Gene Review:
Nos2 - nitric oxide synthase 2, inducible
Rattus norvegicus
Synonyms:
Inducible NO synthase, Inducible NOS, NOS type II, Nitric oxide synthase, inducible, Nos2a, ...
- Homocysteine-induced nitric oxide production in vascular smooth-muscle cells by NF-kappa B-dependent transcriptional activation of Nos2. Welch, G.N., Upchurch, G.R., Farivar, R.S., Pigazzi, A., Vu, K., Brecher, P., Keaney, J.F., Loscalzo, J. Proc. Assoc. Am. Physicians (1998)
- Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite. Szabó, C., Zingarelli, B., Salzman, A.L. Circ. Res. (1996)
- Bilirubin inhibits iNOS expression and NO production in response to endotoxin in rats. Wang, W.W., Smith, D.L., Zucker, S.D. Hepatology (2004)
- Expression and localization of inducible nitric oxide synthase in anti-Thy-1 glomerulonephritis. Goto, S., Yamamoto, T., Feng, L., Yaoita, E., Hirose, S., Fujinaka, H., Kawasaki, K., Hattori, R., Yui, Y., Wilson, C.B. Am. J. Pathol. (1995)
- Alterations of nitric oxide synthase expression with aging and hypertension in rats. Chou, T.C., Yen, M.H., Li, C.Y., Ding, Y.A. Hypertension (1998)
- Factors Involved in Upregulation of Inducible Nitric Oxide Synthase in Rat Small Intestine Following Administration of Nonsteroidal Anti-inflammatory Drugs. Takeuchi, K., Yokota, A., Tanaka, A., Takahira, Y. Dig. Dis. Sci. (2006)
- The effects of alpha-lipoic acid on nitric oxide synthetase dispersion in penile function in streptozotocin-induced diabetic rats. Hurdag, C., Ozkara, H., Citci, S., Uyaner, I., Demirci, C. International journal of tissue reactions. (2005)
- Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo. Heneka, M.T., Klockgether, T., Feinstein, D.L. J. Neurosci. (2000)
- Heroin modulates the expression of inducible nitric oxide synthase. Lysle, D.T., How, T. Immunopharmacology (2000)
- Inducible nitric oxide synthase gene expression in the brain during systemic inflammation. Wong, M.L., Rettori, V., al-Shekhlee, A., Bongiorno, P.B., Canteros, G., McCann, S.M., Gold, P.W., Licinio, J. Nat. Med. (1996)
- Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase. Corbett, J.A., McDaniel, M.L. J. Exp. Med. (1995)
- Prevention of gram-negative translocation reduces the severity of hepatopulmonary syndrome. Rabiller, A., Nunes, H., Lebrec, D., Tazi, K.A., Wartski, M., Dulmet, E., Libert, J.M., Mougeot, C., Moreau, R., Mazmanian, M., Humbert, M., Hervé, P. Am. J. Respir. Crit. Care Med. (2002)
- Chronic liver injury alters basal and stimulated nitric oxide production and 3H-thymidine incorporation in cultured sinusoidal endothelial cells from rats. Petermann, H., Vogl, S., Schulze, E., Dargel, R. J. Hepatol. (1999)
- An octamer motif is required for activation of the inducible nitric oxide synthase promoter in pancreatic beta-cells. Darville, M.I., Terryn, S., Eizirik, D.L. Endocrinology (2004)
- Selective cannabinoid CB1 receptor-mediated inhibition of inducible nitric oxide synthase protein expression in C6 rat glioma cells. Esposito, G., Izzo, A.A., Di Rosa, M., Iuvone, T. J. Neurochem. (2001)
- Expression of nitric oxide synthases and GTP cyclohydrolase I in the ventilatory and limb muscles during endotoxemia. Hussain, S.N., Giaid, A., El Dawiri, Q., Sakkal, D., Hattori, R., Guo, Y. Am. J. Respir. Cell Mol. Biol. (1997)
- Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. Deng, A.Y., Rapp, J.P. J. Clin. Invest. (1995)
- Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells. Larsen, L., Størling, J., Darville, M., Eizirik, D.L., Bonny, C., Billestrup, N., Mandrup-Poulsen, T. Diabetologia (2005)
- Identification of cis-regulatory regions necessary for robust Nos2 promoter activity in glial cells: indirect role for NF-kappaB. Sanchez, A.C., Davis, R.L., Syapin, P.J. J. Neurochem. (2003)
- Decreased renal expression of nitric oxide synthase isoforms in adrenocorticotropin-induced and corticosterone-induced hypertension. Lou , Y.K., Wen, C., Li, M., Adams, D.J., Wang , M.X., Yang, F., Morris, B.J., Whitworth, J.A. Hypertension (2001)
- Inducible nitric oxide synthase in rat hepatic lipocytes and the effect of nitric oxide on lipocyte contractility. Rockey, D.C., Chung, J.J. J. Clin. Invest. (1995)
