Gene Review:
HSPB8 - heat shock 22kDa protein 8
Homo sapiens
Synonyms:
Alpha-crystallin C chain, CMT2L, CRYAC, DHMN2, E2-induced gene 1 protein, ...
Sadoshima,
Boelens,
Radstake,
Dai,
Geurts,
Cai,
Ghaleh,
Aurelian,
Luo,
Hase,
Kulka,
Kudej,
Winchurch,
Chrest,
Zhang,
Xia,
Zhang,
Shen,
Zhang,
Hittinger,
Zhao,
Wang,
Long,
Chen,
Wunderink,
van den Berg,
Schreurs,
Tang,
Vatner,
Depre,
Jiang,
Wagner,
Joosten,
Pan,
Burnett,
Abdollahi-Roodsaz,
Gaussin,
Liu,
Zajac,
Smith,
Gyotoku,
Roelofs,
Yu,
Zaccaro,
- Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis. Roelofs, M.F., Boelens, W.C., Joosten, L.A., Abdollahi-Roodsaz, S., Geurts, J., Wunderink, L.U., Schreurs, B.W., van den Berg, W.B., Radstake, T.R. J. Immunol. (2006)
- Small heat shock protein HspB8: its distribution in Alzheimer's disease brains and its inhibition of amyloid-beta protein aggregation and cerebrovascular amyloid-beta toxicity. Wilhelmus, M.M., Boelens, W.C., Otte-Höller, I., Kamps, B., Kusters, B., Maat-Schieman, M.L., de Waal, R.M., Verbeek, M.M. Acta Neuropathol. (2006)
- Effects of estrogen on global gene expression: identification of novel targets of estrogen action. Charpentier, A.H., Bednarek, A.K., Daniel, R.L., Hawkins, K.A., Laflin, K.J., Gaddis, S., MacLeod, M.C., Aldaz, C.M. Cancer Res. (2000)
- A novel human gene similar to the protein kinase (PK) coding domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) codes for a serine-threonine PK and is expressed in melanoma cells. Smith, C.C., Yu, Y.X., Kulka, M., Aurelian, L. J. Biol. Chem. (2000)
- Forced expression of the H11 heat shock protein can be regulated by DNA methylation and trigger apoptosis in human cells. Gober, M.D., Smith, C.C., Ueda, K., Toretsky, J.A., Aurelian, L. J. Biol. Chem. (2003)
- Overload of the heat-shock protein H11/HspB8 triggers melanoma cell apoptosis through activation of transforming growth factor-beta-activated kinase 1. Li, B., Smith, C.C., Laing, J.M., Gober, M.D., Liu, L., Aurelian, L. Oncogene (2007)
- Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy. Irobi, J., Van Impe, K., Seeman, P., Jordanova, A., Dierick, I., Verpoorten, N., Michalik, A., De Vriendt, E., Jacobs, A., Van Gerwen, V., Vennekens, K., Mazanec, R., Tournev, I., Hilton-Jones, D., Talbot, K., Kremensky, I., Van Den Bosch, L., Robberecht, W., Van Vandekerckhove, J., Broeckhoven, C., Gettemans, J., De Jonghe, P., Timmerman, V. Nat. Genet. (2004)
- Human--rat muscle somatic cell hybrids form myotubes and express human muscle gene products. Quinn, C.A., Goodfellow, P.N., Povey, S., Walsh, F.S. Proc. Natl. Acad. Sci. U.S.A. (1981)
- HspB8, a small heat shock protein mutated in human neuromuscular disorders, has in vivo chaperone activity in cultured cells. Carra, S., Sivilotti, M., Chávez Zobel, A.T., Lambert, H., Landry, J. Hum. Mol. Genet. (2005)
- Immunohistochemical staining for vimentin and keratin in malignant mesothelioma. Churg, A. Am. J. Surg. Pathol. (1985)
