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UPF2  -  UPF2 regulator of nonsense transcripts...

Homo sapiens

Synonyms: DKFZP434D222, HUPF2, KIAA1408, Nonsense mRNA reducing factor 2, RENT2, ...
 
 
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High impact information on UPF2

  • For mammalian NMD, current models propose a linear pathway that involves the splicing-dependent deposition of exon-junction complexes (EJCs) and the sequential action of the NMD factors UPF3, UPF2, and UPF1 [1].
  • Nonetheless, hUpf2 is necessary for NMD mediated by tethered Y14 [2].
  • This complex recruits Upf3 and Upf2, which function in nonsense-mediated mRNA decay (NMD) [3].
  • As expected, hUPF2-silenced HeLa cells were impaired in their ability to recognize ectopically expressed aberrant PTC transcripts [4].
  • Upf1/Upf2 Regulation of 3' Untranslated Region Splice Variants of AUF1 Links Nonsense-Mediated and A+U-Rich Element-Mediated mRNA Decay [5].
 

Biological context of UPF2

  • CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells [6].
  • We conclude that a hUPF2-dependent RNA surveillance pathway with translation-like features operating in the nuclear fraction of cells prevents the expression of potentially deleterious truncated proteins encoded by non-productively rearranged TCR genes [7].
 

Anatomical context of UPF2

 

Physical interactions of UPF2

  • In mammals, PTCs are discriminated from physiological stop codons by a process thought to involve the splicing-dependent deposition of an exon junction complex (EJC), EJC-mediated recruitment of Upf3, and Upf2 binding to the N terminus of Upf3 [2].
 

Other interactions of UPF2

 

Analytical, diagnostic and therapeutic context of UPF2

  • Genome-wide DNA microarray expression profiling identified 37 novel up-regulated and 57 down-regulated transcripts in hUPF2-silenced cells [4].
  • Ribonucleoprotein immunoprecipitation experiments revealed that both Upf1 and Upf2 can associate with an NMD-sensitive AUF1 mRNA 3'-UTR variant in cells [5].

References

  1. Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Gehring, N.H., Kunz, J.B., Neu-Yilik, G., Breit, S., Viegas, M.H., Hentze, M.W., Kulozik, A.E. Mol. Cell (2005) [Pubmed]
  2. Y14 and hUpf3b form an NMD-activating complex. Gehring, N.H., Neu-Yilik, G., Schell, T., Hentze, M.W., Kulozik, A.E. Mol. Cell (2003) [Pubmed]
  3. The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. Lejeune, F., Ishigaki, Y., Li, X., Maquat, L.E. EMBO J. (2002) [Pubmed]
  4. hUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay. Wittmann, J., Hol, E.M., Jäck, H.M. Mol. Cell. Biol. (2006) [Pubmed]
  5. Upf1/Upf2 Regulation of 3' Untranslated Region Splice Variants of AUF1 Links Nonsense-Mediated and A+U-Rich Element-Mediated mRNA Decay. Banihashemi, L., Wilson, G.M., Das, N., Brewer, G. Mol. Cell. Biol. (2006) [Pubmed]
  6. CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells. Hosoda, N., Kim, Y.K., Lejeune, F., Maquat, L.E. Nat. Struct. Mol. Biol. (2005) [Pubmed]
  7. A quality control pathway that down-regulates aberrant T-cell receptor (TCR) transcripts by a mechanism requiring UPF2 and translation. Wang, J., Vock, V.M., Li, S., Olivas, O.R., Wilkinson, M.F. J. Biol. Chem. (2002) [Pubmed]
  8. Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). Serin, G., Gersappe, A., Black, J.D., Aronoff, R., Maquat, L.E. Mol. Cell. Biol. (2001) [Pubmed]
  9. Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells. Schell, T., Köcher, T., Wilm, M., Seraphin, B., Kulozik, A.E., Hentze, M.W. Biochem. J. (2003) [Pubmed]
 
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