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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
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Erc2  -  ELKS/RAB6-interacting/CAST family member 2

Rattus norvegicus

Synonyms: CAST, CAST1, CAZ-associated structural protein 1, Cast, Cast1, ...
 
 
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Disease relevance of Cmbp

 

High impact information on Cmbp

  • The AZ in replicated membrane was identified by immunolabeling for CAZ proteins (CAZ-associated structural protein [CAST] and Bassoon) [2].
  • This interaction promotes the localization of syntenin-1 at presynaptic ERC2 clusters [3].
  • Here, we report a novel PDZ [postsynaptic density-95/Discs large/zona occludens-1] interaction between the CAZ protein ERC2/CAST1 and the tandem PDZ protein syntenin-1, which is known to associate with diverse synaptic proteins, including glutamate receptor subunits, SynCAM, and beta-neurexin [3].
  • This finding, combined with the identification of KIAA0378/CAST1 within the synaptic membrane fraction of the spinal cord at the protein level, are consistent with the reported presynaptic localization of CAST, predominantly within the tissue we investigated primarily attributable to primary afferent sensory neurons [1].

References

  1. Analysis of the dorsal spinal cord synaptic architecture by combined proteome analysis and in situ hybridization. Dreger, M., Mika, J., Bieller, A., Jahnel, R., Gillen, C., Schaefer, M.K., Weihe, E., Hucho, F. J. Proteome Res. (2005) [Pubmed]
  2. Differential distribution of release-related proteins in the hippocampal CA3 area as revealed by freeze-fracture replica labeling. Hagiwara, A., Fukazawa, Y., Deguchi-Tawarada, M., Ohtsuka, T., Shigemoto, R. J. Comp. Neurol. (2005) [Pubmed]
  3. Organization of the presynaptic active zone by ERC2/CAST1-dependent clustering of the tandem PDZ protein syntenin-1. Ko, J., Yoon, C., Piccoli, G., Chung, H.S., Kim, K., Lee, J.R., Lee, H.W., Kim, H., Sala, C., Kim, E. J. Neurosci. (2006) [Pubmed]
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