Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Plcb4 - phospholipase C, beta 4

Rattus norvegicus

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4, Beta4aa, PLC-beta-4, Phosphoinositide phospholipase C-beta-4, Phospholipase C-beta-4, ...

Haley, J.E. et al., Min, D.S. et al., Tanaka, O. et al., Di Salvo, J. et al., Adamski, F.M. et al., et al.

Adamski, Timms, Shieh, Di Salvo, Raatz Nelson,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Plcb4

Antisense constructs, consisting of the cytomegalovirus promoter driving antisense cRNA corresponding to the 3'-untranslated regions of PLC-beta1 and PLC-beta4, were injected into the nucleus of dissociated SCG neurons [1].

High impact information on Plcb4

To investigate functional differences between the two forms of PLC-beta4, transient expression studies in COS-7 cells were conducted [2].
However, neither PLC beta-1 nor PLC beta-4 was detected [3].
Immunological characterization of 130 kDa phospholipase C-beta 4 isozyme in rat cerebellar Purkinje cells [4].
Tissue distribution of 130 kDa PLC-beta4 was determined with this monoclonal antibody [4].
One hundred and thirty kiloDalton PLC-beta4 was exclusively expressed in the nervous tissues including cerebellum and cerebrum, especially at very high levels in cerebellum [4].

Biological context of Plcb4

The different carboxyl terminal tails of PLCbeta4 isoforms may allow for differential targeting and subcellular localization, contributing to regulation of PLC beta4-mediated signal transduction [5].
BK inhibition of I(K(M)) was significantly reduced 48 hr after injection of the PLC-beta4, but not the PLC-beta1, antisense-encoding plasmid [1].

Anatomical context of Plcb4

Only PLC-beta4 was not detected, whereas PLC-beta1, beta2 and beta3 were abundant in rat liver membranes [6].
Bradykinin, but not muscarinic, inhibition of M-current in rat sympathetic ganglion neurons involves phospholipase C-beta 4 [1].
In mature rat brain, PLC beta 3 mRNA was detected weakly only in the pituitary gland and the cerebellar Purkinje and granule cells whereas PLC beta 4 mRNA was expressed intensely in the olfactory mitral cells, thalamic nuclei, medial habenula, pituitary gland and cerebellar Purkinje and granule cells [7].
Endothelin inhibits the calcium pump and stimulates phosphoinositide phospholipase C in liver plasma membranes via two different G proteins, Gs and Gq [8].

Other interactions of Plcb4

On the other hand, PLC-beta 4, PLC-gamma 1 and PLC-gamma 2 were distributed almost equally among the regions for the rats of both ages [9].

Analytical, diagnostic and therapeutic context of Plcb4

Purification, molecular cloning, and sequencing of phospholipase C-beta 4 [10].

References

Bradykinin, but not muscarinic, inhibition of M-current in rat sympathetic ganglion neurons involves phospholipase C-beta 4. Haley, J.E., Abogadie, F.C., Fernandez-Fernandez, J.M., Dayrell, M., Vallis, Y., Buckley, N.J., Brown, D.A. J. Neurosci. (2000) [Pubmed]
A cytosolic, galphaq- and betagamma-insensitive splice variant of phospholipase C-beta4. Kim, M.J., Min, D.S., Ryu, S.H., Suh, P.G. J. Biol. Chem. (1998) [Pubmed]
Stimulation of G-protein coupled receptors in vascular smooth muscle cells induces tyrosine kinase dependent increases in calcium without tyrosine phosphorylation of phospholipase C gamma-1. Di Salvo, J., Raatz Nelson, S. FEBS Lett. (1998) [Pubmed]
Immunological characterization of 130 kDa phospholipase C-beta 4 isozyme in rat cerebellar Purkinje cells. Min, D.S., Kim, M.J., Jeong, H.K., Lee, Y.H., Kim, H., Shin, H.S., Ryu, S.H., Suh, P.G. Neurosci. Lett. (2000) [Pubmed]
A unique isoform of phospholipase Cbeta4 highly expressed in the cerebellum and eye. Adamski, F.M., Timms, K.M., Shieh, B.H. Biochim. Biophys. Acta (1999) [Pubmed]
Pancreastatin activates beta3 isoform of phospholipase C via G(alpha)11 protein stimulation in rat liver membranes. Santos-Alvarez, J., Sánchez-Margalet, V. Mol. Cell. Endocrinol. (1998) [Pubmed]
Localization of mRNAs for three novel members (beta 3, beta 4 and gamma 2) of phospholipase C family in mature rat brain. Tanaka, O., Kondo, H. Neurosci. Lett. (1994) [Pubmed]
Endothelin inhibits the calcium pump and stimulates phosphoinositide phospholipase C in liver plasma membranes via two different G proteins, Gs and Gq. Jouneaux, C., Goldsmith, P., Hanoune, J., Lotersztajn, S. J. Cardiovasc. Pharmacol. (1993) [Pubmed]
Attenuation of renomedullary phospholipase C isozyme, PLC-delta 1, in spontaneously hypertensive rats. Lee, K.H., Cho, Y.J., Cha, S.H., Endou, H. Biochem. Mol. Biol. Int. (1997) [Pubmed]
Purification, molecular cloning, and sequencing of phospholipase C-beta 4. Lee, C.W., Park, D.J., Lee, K.H., Kim, C.G., Rhee, S.G. J. Biol. Chem. (1993) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use

[search][advanced]

Editor

Personal info

View

About

Terms

AgaP_AGAP001936	Anopheles gambiae str. PEST
PLCB4	Bos taurus
egl-8	Caenorhabditis elegans
PLCB4	Canis lupus familiaris
LOC100537538	Danio rerio
norpA	Drosophila melanogaster
PLCB4	Gallus gallus
PLCB4	Homo sapiens
PLCB4	Macaca mulatta
Plcb4	Mus musculus
PLCB4	Pan troglodytes