Gene Review:
FUT1 - fucosyltransferase 1 (galactoside 2-alpha...
Homo sapiens
Synonyms:
Alpha(1,2)FT 1, Blood group H alpha 2-fucosyltransferase, Fucosyltransferase 1, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1, Galactoside 2-alpha-L-fucosyltransferase 1, ...
- Structure and expression of H-type GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase gene (FUT1). Two transcription start sites and alternative splicing generate several forms of FUT1 mRNA. Koda, Y., Soejima, M., Kimura, H. J. Biol. Chem. (1997)
- Increased tumorigenicity of rat colon carcinoma cells after alpha1,2-fucosyltransferase FTA anti-sense cDNA transfection. Hallouin, F., Goupille, C., Bureau, V., Meflah, K., Le Pendu, J. Int. J. Cancer (1999)
- Two alpha(1,2) fucosyltransferase genes on porcine chromosome 6q11 are closely linked to the blood group inhibitor (S) and Escherichia coli F18 receptor (ECF18R) loci. Meijerink, E., Fries, R., Vögeli, P., Masabanda, J., Wigger, G., Stricker, C., Neuenschwander, S., Bertschinger, H.U., Stranzinger, G. Mamm. Genome (1997)
- Changing transcription start sites in H-type alpha(1,2)fucosyltransferase gene (FUT1) during differentiation of the human erythroid lineage. Koda, Y., Soejima, M., Kimura, H. Eur. J. Biochem. (1998)
- Increased thermosensitivity of mouse colorectal carcinoma cells transfected with human FUT1 gene. Okamura, A., Yazawa, S., Morinaga, N., Asao, T., Kuwano, H. Cancer Lett. (2002)
- A cloned human DNA restriction fragment determines expression of a GDP-L-fucose: beta-D-galactoside 2-alpha-L-fucosyltransferase in transfected cells. Evidence for isolation and transfer of the human H blood group locus. Rajan, V.P., Larsen, R.D., Ajmera, S., Ernst, L.K., Lowe, J.B. J. Biol. Chem. (1989)
- The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter. Lühn, K., Wild, M.K., Eckhardt, M., Gerardy-Schahn, R., Vestweber, D. Nat. Genet. (2001)
- Expression cloning of a functional glycoprotein ligand for P-selectin. Sako, D., Chang, X.J., Barone, K.M., Vachino, G., White, H.M., Shaw, G., Veldman, G.M., Bean, K.M., Ahern, T.J., Furie, B. Cell (1993)
- ELAM-1--dependent cell adhesion to vascular endothelium determined by a transfected human fucosyltransferase cDNA. Lowe, J.B., Stoolman, L.M., Nair, R.P., Larsen, R.D., Berhend, T.L., Marks, R.M. Cell (1990)
- Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Fuhlbrigge, R.C., Kieffer, J.D., Armerding, D., Kupper, T.S. Nature (1997)
- Expression of alpha-1,3-fucosyltransferase type IV and VII genes is related to poor prognosis in lung cancer. Ogawa, J., Inoue, H., Koide, S. Cancer Res. (1996)
- Restoration of alpha(1,2) fucosyltransferase activity decreases adhesive and metastatic properties of human pancreatic cancer cells. Aubert, M., Panicot, L., Crotte, C., Gibier, P., Lombardo, D., Sadoulet, M.O., Mas, E. Cancer Res. (2000)
- Ito cells are liver-resident antigen-presenting cells for activating T cell responses. Winau, F., Hegasy, G., Weiskirchen, R., Weber, S., Cassan, C., Sieling, P.A., Modlin, R.L., Liblau, R.S., Gressner, A.M., Kaufmann, S.H. Immunity (2007)
- Guanosine diphosphate-L-fucose plasma: N-acetylglucosaminide fucosyltransferase as in index of bone marrow hyperplasia after chemotherapy. Khilanani, P., Chou, T.H., Kessel, D. Cancer Res. (1978)
- Pirfenidone effectively reverses experimental liver fibrosis. García, L., Hernández, I., Sandoval, A., Salazar, A., Garcia, J., Vera, J., Grijalva, G., Muriel, P., Margolin, S., Armendariz-Borunda, J. J. Hepatol. (2002)
- Molecular cloning of a human genomic region containing the H blood group alpha(1,2)fucosyltransferase gene and two H locus-related DNA restriction fragments. Isolation of a candidate for the human Secretor blood group locus. Rouquier, S., Lowe, J.B., Kelly, R.J., Fertitta, A.L., Lennon, G.G., Giorgi, D. J. Biol. Chem. (1995)
- A new h allele detected in Europe has a missense mutationin alpha(1,2)-fucosyltransferase motif II. Wagner, T., Vadon, M., Staudacher, E., Schmarda, A., Gassner, C., Helmberg, W., Lanzer, G., Flegel, W.A., Wagner, F.F. Transfusion (2001)
