Gene Review:
XRCC6 - X-ray repair complementing defective...
Homo sapiens
Synonyms:
5'-dRP lyase Ku70, 5'-deoxyribose-5-phosphate lyase Ku70, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70 kDa subunit, ...
Yagura,
Sumi,
Kelavkar,
Wang,
Badr,
Brown,
Lataxes,
Shangary,
Mannino,
Giardina,
Chen,
Baskaran,
Munshi,
Tanaka,
Hobbs,
Tucker,
Richon,
Meyn,
Raju,
Ariga,
Dittmann,
Nakata,
Ang,
Milas,
Bentley,
Diggle,
Harnden,
Knowles,
Kiltie,
Beskow,
Kanter,
Holgersson,
Nilsson,
Frankendal,
Avall-Lundqvist,
Lewensohn,
Grote,
K??nig,
Ackermann,
Sopalla,
Benedyk,
Los,
Kerkhoff,
- Expression of Ku70 and Ku80 mediated by NF-kappa B and cyclooxygenase-2 is related to proliferation of human gastric cancer cells. Lim, J.W., Kim, H., Kim, K.H. J. Biol. Chem. (2002)
- Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1. Li, B., Navarro, S., Kasahara, N., Comai, L. J. Biol. Chem. (2004)
- Isolation of Ku70-binding proteins (KUBs). Yang, C.R., Yeh, S., Leskov, K., Odegaard, E., Hsu, H.L., Chang, C., Kinsella, T.J., Chen, D.J., Boothman, D.A. Nucleic Acids Res. (1999)
- Expression and heterodimer-binding activity of Ku70 and Ku80 in human non-melanoma skin cancer. Parrella, P., Mazzarelli, P., Signori, E., Perrone, G., Marangi, G.F., Rabitti, C., Delfino, M., Prencipe, M., Gallo, A.P., Rinaldi, M., Fabbrocini, G., Delfino, S., Persichetti, P., Fazio, V.M. J. Clin. Pathol. (2006)
- Ku70, a component of DNA-dependent protein kinase, is a mammalian receptor for Rickettsia conorii. Martinez, J.J., Seveau, S., Veiga, E., Matsuyama, S., Cossart, P. Cell (2005)
- Cerebral blood flow in normal and abnormal sleep and dreaming. Meyer, J.S., Ishikawa, Y., Hata, T., Karacan, I. Brain and cognition. (1987)
- Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis. Goedecke, W., Eijpe, M., Offenberg, H.H., van Aalderen, M., Heyting, C. Nat. Genet. (1999)
- Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Walker, J.R., Corpina, R.A., Goldberg, J. Nature (2001)
- Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells. Mayeur, G.L., Kung, W.J., Martinez, A., Izumiya, C., Chen, D.J., Kung, H.J. J. Biol. Chem. (2005)
- Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their down-regulation potentiates it. Rashmi, R., Kumar, S., Karunagaran, D. Carcinogenesis (2004)
- Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen. Genersch, E., Eckerskorn, C., Lottspeich, F., Herzog, C., Kühn, K., Pöschl, E. EMBO J. (1995)
- Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death. Yang, C.R., Leskov, K., Hosley-Eberlein, K., Criswell, T., Pink, J.J., Kinsella, T.J., Boothman, D.A. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Ku autoantigen affects the susceptibility to anticancer drugs. Kim, S.H., Kim, D., Han, J.S., Jeong, C.S., Chung, B.S., Kang, C.D., Li, G.C. Cancer Res. (1999)
- Adenovirus-mediated expression of a dominant negative Ku70 fragment radiosensitizes human tumor cells under aerobic and hypoxic conditions. He, F., Li, L., Kim, D., Wen, B., Deng, X., Gutin, P.H., Ling, C.C., Li, G.C. Cancer Res. (2007)
- Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions. Jin, S., Weaver, D.T. EMBO J. (1997)
