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Gene Review

MRGPRX1  -  MAS-related GPR, member X1

Homo sapiens

Synonyms: GPCR, MGRG2, MRGX1, Mas-related G-protein coupled receptor member X1, SNSR3, ...
 
 
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Disease relevance of MRGPRX1

 

High impact information on MRGPRX1

 

Biological context of MRGPRX1

  • Our data indicate that hSNSR4, when heterologously expressed in rat neurons, can be activated by an opioid-related peptide, couples to G(q/11)-proteins as well as PTX-sensitive G(i/o)-proteins, and modulates neuronal Ca2+ channels, K+ channels, and synaptic transmission [1].
 

Anatomical context of MRGPRX1

  • BAM8-22 (a 15 amino acid C-terminal fragment of bovine adrenal medulla peptide 22), a peptide agonist derived from proenkephalin, inhibited high (but not low) voltage-activated Ca2+ current in both DRG and SCG neurons expressing hSNSR4, whereas no response was detected in control neurons [1].

References

 
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