Gene Review:
UPF2 - UPF2 regulator of nonsense transcripts...
Homo sapiens
Synonyms:
DKFZP434D222, HUPF2, KIAA1408, Nonsense mRNA reducing factor 2, RENT2, ...
- Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Gehring, N.H., Kunz, J.B., Neu-Yilik, G., Breit, S., Viegas, M.H., Hentze, M.W., Kulozik, A.E. Mol. Cell (2005)
- Y14 and hUpf3b form an NMD-activating complex. Gehring, N.H., Neu-Yilik, G., Schell, T., Hentze, M.W., Kulozik, A.E. Mol. Cell (2003)
- The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. Lejeune, F., Ishigaki, Y., Li, X., Maquat, L.E. EMBO J. (2002)
- hUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay. Wittmann, J., Hol, E.M., Jäck, H.M. Mol. Cell. Biol. (2006)
- Upf1/Upf2 Regulation of 3' Untranslated Region Splice Variants of AUF1 Links Nonsense-Mediated and A+U-Rich Element-Mediated mRNA Decay. Banihashemi, L., Wilson, G.M., Das, N., Brewer, G. Mol. Cell. Biol. (2006)
- CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells. Hosoda, N., Kim, Y.K., Lejeune, F., Maquat, L.E. Nat. Struct. Mol. Biol. (2005)
- A quality control pathway that down-regulates aberrant T-cell receptor (TCR) transcripts by a mechanism requiring UPF2 and translation. Wang, J., Vock, V.M., Li, S., Olivas, O.R., Wilkinson, M.F. J. Biol. Chem. (2002)
- Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). Serin, G., Gersappe, A., Black, J.D., Aronoff, R., Maquat, L.E. Mol. Cell. Biol. (2001)
- Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells. Schell, T., Köcher, T., Wilm, M., Seraphin, B., Kulozik, A.E., Hentze, M.W. Biochem. J. (2003)