- Interactions of HSP22 (HSPB8) with HSP20, alphaB-crystallin, and HSPB3. Fontaine, J.M., Sun, X., Benndorf, R., Welsh, M.J. Biochem. Biophys. Res. Commun. (2005)
- Small heat-shock protein 22 mutated in autosomal dominant Charcot-Marie-Tooth disease type 2L. Tang, B.S., Zhao, G.H., Luo, W., Xia, K., Cai, F., Pan, Q., Zhang, R.X., Zhang, F.F., Liu, X.M., Chen, B., Zhang, C., Shen, L., Jiang, H., Long, Z.G., Dai, H.P. Hum. Genet. (2005)
- Characterization of two novel human small heat shock proteins: protein kinase-related HspB8 and testis-specific HspB9. Kappé, G., Verschuure, P., Philipsen, R.L., Staalduinen, A.A., Van de Boogaart, P., Boelens, W.C., De Jong, W.W. Biochim. Biophys. Acta (2001)
- A novel gene expressed in human keratinocytes with long-term in vitro growth potential is required for cell growth. Aurelian, L., Smith, C.C., Winchurch, R., Kulka, M., Gyotoku, T., Zaccaro, L., Chrest, F.J., Burnett, J.W. J. Invest. Dermatol. (2001)
- Expression analysis and chromosome location of a novel gene (H11) associated with the growth of human melanoma cells. Yu, Y.X., Heller, A., Liehr, T., Smith, C.C., Aurelian, L. Int. J. Oncol. (2001)
- H11 kinase is a novel mediator of myocardial hypertrophy in vivo. Depre, C., Hase, M., Gaussin, V., Zajac, A., Wang, L., Hittinger, L., Ghaleh, B., Yu, X., Kudej, R.K., Wagner, T., Sadoshima, J., Vatner, S.F. Circ. Res. (2002)
- Structural instability caused by a mutation at a conserved arginine in the alpha-crystallin domain of Chinese hamster heat shock protein 27. Chávez Zobel, A.T., Lambert, H., Thériault, J.R., Landry, J. Cell Stress Chaperones (2005)
- Some properties of human small heat shock protein Hsp22 (H11 or HspB8). Kim, M.V., Seit-Nebi, A.S., Marston, S.B., Gusev, N.B. Biochem. Biophys. Res. Commun. (2004)
- Haemonchus contortus glycoproteins contain N-linked oligosaccharides with novel highly fucosylated core structures. Haslam, S.M., Coles, G.C., Munn, E.A., Smith, T.S., Smith, H.F., Morris, H.R., Dell, A. J. Biol. Chem. (1996)
- Crucial role of the H11-H12 loop in stabilizing the active conformation of the human mineralocorticoid receptor. Hellal-Levy, C., Fagart, J., Souque, A., Wurtz, J.M., Moras, D., Rafestin-Oblin, M.E. Mol. Endocrinol. (2000)
- Cellular and molecular biology of aryl hydrocarbon (Ah) receptor-mediated gene expression. Safe, S., Krishnan, V. Arch. Toxicol. Suppl. (1995)
- Small heat shock proteins in inherited peripheral neuropathies. Dierick, I., Irobi, J., De Jonghe, P., Timmerman, V. Ann. Med. (2005)
- Interaction of human HSP22 (HSPB8) with other small heat shock proteins. Sun, X., Fontaine, J.M., Rest, J.S., Shelden, E.A., Welsh, M.J., Benndorf, R. J. Biol. Chem. (2004)
- In vivo modifications of the maize mitochondrial small heat stress protein, HSP22. Lund, A.A., Rhoads, D.M., Lund, A.L., Cerny, R.L., Elthon, T.E. J. Biol. Chem. (2001)
- Identification of Merkel cells in oral epithelium using antikeratin and antineuroendocrine monoclonal antibodies. Ness, K.H., Morton, T.H., Dale, B.A. J. Dent. Res. (1987)