The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

B4GALNT1  -  beta-1,4-N-acetyl-galactosaminyl...

Homo sapiens

Synonyms: (N-acetylneuraminyl)-galactosylglucosylceramide, Beta-1,4 N-acetylgalactosaminyltransferase 1, GALGT, GALNACT, GM2/GD2 synthase, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of B4GALNT1

 

High impact information on B4GALNT1

 

Biological context of B4GALNT1

 

Anatomical context of B4GALNT1

 

Associations of B4GALNT1 with chemical compounds

 

Other interactions of B4GALNT1

 

Analytical, diagnostic and therapeutic context of B4GALNT1

References

  1. Genomic organization and chromosomal assignment of the human beta1, 4-N-acetylgalactosaminyltransferase gene. Identification of multiple transcription units. Furukawa, K., Soejima, H., Niikawa, N., Shiku, H. J. Biol. Chem. (1996) [Pubmed]
  2. Decreased expression of alpha2,8 sialyltransferase and increased expression of beta1,4 N-acetylgalactosaminyltransferase in gastrointestinal cancers. Koh, Y., Tsunoda, T., Iwahashi, M., Yamaue, H., Ishimoto, K., Tanimura, H., Fukumoto, H., Nakamura, T., Tatsumi, Y., Shimizu, M., Saijo, N., Nishio, K. Exp. Biol. Med. (Maywood) (2002) [Pubmed]
  3. GD2 ganglioside on human T-lymphotropic virus type I-infected T cells: possible activation of beta-1,4-N-acetylgalactosaminyltransferase gene by p40tax. Furukawa, K., Akagi, T., Nagata, Y., Yamada, Y., Shimotohno, K., Cheung, N.K., Shiku, H., Furukawa, K. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  4. Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody. Haraguchi, M., Yamashiro, S., Yamamoto, A., Furukawa, K., Takamiya, K., Lloyd, K.O., Shiku, H., Furukawa, K. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  5. Expression of UDP-GalNAc:NeuAc alpha 2,3Gal beta-R beta 1,4(GalNAc to Gal) N-acetylgalactosaminyltransferase involved in the synthesis of Sda antigen in human large intestine and colorectal carcinomas. Malagolini, N., Dall'Olio, F., Di Stefano, G., Minni, F., Marrano, D., Serafini-Cessi, F. Cancer Res. (1989) [Pubmed]
  6. Association of circulating tumor cells with serum tumor-related methylated DNA in peripheral blood of melanoma patients. Koyanagi, K., Mori, T., O'Day, S.J., Martinez, S.R., Wang, H.J., Hoon, D.S. Cancer Res. (2006) [Pubmed]
  7. Genetic and enzymatic basis for the differential expression of GM2 and GD2 gangliosides in human cancer cell lines. Yamashiro, S., Ruan, S., Furukawa, K., Tai, T., Lloyd, K.O., Shiku, H., Furukawa, K. Cancer Res. (1993) [Pubmed]
  8. Novel poly-GalNAcbeta1-4GlcNAc (LacdiNAc) and fucosylated poly-LacdiNAc N-glycans from mammalian cells expressing beta1,4-N-acetylgalactosaminyltransferase and alpha1,3-fucosyltransferase. Kawar, Z.S., Haslam, S.M., Morris, H.R., Dell, A., Cummings, R.D. J. Biol. Chem. (2005) [Pubmed]
  9. The effects of the site-directed removal of N-glycosylation sites from beta-1,4-N-acetylgalactosaminyltransferase on its function. Haraguchi, M., Yamashiro, S., Furukawa, K., Takamiya, K., Shiku, H., Furukawa, K. Biochem. J. (1995) [Pubmed]
  10. Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate. Uyama, T., Kitagawa, H., Tamura Ji, J., Sugahara, K. J. Biol. Chem. (2002) [Pubmed]
  11. Molecular cloning and characterization of beta1,4-N-acetylgalactosaminyltransferases IV synthesizing N,N'-diacetyllactosediamine. Gotoh, M., Sato, T., Kiyohara, K., Kameyama, A., Kikuchi, N., Kwon, Y.D., Ishizuka, Y., Iwai, T., Nakanishi, H., Narimatsu, H. FEBS Lett. (2004) [Pubmed]
  12. Beta 1,4 N-acetylgalactosaminyltransferase (GM2/GD2/GA2 synthase) forms homodimers in the endoplasmic reticulum: a strategy to test for dimerization of Golgi membrane proteins. Zhu, G., Jaskiewicz, E., Bassi, R., Darling, D.S., Young, W.W. Glycobiology (1997) [Pubmed]
  13. Beta1,4-N-acetylgalactosaminyltransferase (GM2 synthase) is released from Golgi membranes as a neuraminidase-sensitive, disulfide-bonded dimer by a cathepsin D-like protease. Jaskiewicz, E., Zhu, G., Bassi, R., Darling, D.S., Young, W.W. J. Biol. Chem. (1996) [Pubmed]
  14. UDP-GalNAc:NeuAc alpha 2,3Gal beta-R (GalNAc to Gal) beta 1,4-N-acetylgalactosaminyltransferase responsible for the Sda specificity in human colon carcinoma CaCo-2 cell line. Malagolini, N., Dall'Olio, F., Serafini-Cessi, F. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  15. Identification of an endogenous inhibitor of the UDP-N-acetylgalactosamine: GM3, N-acetylgalactosaminyl transferase as apolipoprotein A1. Conde, C.B., Grabois, V.R., Deza, S.N., Caputto, B.L. Neurochem. Res. (1997) [Pubmed]
  16. Cloned beta 1,4 N-acetylgalactosaminyltransferase synthesizes GA2 as well as gangliosides GM2 and GD2. GM3 synthesis has priority over GA2 synthesis for utilization of lactosylceramide substrate in vivo. Lutz, M.S., Jaskiewicz, E., Darling, D.S., Furukawa, K., Young, W.W. J. Biol. Chem. (1994) [Pubmed]
  17. Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc. Sato, T., Gotoh, M., Kiyohara, K., Kameyama, A., Kubota, T., Kikuchi, N., Ishizuka, Y., Iwasaki, H., Togayachi, A., Kudo, T., Ohkura, T., Nakanishi, H., Narimatsu, H. J. Biol. Chem. (2003) [Pubmed]
  18. Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain. Montiel, M.D., Krzewinski-Recchi, M.A., Delannoy, P., Harduin-Lepers, A. Biochem. J. (2003) [Pubmed]
  19. Potential application of ELAVL4 real-time quantitative reverse transcription-PCR for detection of disseminated neuroblastoma cells. Swerts, K., De Moerloose, B., Dhooge, C., Vandesompele, J., Hoyoux, C., Beiske, K., Benoit, Y., Laureys, G., Philippé, J. Clin. Chem. (2006) [Pubmed]
  20. Appearance of beta 1,4 N-acetylgalactosaminyltransferase (glycosphingolipids GA2/GM2/GD2 synthase) in embryonic chicken vitreous humor during development. Allende, M.L., Schwendiman, R.M., Young, W.W. Curr. Eye Res. (1997) [Pubmed]
  21. Molecular cloning of the human beta1,4 N-acetylgalactosaminyltransferase responsible for the biosynthesis of the Sd(a) histo-blood group antigen: the sequence predicts a very long cytoplasmic domain. Lo Presti, L., Cabuy, E., Chiricolo, M., Dall'Olio, F. J. Biochem. (2003) [Pubmed]
 
WikiGenes - Universities