanabe, M., Ushijima, T., Toyota, M., Imai, K., Weisburger, J.H., Sugimura, T., Nagao, M. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Mutations of the Apc gene in experimental colorectal carcinogenesis induced by azoxymethane in F344 rats. De Filippo, C., Caderni, G., Bazzicalupo, M., Briani, C., Giannini, A., Fazi, M., Dolara, P. Br. J. Cancer (1998)
- The influence of 1-aminocyclopentane-1-carboxylic acid at position 2 or 3 of AVP and its analogues on their pharmacological properties. Kowalczyk, W., Prahl, A., Dawidowska, O., Derdowska, I., Sobolewski, D., Hartrodt, B., Neubert, K., Slaninová, J., Lammek, B. J. Pept. Sci. (2005)
- Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration. Monga, S.P., Pediaditakis, P., Mule, K., Stolz, D.B., Michalopoulos, G.K. Hepatology (2001)
- Strain differences of rats in the susceptibility to aberrant crypt foci formation by 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine: no implication of Apc and Pla2g2a genetic polymorphisms in differential susceptibility. Ishiguro, Y., Ochiai, M., Sugimura, T., Nagao, M., Nakagama, H. Carcinogenesis (1999)
- Suppression of beta-catenin by antisense oligomers augments tumor response to isolated limb perfusion in a rodent model of adenomatous polyposis coli-mutant colon cancer. Canter, R.J., Kesmodel, S.B., Heitjan, D.F., Veeramachaneni, N.K., Mokadam, N.A., Drebin, J.A., Fraker, D.L. Ann. Surg. Oncol. (2005)
- How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men. Corpet, D.E., Pierre, F. Eur. J. Cancer (2005)
- Absence of PhIP adducts, p53 and Apc mutations, in rats fed a cooked beef diet containing a high level of heterocyclic amines. Shen, C.L., Purewal, M., San Francisco, S., Pence, B.C. Nutrition and cancer. (1998)
- Modeling human colon cancer in rodents using a food-borne carcinogen, PhIP. Nakagama, H., Nakanishi, M., Ochiai, M. Cancer Sci. (2005)