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Gene Review

Yy1  -  YY1 transcription factor

Rattus norvegicus

Synonyms: NF-E1, NMP-1, NMP1, UCRBP
 
 
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Disease relevance of Yy1

 

High impact information on Yy1

  • Because of strong synteny between rat chromosome 6q32 and human 14q32, Yy1 may be also of interest in human type 1 diabetics showing significant linkage to markers on chromosome 14q32 [1].
  • Cysteamine increased HIF-1alpha expression, its binding to DNA, and enhanced the HIF-1alpha interactions with Egr-1 and other transcription factors (e.g., AP-1, AP-2, L-III BP, NF-E1, NF-E2, STAT4, and MRE), their binding to DNA [2].
  • Between well- and poorly compensated rats, significant differences on expression level were found for Yy1 (liver), Ppargamma (heart), Nfkappab (bone), Pref-1 (spleen), and Lepr (thymus, liver, heart) [3].

References

 
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