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Gene Review

CLEC4E  -  C-type lectin domain family 4, member E

Homo sapiens

Synonyms: C-type lectin domain family 4 member E, C-type lectin superfamily member 9, CLECSF9, MINCLE, Macrophage-inducible C-type lectin, ...
 
 
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High impact information on CLEC4E

  • The CLECSF8 gene has been localized on the telomeric region of the NK gene complex on chromosome 12p13 close to MINCLE [1].
  • CLEC4E is predominantly a myeloid receptor, with an unusual reciprocal pattern of expression between monocytes or neutrophils [2].
  • The expression of CLEC4E on monocytes is highly correlated with inflammatory cytokine production TNF in response to the fungal pathogen Candida albicans [2].
  • The expression of CLEC4E on monocytes is inversely correlated with phagocytic uptake or killing of Candida albicans [2].
  • In contrast, the expression of CLEC4E on neutrophils was highly correlated with neutrophil phagocytic uptake or killing of Candida albicans [2].

 

 

 

Interaction partners of CLEC4E

Mincle associates with FcRgamma to activate SYK, CARD9 and the NFkB transcription complex (inferred from mouse). [3]

References

  1. The human C-type lectin CLECSF8 is a novel monocyte/macrophage endocytic receptor. Arce, I., Martínez-Muñoz, L., Roda-Navarro, P., Fernández-Ruiz, E. Eur. J. Immunol. (2004) [Pubmed]
  2. Mincle polarizes human monocyte and neutrophil responses to Candida albicans. Vijayan, D., Radford, K.J., Beckhouse, A.G., Ashman, R.B., Wells, C.A. Immunol. Cell. Biol. (2012) [Pubmed]
  3. Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. Schoenen, H., Bodendorfer, B., Hitchens, K., Manzanero, S., Werninghaus, K., Nimmerjahn, F., Agger, E.M., Stenger, S., Andersen, P., Ruland, J., Brown, G.D., Wells, C., Lang, R. J. Immunol. (2010) [Pubmed]
 
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