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Gene Review

ctl-1  -  Protein CTL-1

Caenorhabditis elegans

 
 
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Disease relevance of catalase

 

High impact information on catalase

  • A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants [2].
  • The tyrosine hydroxylase-deficient C. elegans mutant (cat-2) also displays these specific behavioral deficits [3].
  • Other life processes, including respiration rate and heat output, remain unaltered over four weeks of diapause at 24 degrees C. Possible determinants of the enhanced life maintenance include increased resistance to oxidative stress provided by enhanced superoxide dismutase and catalase activities, and a shift to a highly reducing redox status [4].
  • Peroxisomes of the pharyngeal gland are larger than those of the gut, but peroxisomes of both tissues contain catalase-2 at similar concentrations [5].
  • Adult nematodes exposed to aminotriazole for 24 h showed catalase activities reduced to less than 20% of controls [6].
 

Biological context of catalase

 

Anatomical context of catalase

  • These results indicate that catalase-2 is peroxisomal and verify that it can be used as a marker enzyme for C. elegans peroxisomes [7].
 

Other interactions of catalase

 

Analytical, diagnostic and therapeutic context of catalase

References

  1. Comparative serial analysis of gene expression of transcript profiles of tomato roots infected with cyst nematode. Uehara, T., Sugiyama, S., Masuta, C. Plant Mol. Biol. (2007) [Pubmed]
  2. A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants. Taub, J., Lau, J.F., Ma, C., Hahn, J.H., Hoque, R., Rothblatt, J., Chalfie, M. Nature (2003) [Pubmed]
  3. Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans. Sanyal, S., Wintle, R.F., Kindt, K.S., Nuttley, W.M., Arvan, R., Fitzmaurice, P., Bigras, E., Merz, D.C., Hébert, T.E., van der Kooy, D., Schafer, W.R., Culotti, J.G., Van Tol, H.H. EMBO J. (2004) [Pubmed]
  4. Ageing is reversed, and metabolism is reset to young levels in recovering dauer larvae of C. elegans. Houthoofd, K., Braeckman, B.P., Lenaerts, I., Brys, K., De Vreese, A., Van Eygen, S., Vanfleteren, J.R. Exp. Gerontol. (2002) [Pubmed]
  5. Peroxisomes of the nematode Caenorhabditis elegans: distribution and morphological characteristics. Yokota, S., Togo, S.H., Maebuchi, M., Bun-Ya, M., Haraguchi, C.M., Kamiryo, T. Histochem. Cell Biol. (2002) [Pubmed]
  6. Haemonchus contortus utilises catalase in defence against exogenous hydrogen peroxide in vitro. Kotze, A.C., McClure, S.J. Int. J. Parasitol. (2001) [Pubmed]
  7. Immunological detection of alkaline-diaminobenzidine-negativeperoxisomes of the nematode Caenorhabditis elegans purification and unique pH optima of peroxisomal catalase. Togo, S.H., Maebuchi, M., Yokota, S., Bun-Ya, M., Kawahara, A., Kamiryo, T. Eur. J. Biochem. (2000) [Pubmed]
  8. A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants. Taub, J., Lau, J.F., Ma, C., Hahn, J.H., Hoque, R., Rothblatt, J., Chalfie, M. Nature (1999) [Pubmed]
  9. The Ginkgo biloba extract EGb761 reduces stress sensitivity, ROS accumulation and expression of catalase and glutathione S-transferase 4 in Caenorhabditis elegans. Kampkötter, A., Pielarski, T., Rohrig, R., Timpel, C., Chovolou, Y., Wätjen, W., Kahl, R. Pharmacol. Res. (2007) [Pubmed]
 
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