- The Ku protein complex interacts with YY1, is up-regulated in human heart failure, and represses alpha myosin heavy-chain gene expression. Sucharov, C.C., Helmke, S.M., Langer, S.J., Perryman, M.B., Bristow, M., Leinwand, L. Mol. Cell. Biol. (2004)
- Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements. Schaffer, A., Kim, E.C., Wu, X., Zan, H., Testoni, L., Salamon, S., Cerutti, A., Casali, P. J. Biol. Chem. (2003)
- Expression of DNA damage response proteins and complete remission after radiotherapy of stage IB-IIA of cervical cancer. Beskow, C., Kanter, L., Holgersson, A., Nilsson, B., Frankendal, B., Avall-Lundqvist, E., Lewensohn, R. Br. J. Cancer (2006)
- DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer. Chan, D.W., Ye, R., Veillette, C.J., Lees-Miller, S.P. Biochemistry (1999)
- Inhibition of DNA repair as a mechanism of enhanced radioresponse of head and neck carcinoma cells by a selective cyclooxygenase-2 inhibitor, celecoxib. Raju, U., Ariga, H., Dittmann, K., Nakata, E., Ang, K.K., Milas, L. Int. J. Radiat. Oncol. Biol. Phys. (2005)
- Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci. Munshi, A., Tanaka, T., Hobbs, M.L., Tucker, S.L., Richon, V.M., Meyn, R.E. Mol. Cancer Ther. (2006)
- p95vav associates with the nuclear protein Ku-70. Romero, F., Dargemont, C., Pozo, F., Reeves, W.H., Camonis, J., Gisselbrecht, S., Fischer, S. Mol. Cell. Biol. (1996)
- Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex. Li, B., Comai, L. J. Biol. Chem. (2001)
- Human Ku70 interacts with heterochromatin protein 1alpha. Song, K., Jung, Y., Jung, D., Lee, I. J. Biol. Chem. (2001)
- The Ku70 autoantigen interacts with p40phox in B lymphocytes. Grandvaux, N., Grizot, S., Vignais, P.V., Dagher, M.C. J. Cell. Sci. (1999)
- Repression of the HSP70B promoter by NFIL6, Ku70, and MAPK involves three complementary mechanisms. Tang, D., Xie, Y., Zhao, M., Stevenson, M.A., Calderwood, S.K. Biochem. Biophys. Res. Commun. (2001)
- Identification of poly(ADP-ribose)polymerase-1 and Ku70/Ku80 as transcriptional regulators of S100A9 gene expression. Grote, J., K??nig, S., Ackermann, D., Sopalla, C., Benedyk, M., Los, M., Kerkhoff, C. BMC Mol. Biol. (2006)
- Interaction of human Ku70 with TRF2. Song, K., Jung, D., Jung, Y., Lee, S.G., Lee, I. FEBS Lett. (2000)
- Ku autoantigen (DNA helicase) is required for interleukins-13/-4-induction of 15-lipoxygenase-1 gene expression in human epithelial cells. Kelavkar, U.P., Wang, S., Badr, K.F. Genes Immun. (2000)
- DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining. Bentley, J., Diggle, C.P., Harnden, P., Knowles, M.A., Kiltie, A.E. Nucleic Acids Res. (2004)
- Ku complex interacts with and stimulates the Werner protein. Cooper, M.P., Machwe, A., Orren, D.K., Brosh, R.M., Ramsden, D., Bohr, V.A. Genes Dev. (2000)
- Ionizing radiation exposure results in up-regulation of Ku70 via a p53/ataxia-telangiectasia-mutated protein-dependent mechanism. Brown, K.D., Lataxes, T.A., Shangary, S., Mannino, J.L., Giardina, J.F., Chen, J., Baskaran, R. J. Biol. Chem. (2000)
- Molecular cloning and sequencing of cDNAs encoding homologues of human Ku70 and Ku80 autoantigen from Xenopus and their expression in various Xenopus tissues. Yagura, T., Sumi, K. Biochim. Biophys. Acta (1999)