Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

swi6 - chromodomain protein Swi6

Schizosaccharomyces pombe 972h-

Wang, G. et al., Klar, A.J. et al., Lorentz, A. et al.

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High impact information on swi6

In the yeast, Schizosaccharomyces pombe, the swi6 gene encodes a heterochromatin protein 1 (HP1)-like chromodomain protein that localizes to heterochromatin domains, including the centromeres, telomeres, and the donor mating-type loci, and is involved in silencing at these loci [1].
By testing for meiotic recombination in the cold spot, we found the usual lack of recombination in a swi2 mutant but a significant level of recombination in a swi6 mutant [2].
swi6, a gene required for mating-type switching, prohibits meiotic recombination in the mat2-mat3 "cold spot" of fission yeast [2].
Furthermore, swi6 allows meiotic recombination in the K region, a region of 16 kb between mat2:2 and mat3:3; in wild-type strains no recombination occurs in K. swi6 also allows the simultaneous expression of two different cassettes in the same haploid cell [3].

Analytical, diagnostic and therapeutic context of swi6

Site-directed mutagenesis, based on a modeled three-dimensional structure of the swi6p chromodomain, shows that the hydrophobic amino acids which lie in the core of the structure are critical for biological function [1].

References

Conservation of heterochromatin protein 1 function. Wang, G., Ma, A., Chow, C.M., Horsley, D., Brown, N.R., Cowell, I.G., Singh, P.B. Mol. Cell. Biol. (2000) [Pubmed]
swi6, a gene required for mating-type switching, prohibits meiotic recombination in the mat2-mat3 "cold spot" of fission yeast. Klar, A.J., Bonaduce, M.J. Genetics (1991) [Pubmed]
The switching gene swi6 affects recombination and gene expression in the mating-type region of Schizosaccharomyces pombe. Lorentz, A., Heim, L., Schmidt, H. Mol. Gen. Genet. (1992) [Pubmed]

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