- Induction of nitric oxide synthase activity by cytokines in ventricular myocytes is necessary but not sufficient to decrease contractile responsiveness to beta-adrenergic agonists. Ungureanu-Longrois, D., Balligand, J.L., Simmons, W.W., Okada, I., Kobzik, L., Lowenstein, C.J., Kunkel, S.L., Michel, T., Kelly, R.A., Smith, T.W. Circ. Res. (1995)
- Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging rats. Cernadas, M.R., Sánchez de Miguel, L., García-Durán, M., González-Fernández, F., Millás, I., Montón, M., Rodrigo, J., Rico, L., Fernández, P., de Frutos, T., Rodríguez-Feo, J.A., Guerra, J., Caramelo, C., Casado, S., López-Farré, n.u.l.l. Circ. Res. (1998)
- Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated by inducible NOS after lipopolysaccharide administration provokes renal dysfunction in rats. Schwartz, D., Mendonca, M., Schwartz, I., Xia, Y., Satriano, J., Wilson, C.B., Blantz, R.C. J. Clin. Invest. (1997)
- An autoinhibitory control element defines calcium-regulated isoforms of nitric oxide synthase. Salerno, J.C., Harris, D.E., Irizarry, K., Patel, B., Morales, A.J., Smith, S.M., Martasek, P., Roman, L.J., Masters, B.S., Jones, C.L., Weissman, B.A., Lane, P., Liu, Q., Gross, S.S. J. Biol. Chem. (1997)
- In-vitro and in-vivo anti-inflammatory effect of oxyresveratrol from Morus alba L. Chung, K.O., Kim, B.Y., Lee, M.H., Kim, Y.R., Chung, H.Y., Park, J.H., Moon, J.O. J. Pharm. Pharmacol. (2003)
- Aging-related increased expression of inducible nitric oxide synthase and cytotoxicity markers in rat hypothalamic regions associated with male reproductive function. Ferrini, M., Wang, C., Swerdloff, R.S., Sinha Hikim, A.P., Rajfer, J., Gonzalez-Cadavid, N.F. Neuroendocrinology (2001)
- Induction of endothelial nitric-oxide synthase in rat brain astrocytes by systemic lipopolysaccharide treatment. Iwase, K., Miyanaka, K., Shimizu, A., Nagasaki, A., Gotoh, T., Mori, M., Takiguchi, M. J. Biol. Chem. (2000)
- Angiotensin II differentially regulates interleukin-1-beta-inducible NO synthase (iNOS) and vascular cell adhesion molecule-1 (VCAM-1) expression: role of p38 MAPK. Jiang, B., Xu, S., Hou, X., Pimentel, D.R., Cohen, R.A. J. Biol. Chem. (2004)
- Oxidative stress induces vascular heme oxygenase-1 expression in ovariectomized rats. Lee, Y.M., Cheng, P.Y., Hong, S.F., Chen, S.Y., Lam, K.K., Sheu, J.R., Yen, M.H. Free Radic. Biol. Med. (2005)
- Induction of guanosine triphosphate-cyclohydrolase by follicle-stimulating hormone enhances interleukin-1 beta-stimulated nitric oxide synthase activity in granulosa cells. Tabraue, C., Diaz Peñate, R., Gallardo, G., Hernandez, I., Quintana, J., Lopez Blanco, F., Gonzalez Reyes, J., Fanjul, L.F., Ruiz de Galarreta, C.M. Endocrinology (1997)
- Endothelin-1 inhibits cytokine-stimulated transcription of inducible nitric oxide synthase in glomerular mesangial cells. Beck, K.F., Mohaupt, M.G., Sterzel, R.B. Kidney Int. (1995)
- Contractile responsiveness of ventricular myocytes to isoproterenol is regulated by induction of nitric oxide synthase activity in cardiac microvascular endothelial cells in heterotypic primary culture. Ungureanu-Longrois, D., Balligand, J.L., Okada, I., Simmons, W.W., Kobzik, L., Lowenstein, C.J., Kunkel, S.L., Michel, T., Kelly, R.A., Smith, T.W. Circ. Res. (1995)
- The role of endothelin-1 and the endothelin B receptor in the pathogenesis of hepatopulmonary syndrome in the rat. Ling, Y., Zhang, J., Luo, B., Song, D., Liu, L., Tang, L., Stockard, C.R., Grizzle, W.E., Ku, D.D., Fallon, M.B. Hepatology (2004)
- Activation of retinoic X receptor and peroxisome proliferator-activated receptor-gamma inhibits nitric oxide and tumor necrosis factor-alpha production in rat Kupffer cells. Uchimura, K., Nakamuta, M., Enjoji, M., Irie, T., Sugimoto, R., Muta, T., Iwamoto, H., Nawata, H. Hepatology (2001)
- Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro. Balligand, J.L., Ungureanu-Longrois, D., Simmons, W.W., Pimental, D., Malinski, T.A., Kapturczak, M., Taha, Z., Lowenstein, C.J., Davidoff, A.J., Kelly, R.A. J. Biol. Chem. (1994)
- Inducible and endothelial nitric oxide synthase expression during development of transplant arteriosclerosis in rat aortic grafts. Akyürek, L.M., Fellström, B.C., Yan, Z.Q., Hansson, G.K., Funa, K., Larsson, E. Am. J. Pathol. (1996)
- Interleukin-1beta regulation of inducible nitric oxide synthase and cyclooxygenase-2 involves the p42/44 and p38 MAPK signaling pathways in cardiac myocytes. LaPointe, M.C., Isenović, E. Hypertension (1999)