Gene Review:
Tshr - thyroid stimulating hormone receptor
Rattus norvegicus
Synonyms:
TSH-R, Thyroid-stimulating hormone receptor, Thyrotropin receptor
- Mutation of alanine 623 in the third cytoplasmic loop of the rat thyrotropin (TSH) receptor results in a loss in the phosphoinositide but not cAMP signal induced by TSH and receptor autoantibodies. Kosugi, S., Okajima, F., Ban, T., Hidaka, A., Shenker, A., Kohn, L.D. J. Biol. Chem. (1992)
- Mutations of thyrotropin receptor isolated from thyroid autonomous functioning adenomas confer TSH-independent growth to thyroid cells. Porcellini, A., Ruggiano, G., Pannain, S., Ciullo, I., Amabile, G., Fenzi, G., Avvedimento, E.V. Oncogene (1997)
- p66Shc expression in proliferating thyroid cells is regulated by thyrotropin receptor signaling. Park, Y.J., Kim, T.Y., Lee, S.H., Kim, H., Kim, S.W., Shong, M., Yoon, Y.K., Cho, B.Y., Park, D.J. Endocrinology (2005)
- Somatic mutations of the thyroid-stimulating hormone receptor gene in feline hyperthyroidism: parallels with human hyperthyroidism. Watson, S.G., Radford, A.D., Kipar, A., Ibarrola, P., Blackwood, L. J. Endocrinol. (2005)
- Effect of neonatal treatment with monoclonal antibody to thyrotropin (TSH) receptor on the thyroxin (T4) level and certain parameters of the internal genital organs of adult rats. Karabélyos, C., Nagy, S.U., Csaba, G. Acta physiologica Hungarica. (1996)
- Thyroid-stimulating hormone (TSH)-directed induction of the CREM gene in the thyroid gland participates in the long-term desensitization of the TSH receptor. Lalli, E., Sassone-Corsi, P. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Cloning, chromosomal assignment, and regulation of the rat thyrotropin receptor: expression of the gene is regulated by thyrotropin, agents that increase cAMP levels, and thyroid autoantibodies. Akamizu, T., Ikuyama, S., Saji, M., Kosugi, S., Kozak, C., McBride, O.W., Kohn, L.D. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Reevaluation of the role of gangliosides in the binding and action of thyrotropin. Beckner, S.K., Brady, R.O., Fishman, P.H. Proc. Natl. Acad. Sci. U.S.A. (1981)
- Cloning and functional expression of a thyrotropin receptor cDNA from rat fat cells. Endo, T., Ohta, K., Haraguchi, K., Onaya, T. J. Biol. Chem. (1995)
- Derivation of functional antagonists using N-terminal extracellular domain of gonadotropin and thyrotropin receptors. Osuga, Y., Kudo, M., Kaipia, A., Kobilka, B., Hsueh, A.J. Mol. Endocrinol. (1997)
- Cloning of the single strand DNA-binding protein important for maximal expression and thyrotropin (TSH)-induced negative regulation of the TSH receptor. Ohmori, M., Ohta, M., Shimura, H., Shimurat, Y., Suzuki, K., Kohn, L.D. Mol. Endocrinol. (1996)
- GRK2 and beta-arrestin 1 as negative regulators of thyrotropin receptor-stimulated response. Iacovelli, L., Franchetti, R., Masini, M., De Blasi, A. Mol. Endocrinol. (1996)
- Major histocompatibility complex class I gene expression in rat thyroid cells is regulated by hormones, methimazole, and iodide as well as interferon. Saji, M., Moriarty, J., Ban, T., Singer, D.S., Kohn, L.D. J. Clin. Endocrinol. Metab. (1992)
- Biological activity of activating thyrotrophin receptor mutants: modulation by iodide. Al-Khafaji, F., Wiltshire, M., Fuhrer, D., Mazziotti, G., Lewis, M.D., Smith, P.J., Ludgate, M. J. Mol. Endocrinol. (2005)
