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Gene Review: 

ef1a-c  -  translation elongation factor EF-1 alpha...

Schizosaccharomyces pombe 972h-

 
 
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Disease relevance of ef1-b

  • While the purified yeast EF-1 alpha s function analogously to other eukaryotic factors and the E. coli EF-Tu in Phe-tRNA binding and polyphenylalanine synthesis, the yeast factor unusually hydrolyzed GTP on yeast ribosomes upon addition of Phe-tRNA in the absence of poly(U) as mRNA [1].
 

High impact information on ef1-b

  • Based on sequence homology, the genes were identified as TEF, encoding translation elongation factor-1 alpha and RPS7, encoding ribosomal protein S7 [2].
  • Expression of full-length EF1alpha in vivo caused an increase in cell cycle length and a decreased rate of growth as evidenced by a lack of elongated cells in slowly dividing cultures [3].
  • The predicted protein is highly homologous to mammalian EF1alpha, indicating a strong tendency towards conservation of the primary amino acid sequence [3].

References

  1. Peptide elongation factor 1 from yeasts: purification and biochemical characterization of peptide elongation factors 1 alpha and 1 beta (gamma) from Saccharomyces carlsbergensis and Schizosaccharomyces pombe. Miyazaki, M., Uritani, M., Fujimura, K., Yamakatsu, H., Kageyama, T., Takahashi, K. J. Biochem. (1988) [Pubmed]
  2. Comparison of expression systems in the yeasts Saccharomyces cerevisiae, Hansenula polymorpha, Klyveromyces lactis, Schizosaccharomyces pombe and Yarrowia lipolytica. Cloning of two novel promoters from Yarrowia lipolytica. Müller, S., Sandal, T., Kamp-Hansen, P., Dalbøge, H. Yeast (1998) [Pubmed]
  3. Cloning of a Schizosaccharomyces pombe homologue of elongation factor 1 alpha by two-hybrid selection of calmodulin-binding proteins. Rasmussen, C., Wiebe, C. Biochem. Cell Biol. (1999) [Pubmed]
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