- The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9. Ball, S.P., Tongue, N., Gibaud, A., Le Pendu, J., Mollicone, R., Gérard, G., Oriol, R. Ann. Hum. Genet. (1991)
- Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19. Reguigne-Arnould, I., Couillin, P., Mollicone, R., Fauré, S., Fletcher, A., Kelly, R.J., Lowe, J.B., Oriol, R. Cytogenet. Cell Genet. (1995)
- Expression of human alpha-l-fucosyltransferase gene homologs in monkey kidney COS cells and modification of potential fucosyltransferase acceptor substrates by an endogenous glycosidase. Clarke, J.L., Watkins, W.M. Glycobiology (1999)
- Molecular genetics of H, Se, Lewis and other fucosyltransferase genes. Mollicone, R., Cailleau, A., Oriol, R. Transfusion clinique et biologique : journal de la Société française de transfusion sanguine. (1995)
- Fucosyltransferase activities in human pancreatic tissue: comparative study between cancer tissues and established tumoral cell lines. Mas, E., Pasqualini, E., Caillol, N., El Battari, A., Crotte, C., Lombardo, D., Sadoulet, M.O. Glycobiology (1998)
- Molecular genetics of alpha-L-fucosyltransferase genes (H, Se, Le, FUT4, FUT5 and FUT6). Mollicone, R., Candelier, J.J., Reguigne, I., Couillin, P., Fletcher, A., Oriol, R. Transfusion clinique et biologique : journal de la Société française de transfusion sanguine. (1994)
- Deficiency of reproductive tract alpha(1,2)fucosylated glycans and normal fertility in mice with targeted deletions of the FUT1 or FUT2 alpha(1,2)fucosyltransferase locus. Domino, S.E., Zhang, L., Gillespie, P.J., Saunders, T.L., Lowe, J.B. Mol. Cell. Biol. (2001)
- Comparison of the three rat GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferases FTA, FTB and FTC. Bureau, V., Marionneau, S., Cailleau-Thomas, A., Le Moullac-Vaidye, B., Liehr, T., Le Pendu, J. Eur. J. Biochem. (2001)
- A missense mutation in the FUT6 gene results in total absence of alpha3-fucosylation of human alpha1-acid glycoprotein. Brinkman-Van der Linden, E.C., Mollicone, R., Oriol, R., Larson, G., Van den Eijnden, D.H., Van Dijk, W. J. Biol. Chem. (1996)
- Characterization of the specificities of human blood group H gene-specified alpha 1,2-L-fucosyltransferase toward sulfated/sialylated/fucosylated acceptors: evidence for an inverse relationship between alpha 1,2-L-fucosylation of Gal and alpha 1,6-L-fucosylation of asparagine-linked GlcNAc. Chandrasekaran, E.V., Jain, R.K., Larsen, R.D., Wlasichuk, K., Matta, K.L. Biochemistry (1996)
- CEACAM1, an adhesion molecule of human granulocytes, is fucosylated by fucosyltransferase IX and interacts with DC-SIGN of dendritic cells via Lewis x residues. Bogoevska, V., Horst, A., Klampe, B., Lucka, L., Wagener, C., Nollau, P. Glycobiology (2006)
- Molecular basis of leukocyte rolling on PSGL-1. Predominant role of core-2 O-glycans and of tyrosine sulfate residue 51. Bernimoulin, M.P., Zeng, X.L., Abbal, C., Giraud, S., Martinez, M., Michielin, O., Schapira, M., Spertini, O. J. Biol. Chem. (2003)
- The fucosyltransferase FucT-VII regulates E-selectin ligand synthesis in human T cells. Knibbs, R.N., Craig, R.A., Natsuka, S., Chang, A., Cameron, M., Lowe, J.B., Stoolman, L.M. J. Cell Biol. (1996)
- Advances in molecular genetics of alpha-2- and alpha-3/4-fucosyltransferases. Costache, M., Cailleau, A., Fernandez-Mateos, P., Oriol, R., Mollicone, R. Transfusion clinique et biologique : journal de la Société française de transfusion sanguine. (1997)
- Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system. Koda, Y., Soejima, M., Johnson, P.H., Smart, E., Kimura, H. Biochem. Biophys. Res. Commun. (1997)
- Molecular cloning, chromosomal assignment and tissue-specific expression of a murine alpha(1,2)fucosyltransferase expressed in thymic and epididymal epithelial cells. Domino, S.E., Hiraiwa, N., Lowe, J.B. Biochem. J. (1997)
- Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen. Larsen, R.D., Ernst, L.K., Nair, R.P., Lowe, J.B. Proc. Natl. Acad. Sci. U.S.A. (1990)