- Epitopes for thyroid stimulating and blocking autoantibodies on the extracellular domain of the human thyrotropin receptor. Tahara, K., Ishikawa, N., Yamamoto, K., Hirai, A., Ito, K., Tamura, Y., Yoshida, S., Saito, Y., Kohn, L.D. Thyroid (1997)
- Insight into thyrotropin receptor cleavage by engineering the single polypeptide chain luteinizing hormone receptor into a cleaving, two subunit receptor. Chazenbalk, G.D., McLachlan, S.M., Chen, C.R., Rapoport, B. Eur. J. Biochem. (2001)
- Synthesis of (bis)sulfonic acid, (bis)benzamides as follicle-stimulating hormone (FSH) antagonists. Wrobel, J., Green, D., Jetter, J., Kao, W., Rogers, J., Pérez, M.C., Hardenburg, J., Deecher, D.C., López, F.J., Arey, B.J., Shen, E.S. Bioorg. Med. Chem. (2002)
- The basolateral sorting signals of the thyrotropin and luteinizing hormone receptors: an unusual family of signals sharing an unusual distal intracellular localization, but unrelated in their structures. Beau, I., Groyer-Picard, M.T., Desroches, A., Condamine, E., Leprince, J., Tomé, J.P., Dessen, P., Vaudry, H., Misrahi, M. Mol. Endocrinol. (2004)
- TPA induces a block of differentiation and increases the susceptibility to neoplastic transformation of a rat thyroid epithelial cell line. Portella, G., Vitagliano, D., Li, Z., Sferratore, F., Santoro, M., Vecchio, G., Fusco, A. Oncol. Res. (1998)
- Insulin-like growth factor-I stimulates the growth of rat thyroid cells in culture and synergizes the stimulation of DNA synthesis induced by TSH and Graves'-IgG. Tramontano, D., Cushing, G.W., Moses, A.C., Ingbar, S.H. Endocrinology (1986)
- Regulation of thyrotropin receptor gene expression in rat FRTL-5 thyroid cells. Saji, M., Akamizu, T., Sanchez, M., Obici, S., Avvedimento, E., Gottesman, M.E., Kohn, L.D. Endocrinology (1992)
- 1,25-Dihydroxyvitamin D3 attenuates adenylyl cyclase activity in rat thyroid cells: reduction of thyrotropin receptor number and increase in guanine nucleotide-binding protein Gi-2 alpha. Berg, J.P., Sandvik, J.A., Ree, A.H., Sørnes, G., Bjøro, T., Torjesen, P.A., Gordeladze, J.O., Haug, E. Endocrinology (1994)
- The formation of thyrotropin receptor (TSHR) antibodies in a Graves' animal model requires the N-terminal segment of the TSHR extracellular domain. Kikuoka, S., Shimojo, N., Yamaguchi, K.I., Watanabe, Y., Hoshioka, A., Hirai, A., Saito, Y., Tahara, K., Kohn, L.D., Maruyama, N., Kohno, Y., Niimi, H. Endocrinology (1998)
- Identification of separate determinants on the thyrotropin receptor reactive with Graves' thyroid-stimulating antibodies and with thyroid-stimulating blocking antibodies in idiopathic myxedema: these determinants have no homologous sequence on gonadotropin receptors. Kosugi, S., Ban, T., Akamizu, T., Kohn, L.D. Mol. Endocrinol. (1992)
- Regulation of the rat thyrotropin receptor gene by the methylation-sensitive transcription factor GA-binding protein. Yokomori, N., Tawata, M., Saito, T., Shimura, H., Onaya, T. Mol. Endocrinol. (1998)
- Recombinant human thyrotropin (TSH) receptor in a radioreceptor assay for the measurement of TSH receptor autoantibodies. Filetti, S., Foti, D., Costante, G., Rapoport, B. J. Clin. Endocrinol. Metab. (1991)