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Nog  -  noggin

Rattus norvegicus

Synonyms: Noggin
 
 
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Disease relevance of Nog

  • Noggin pretreatment reduced the protection induced by fetal kidney grafting, although noggin itself did not cause increase in cerebral infarction [1].
  • Syngeneic dermal fibroblasts (SDFs) were transduced ex vivo with adenoviruses encoding either green fluorescent protein (Ad-GFP or control virus), BMP-7 (Ad-BMP-7), or an antagonist of BMP bioactivity, noggin (Ad-noggin) [2].
 

High impact information on Nog

 

Biological context of Nog

  • BMPs and noggin, a specific binding protein that blocks BMP actions, are expressed by osteoblastic cells but there is limited information about regulation of BMP synthesis in skeletal cells [5].
  • Together, these results support the hypothesis that the BMPs and their antagonist noggin co-regulate cortical cell fate and morphogenesis [6].
  • Analysis by means of reverse transcription real-time PCR showed significant changes in abundance of five transcripts: gamma protein kinase C (PKC), upstream binding factor 2 (UBF2), lysozyme, noggin and heat shock protein 70 (hsp70) [7].
 

Anatomical context of Nog

  • BMP ligands and receptors, as well as the BMP antagonist noggin, are expressed in the developing cerebral cortex, making the BMPs likely candidates for regulating cortical development [6].
  • Results demonstrate that noggin expression does not antagonize terminal astroglial differentiation in the engrafted stem cells [8].
  • Consequences of noggin expression by neural stem, glial, and neuronal precursor cells engrafted into the injured spinal cord [8].
  • Furthermore, neutralizing endogenous BMP in the injured spinal cord significantly increased both the lesion volume and the number of infiltrating macrophages in injured spinal cords receiving noggin-expressing stem cell grafts compared with EGFP controls [8].
  • Interestingly, levels of BMP 7 and noggin, a BMP antagonist, were uniquely elevated in substantia nigra [9].
 

Other interactions of Nog

 

Analytical, diagnostic and therapeutic context of Nog

  • BMP-2 caused a time- and dose-dependent increase in noggin mRNA and polypeptide levels, as determined by Northern and Western blot analyses [3].
  • Animals receiving fetal kidney tissue transplantation developed significantly less body asymmetry, as compared to stroke animals that either did not receive transplantation or received fetal kidney grafts and noggin pretreatment [1].
  • Some animals were grafted with fetal kidney tissue after intraventricular administration (ICV) of the BMP antagonist noggin (1 micro g) or after vehicle, followed by MCA ligation for 60 min [1].
  • METHODS: Expression of noggin mRNA was measured by in situ hybridization method and the ability to spatial learning and memory was tested with Morris water maze [11].

References

  1. Bone morphogenetic proteins are involved in fetal kidney tissue transplantation-induced neuroprotection in stroke rats. Chang, C.F., Morales, M., Chou, J., Chen, H.L., Hoffer, B., Wang, Y. Neuropharmacology (2002) [Pubmed]
  2. Gene therapy of bone morphogenetic protein for periodontal tissue engineering. Jin, Q.M., Anusaksathien, O., Webb, S.A., Rutherford, R.B., Giannobile, W.V. J. Periodontol. (2003) [Pubmed]
  3. Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts. Gazzerro, E., Gangji, V., Canalis, E. J. Clin. Invest. (1998) [Pubmed]
  4. The bone morphogenetic proteins antagonist Noggin inhibits membranous ossification. Aspenberg, P., Jeppsson, C., Economides, A.N. J. Bone Miner. Res. (2001) [Pubmed]
  5. Bone morphogenetic protein-4 regulates its own expression in cultured osteoblasts. Pereira, R.C., Rydziel, S., Canalis, E. J. Cell. Physiol. (2000) [Pubmed]
  6. Multiple roles of bone morphogenetic protein signaling in the regulation of cortical cell number and phenotype. Mabie, P.C., Mehler, M.F., Kessler, J.A. J. Neurosci. (1999) [Pubmed]
  7. Effects of morphine on gene expression in the rat amygdala. Rodriguez Parkitna, J.M., Bilecki, W., Mierzejewski, P., Stefanski, R., Ligeza, A., Bargiela, A., Ziolkowska, B., Kostowski, W., Przewlocki, R. J. Neurochem. (2004) [Pubmed]
  8. Consequences of noggin expression by neural stem, glial, and neuronal precursor cells engrafted into the injured spinal cord. Enzmann, G.U., Benton, R.L., Woock, J.P., Howard, R.M., Tsoulfas, P., Whittemore, S.R. Exp. Neurol. (2005) [Pubmed]
  9. Expression of bone morphogenetic proteins in the brain during normal aging and in 6-hydroxydopamine-lesioned animals. Chen, H.L., Lein, P.J., Wang, J.Y., Gash, D., Hoffer, B.J., Chiang, Y.H. Brain Res. (2003) [Pubmed]
  10. Stem cell differentiation requires a paracrine pathway in the heart. Behfar, A., Zingman, L.V., Hodgson, D.M., Rauzier, J.M., Kane, G.C., Terzic, A., Pucéat, M. FASEB J. (2002) [Pubmed]
  11. Effect of antisense oligonucleotide of noggin on spatial learning and memory of rats. Fan, X.T., Cai, W.Q., Yang, Z., Xu, H.W., Zhang, J.H. Acta Pharmacol. Sin. (2003) [Pubmed]
 
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