The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

GABRA1  -  gamma-aminobutyric acid (GABA) A receptor,...

Homo sapiens

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of GABRA1

  • OBJECTIVE: The objective of this study was to investigate functional mutations or polymorphisms of the GABA-A receptor alpha1-subunit gene (GABRA1) in girls with idiopathic gonadotropin-dependent precocious puberty (GDPP) with and without electroencephalographic (EEG) abnormalities [1].
  • Purpose: Previous studies in neonatal (postnatal day 10) and adult rats suggest that status epilepticus (SE) induces changes in the alpha1 subunit of the GABA(A) receptor (GABRA1) in dentate granule neurons (DGNs) that are age dependent and vary inversely with the likelihood of epilepsy development [2].
  • Genetic analysis of the GABRA1 gene in patients with essential tremor [3].
  • Mutation screen of GABRA1, GABRB2 and GABRG2 genes in Japanese patients with absence seizures [4].
  • An Ala322Asp mutation in the GABRA1 gene was recently reported to be responsible for causing the autosomal dominant (AD) form of juvenile myoclonic epilepsy (JME) in a French-Canadian family [5].
 

Psychiatry related information on GABRA1

  • The possible association of GABRA1 with the psychopathology of major psychoses was tested both alone and in interaction with DRD4 [6].
  • DRD2, DRD4 and GABRA1 variants therefore do not appear to be associated with the outcome of lithium prophylaxis in mood disorders [7].
  • CONCLUSIONS: These results indicate that the GABRA1 gene may play a role in the etiology of bipolar disorders [8].
  • METHODS: We performed mutation screening of GABRA1 in 24 Japanese bipolar patients and evaluated associations in Japanese case-control subjects consisting of 125 patients with bipolar disorder, 147 patients with depressive disorders, and 191 healthy control subjects [8].
  • RESULTS: In GABRA1, we found evidence of association with several of the drinking behavior phenotypes, including COGA alcohol dependence, history of blackouts, age at first drunkenness, and level of response to alcohol [9].
 

High impact information on GABRA1

  • Our results confirm that mutation of GABRA1 predisposes towards a common idiopathic generalized epilepsy syndrome in humans [10].
  • We report that an Ala322Asp mutation in GABRA1, encoding the alpha1 subunit of the gamma-aminobutyric acid receptor subtype A (GABA(A)), is found in affected individuals of a large French Canadian family with juvenile myoclonic epilepsy [10].
  • Comparison of transcript levels in schizophrenia patients and unaffected siblings found lower patient expression of GABRA6 and coexpressed genes of GABRA1 [11].
  • The GABRA1 and GABRP findings were replicated in the second stage in an independent German family-based sample (P=0.0015-0.043) [11].
  • Interestingly, the GABRA1 coexpressed genes include synaptic and vesicle-associated genes previously found altered in schizophrenia prefrontal cortex [11].
 

Chemical compound and disease context of GABRA1

 

Biological context of GABRA1

 

Anatomical context of GABRA1

 

Associations of GABRA1 with chemical compounds

 

Regulatory relationships of GABRA1

  • GABRA1 variants did not significantly influence the association of DRD4 with delusional symptoms [6].
 

Other interactions of GABRA1

  • These results reveal the clustering of GABRA6, GABRA1, and the GABAA receptor gamma 2-subunit gene (GABRG2) on distal chromosome 5q [15].
  • The order of the GABR subunit genes with respect to known anonymous gene loci is cen-D5S380 - D5S403 - D5S529 - GABRB2 - GABRA1/A6 - GABRG2-D 5S422-tel [14].
 

Analytical, diagnostic and therapeutic context of GABRA1

  • Four hundred and sixty-one inpatients affected by major psychoses were assessed by the operational criteria checklist for psychotic illness (OPCRIT) and were also typed for the DRD4 and GABRA1 variants using PCR techniques [6].
  • CONCLUSIONS: GABRA1 functional mutations or polymorphisms are not associated with the intrinsic mechanism of GDPP in girls with and without EEG abnormalities [1].
  • GABRA1 mRNA and protein levels were determined 7 days or 3 months later in SE-exposed and control animals by using a combination of aRNA amplification, Western blotting, and immunohistochemistry techniques [2].

