Gene Review:
Stat3 - signal transducer and activator of...
Rattus norvegicus
Synonyms:
Signal transducer and activator of transcription 3
- Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements. Ripperger, J.A., Fritz, S., Richter, K., Hocke, G.M., Lottspeich, F., Fey, G.H. J. Biol. Chem. (1995)
- Stat3 activation in acute lung injury. Gao, H., Guo, R.F., Speyer, C.L., Reuben, J., Neff, T.A., Hoesel, L.M., Riedemann, N.C., McClintock, S.D., Sarma, J.V., Van Rooijen, N., Zetoune, F.S., Ward, P.A. J. Immunol. (2004)
- Suppression of Stat3 promotes neurogenesis in cultured neural stem cells. Gu, F., Hata, R., Ma, Y.J., Tanaka, J., Mitsuda, N., Kumon, Y., Hanakawa, Y., Hashimoto, K., Nakajima, K., Sakanaka, M. J. Neurosci. Res. (2005)
- Activation of signal transducer and activator of transcription-3 (Stat3) expression by interferon-gamma and interleukin-6 in hepatoma cells. Kordula, T., Bugno, M., Goldstein, J., Travis, J. Biochem. Biophys. Res. Commun. (1995)
- Activation of the JAK/STAT pathway following transient focal cerebral ischemia: signaling through Jak1 and Stat3 in astrocytes. Justicia, C., Gabriel, C., Planas, A.M. Glia (2000)
- Acute-phase response factor, increased binding, and target gene transcription during liver regeneration. Trautwein, C., Rakemann, T., Niehof, M., Rose-John, S., Manns, M.P. Gastroenterology (1996)
- GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction. Lufei, C., Ma, J., Huang, G., Zhang, T., Novotny-Diermayr, V., Ong, C.T., Cao, X. EMBO J. (2003)
- Role of the JAK/STAT pathway in rat carotid artery remodeling after vascular injury. Seki, Y., Kai, H., Shibata, R., Nagata, T., Yasukawa, H., Yoshimura, A., Imaizumi, T. Circ. Res. (2000)
- c-PKC-dependent modulation of plasma fibrinogen levels during the acute-phase response in young and old rats. La Porta, C.A., Franchi, C., Comolli, R. Mech. Ageing Dev. (1998)
- Role of oxidative stress in the increased activation of signal transducers and activators of transcription-3 in the fatty livers of obese Zucker rats. Dikdan, G.S., Saba, S.C., Dela Torre, A.N., Roth, J., Wang, S., Koneru, B. Surgery (2004)
- Rapid activation of the Stat3 transcription complex in liver regeneration. Cressman, D.E., Diamond, R.H., Taub, R. Hepatology (1995)
- Activation of the Stat3 signaling pathway is required for differentiation by interleukin-6 in PC12-E2 cells. Wu, Y.Y., Bradshaw, R.A. J. Biol. Chem. (2000)
- Differentiation-dependent prolactin responsiveness and stat (signal transducers and activators of transcription) signaling in rat ovarian cells. Russell, D.L., Richards, J.S. Mol. Endocrinol. (1999)
- Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase. Kirken, R.A., Malabarba, M.G., Xu, J., DaSilva, L., Erwin, R.A., Liu, X., Hennighausen, L., Rui, H., Farrar, W.L. J. Biol. Chem. (1997)
- AG490 prevents cell death after exposure of rat astrocytes to hydrogen peroxide or proinflammatory cytokines: involvement of the Jak2/STAT pathway. Gorina, R., Petegnief, V., Chamorro, A., Planas, A.M. J. Neurochem. (2005)
- Angiotensin II activates Stat5 through Jak2 kinase in cardiac myocytes. McWhinney, C.D., Dostal, D., Baker, K. J. Mol. Cell. Cardiol. (1998)
- The vagus nerve mediates behavioural depression, but not fever, in response to peripheral immune signals; a functional anatomical analysis. Konsman, J.P., Luheshi, G.N., Bluthé, R.M., Dantzer, R. Eur. J. Neurosci. (2000)
- Interleukin-10 receptor signaling through STAT-3 regulates the apoptosis of retinal ganglion cells in response to stress. Boyd, Z.S., Kriatchko, A., Yang, J., Agarwal, N., Wax, M.B., Patil, R.V. Invest. Ophthalmol. Vis. Sci. (2003)
- Transcriptional activation of the IL-6 response element in the junB promoter is mediated by multiple Stat family proteins. Fujitani, Y., Nakajima, K., Kojima, H., Nakae, K., Takeda, T., Hirano, T. Biochem. Biophys. Res. Commun. (1994)
- Isolation of two interleukin-6 response element binding proteins from acute phase rat livers. Ripperger, J., Fritz, S., Richter, K., Dreier, B., Schneider, K., Löchner, K., Marschalek, R., Hocke, G., Lottspeich, F., Fey, G.H. Ann. N. Y. Acad. Sci. (1995)
- Reduced hepatic transcription factor activation and expression of IL-6 and ICAM-1 after hemorrhage by NO scavenging. Hierholzer, C., Billiar, T.R., Tweardy, D.J., Harbrecht, B. Archives of orthopaedic and trauma surgery. (2003)
- After portal branch ligation in rat, nuclear factor kappaB, interleukin-6, signal transducers and activators of transcription 3, c-fos, c-myc, and c-jun are similarly induced in the ligated and nonligated lobes. Stärkel, P., Horsmans, Y., Sempoux, C., De Saeger, C., Wary, J., Lause, P., Maiter, D., Lambotte, L. Hepatology (1999)
- In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3. Gronowski, A.M., Zhong, Z., Wen, Z., Thomas, M.J., Darnell, J.E., Rotwein, P. Mol. Endocrinol. (1995)
- Molecular and functional contractile sequelae of rat intestinal ischemia/reperfusion injury. Hierholzer, C., Kalff, J.C., Audolfsson, G., Billiar, T.R., Tweardy, D.J., Bauer, A.J. Transplantation (1999)
- Phosphorylation of signal transducer and activator of transcription-3 (Stat3) after focal cerebral ischemia in rats. Suzuki, S., Tanaka, K., Nogawa, S., Dembo, T., Kosakai, A., Fukuuchi, Y. Exp. Neurol. (2001)