Gene Review:
Hspa5 - heat shock protein 5
Rattus norvegicus
Synonyms:
78 kDa glucose-regulated protein, BIP, BiP, GRP-78, GRP78, ...
- Steroidogenesis-activator polypeptide isolated from a rat Leydig cell tumor. Pedersen, R.C., Brownie, A.C. Science (1987)
- Expression of different members of heat shock protein 70 gene family in liver and hepatomas. Cairo, G., Schiaffonati, L., Rappocciolo, E., Tacchini, L., Bernelli-Zazzera, A. Hepatology (1989)
- Involvement of p38 mitogen-activated protein kinase signaling pathway in the rapid induction of the 78-kDa glucose-regulated protein in 9L rat brain tumor cells. Chen, K.D., Chen, L.Y., Huang, H.L., Lieu, C.H., Chang, Y.N., Chang, M.D., Lai, Y.K. J. Biol. Chem. (1998)
- Interaction of ethanol with inducers of glucose-regulated stress proteins. Ethanol potentiates inducers of grp78 transcription. Hsieh, K.P., Wilke, N., Harris, A., Miles, M.F. J. Biol. Chem. (1996)
- Induction of GRP78 by ischemic preconditioning reduces endoplasmic reticulum stress and prevents delayed neuronal cell death. Hayashi, T., Saito, A., Okuno, S., Ferrand-Drake, M., Chan, P.H. J. Cereb. Blood Flow Metab. (2003)
- OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes. Kondo, S., Murakami, T., Tatsumi, K., Ogata, M., Kanemoto, S., Otori, K., Iseki, K., Wanaka, A., Imaizumi, K. Nat. Cell Biol. (2005)
- Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Bertolotti, A., Zhang, Y., Hendershot, L.M., Harding, H.P., Ron, D. Nat. Cell Biol. (2000)
- Heat shock response of the rat lens. de Jong, W.W., Hoekman, W.A., Mulders, J.W., Bloemendal, H. J. Cell Biol. (1986)
- Rat gene encoding the 78-kDa glucose-regulated protein GRP78: its regulatory sequences and the effect of protein glycosylation on its expression. Chang, S.C., Wooden, S.K., Nakaki, T., Kim, Y.K., Lin, A.Y., Kung, L., Attenello, J.W., Lee, A.S. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Differential display PCR reveals novel targets for the mood-stabilizing drug valproate including the molecular chaperone GRP78. Wang, J.F., Bown, C., Young, L.T. Mol. Pharmacol. (1999)
- Reprogramming of gene expression in postischemic rat liver: induction of proto-oncogenes and hsp 70 gene family. Schiaffonati, L., Rappocciolo, E., Tacchini, L., Cairo, G., Bernelli-Zazzera, A. J. Cell. Physiol. (1990)
- Induction of glucose regulated protein (grp78) and inducible heat shock protein (hsp70) mRNAs in rat brain after kainic acid seizures and focal ischemia. Wang, S., Longo, F.M., Chen, J., Butman, M., Graham, S.H., Haglid, K.G., Sharp, F.R. Neurochem. Int. (1993)
- Regulated expression of GRP78 during vasopressin-induced hypertrophy of heart-derived myocytes. Brostrom, M.A., Mourad, F., Brostrom, C.O. J. Cell. Biochem. (2001)
- Real-time detection and continuous monitoring of ER stress in vitro and in vivo by ES-TRAP: evidence for systemic, transient ER stress during endotoxemia. Hiramatsu, N., Kasai, A., Hayakawa, K., Yao, J., Kitamura, M. Nucleic Acids Res. (2006)
- Degradation and endoplasmic reticulum retention of unassembled alpha- and beta-subunits of Na,K-ATPase correlate with interaction of BiP. Beggah, A., Mathews, P., Beguin, P., Geering, K. J. Biol. Chem. (1996)
- A proteomic screen identified stress-induced chaperone proteins as targets of Akt phosphorylation in mesangial cells. Barati, M.T., Rane, M.J., Klein, J.B., McLeish, K.R. J. Proteome Res. (2006)
- Dendritic and postsynaptic protein synthetic machinery. Gardiol, A., Racca, C., Triller, A. J. Neurosci. (1999)
- Several endoplasmic reticulum stress proteins, including ERp72, interact with thyroglobulin during its maturation. Kuznetsov, G., Chen, L.B., Nigam, S.K. J. Biol. Chem. (1994)
- Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. Karaskov, E., Scott, C., Zhang, L., Teodoro, T., Ravazzola, M., Volchuk, A. Endocrinology (2006)
- Translocation of ATP into the lumen of rough endoplasmic reticulum-derived vesicles and its binding to luminal proteins including BiP (GRP 78) and GRP 94. Clairmont, C.A., De Maio, A., Hirschberg, C.B. J. Biol. Chem. (1992)
- GRP78-binding protein regulates cAMP-induced glial fibrillary acidic protein expression in rat C6 glioblastoma cells. Oh-hashi, K., Hirata, Y., Koga, H., Kiuchi, K. FEBS Lett. (2006)
- Activation of p38 mitogen-activated protein kinase and mitochondrial Ca(2+)-mediated oxidative stress are essential for the enhanced expression of grp78 induced by the protein phosphatase inhibitors okadaic acid and calyculin A. Chen, K.D., Lai, M.T., Cho, J.H., Chen, L.Y., Lai, Y.K. J. Cell. Biochem. (2000)
- The effect of aging on the chaperone concentrations in the hepatic, endoplasmic reticulum of male rats: the possible role of protein misfolding due to the loss of chaperones in the decline in physiological function seen with age. Erickson, R.R., Dunning, L.M., Holtzman, J.L. J. Gerontol. A Biol. Sci. Med. Sci. (2006)
- Mitochondrial calcium-mediated reactive oxygen species are essential for the rapid induction of the grp78 gene in 9L rat brain tumour cells. Chang, W.M., Chen, K.D., Chen, L.Y., Lai, M.T., Lai, Y.K. Cell. Signal. (2003)
- Gene expression analysis in the ventral prostate of rats exposed to vinclozolin or procymidone. Rosen, M.B., Wilson, V.S., Schmid, J.E., Gray, L.E. Reprod. Toxicol. (2005)
- The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro. Dow, G.S., Hudson, T.H., Vahey, M., Koenig, M.L. Malar. J. (2003)
- Protracted lithium treatment protects against the ER stress elicited by thapsigargin in rat PC12 cells: roles of intracellular calcium, GRP78 and Bcl-2. Hiroi, T., Wei, H., Hough, C., Leeds, P., Chuang, D.M. Pharmacogenomics J. (2005)
- Reperfusion causes significant activation of heat shock transcription factor 1 in ischemic rat heart. Nishizawa, J., Nakai, A., Higashi, T., Tanabe, M., Nomoto, S., Matsuda, K., Ban, T., Nagata, K. Circulation (1996)
- The kinetics of steroidogenesis activator polypeptide in the rat adrenal cortex. Effects of adrenocorticotropin, cyclic adenosine 3':5'-monophosphate, cycloheximide, and circadian rhythm. Mertz, L.M., Pedersen, R.C. J. Biol. Chem. (1989)