References

  1. Allelic variants of the gamma-aminobutyric acid-A receptor alpha1-subunit gene (GABRA1) are not associated with idiopathic gonadotropin-dependent precocious puberty in girls with and without electroencephalographic abnormalities. Brito, V.N., Mendonca, B.B., Guilhoto, L.M., Freitas, K.C., Arnhold, I.J., Latronico, A.C. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  2. Increased GABA(A)-Receptor alpha1-Subunit Expression in Hippocampal Dentate Gyrus after Early-life Status Epilepticus. Raol, Y.H., Zhang, G., Lund, I.V., Porter, B.E., Maronski, M.A., Brooks-Kayal, A.R. Epilepsia (2006) [Pubmed]
  3. Genetic analysis of the GABRA1 gene in patients with essential tremor. Deng, H., Xie, W.J., Le, W.D., Huang, M.S., Jankovic, J. Neurosci. Lett. (2006) [Pubmed]
  4. Mutation screen of GABRA1, GABRB2 and GABRG2 genes in Japanese patients with absence seizures. Ito, M., Ohmori, I., Nakahori, T., Ouchida, M., Ohtsuka, Y. Neurosci. Lett. (2005) [Pubmed]
  5. Absence of GABRA1 Ala322Asp mutation in juvenile myoclonic epilepsy families from India. Kapoor, A., Vijai, J., Ravishankar, H.M., Satishchandra, P., Radhakrishnan, K., Anand, A. J. Genet. (2003) [Pubmed]
  6. No interaction of GABA(A) alpha-1 subunit and dopamine receptor D4 exon 3 genes in symptomatology of major psychoses. Serretti, A., Macciardi, F., Cusin, C., Lattuada, E., Lilli, R., Di Bella, D., Catalano, M., Smeraldi, E. Am. J. Med. Genet. (1999) [Pubmed]
  7. Dopamine receptor D2 and D4 genes, GABA(A) alpha-1 subunit genes and response to lithium prophylaxis in mood disorders. Serretti, A., Lilli, R., Lorenzi, C., Franchini, L., Di Bella, D., Catalano, M., Smeraldi, E. Psychiatry research. (1999) [Pubmed]
  8. Possible association between a haplotype of the GABA-A receptor alpha 1 subunit gene (GABRA1) and mood disorders. Horiuchi, Y., Nakayama, J., Ishiguro, H., Ohtsuki, T., Detera-Wadleigh, S.D., Toyota, T., Yamada, K., Nankai, M., Shibuya, H., Yoshikawa, T., Arinami, T. Biol. Psychiatry (2004) [Pubmed]
  9. Association between GABRA1 and drinking behaviors in the collaborative study on the genetics of alcoholism sample. Dick, D.M., Plunkett, J., Wetherill, L.F., Xuei, X., Goate, A., Hesselbrock, V., Schuckit, M., Crowe, R., Edenberg, H.J., Foroud, T. Alcohol. Clin. Exp. Res. (2006) [Pubmed]
  10. Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy. Cossette, P., Liu, L., Brisebois, K., Dong, H., Lortie, A., Vanasse, M., Saint-Hilaire, J.M., Carmant, L., Verner, A., Lu, W.Y., Wang, Y.T., Rouleau, G.A. Nat. Genet. (2002) [Pubmed]
  11. Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia. Petryshen, T.L., Middleton, F.A., Tahl, A.R., Rockwell, G.N., Purcell, S., Aldinger, K.A., Kirby, A., Morley, C.P., McGann, L., Gentile, K.L., Waggoner, S.G., Medeiros, H.M., Carvalho, C., Macedo, A., Albus, M., Maier, W., Trixler, M., Eichhammer, P., Schwab, S.G., Wildenauer, D.B., Azevedo, M.H., Pato, M.T., Pato, C.N., Daly, M.J., Sklar, P. Mol. Psychiatry (2005) [Pubmed]
  12. GABAA alpha-1 subunit gene not associated with depressive symptomatology in mood disorders. Serretti, A., Macciardi, F., Cusin, C., Lattuada, E., Lilli, R., Di Bella, D., Catalano, M., Smeraldi, E. Psychiatr. Genet. (1998) [Pubmed]
  13. Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting. Song, J., Koller, D.L., Foroud, T., Carr, K., Zhao, J., Rice, J., Nurnberger, J.I., Begleiter, H., Porjesz, B., Smith, T.L., Schuckit, M.A., Edenberg, H.J. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2003) [Pubmed]
  14. Assignment of genes encoding GABAA receptor subunits alpha 1, alpha 6, beta 2, and gamma 2 to a YAC contig of 5q33. Kostrzewa, M., Köhler, A., Eppelt, K., Hellam, L., Fairweather, N.D., Levy, E.R., Monaco, A.P., Müller, U. Eur. J. Hum. Genet. (1996) [Pubmed]
  15. Further evidence for clustering of human GABAA receptor subunit genes: localization of the alpha 6-subunit gene (GABRA6) to distal chromosome 5q by linkage analysis. Hicks, A.A., Bailey, M.E., Riley, B.P., Kamphuis, W., Siciliano, M.J., Johnson, K.J., Darlison, M.G. Genomics (1994) [Pubmed]
 
WikiGenes - Universities