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CNNM1  -  cyclin and CBS domain divalent metal...

Homo sapiens

Synonyms: ACDP1, Ancient conserved domain-containing protein 1, CLP-1, Cyclin-M1, Metal transporter CNNM1
 
 
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Disease relevance of CNNM1

 

High impact information on CNNM1

  • ACDDP, probably manifests its cytotoxicity through the metabolite cis-ammine(cyclohexylamine)dichloroplatinum(II) (ACDP) [1].
  • All ACDP genes except ACDP1 have a ubiquitous expression pattern while ACDP1 expression is restricted to the brain and testis [3].
  • Close parallels have been found between the behaviour of the distortion product 2f1-f2 measured acoustically in the meatus (ACDP) and the 2f1-f2 component (CMDP) measured in the gross cochlear electrical response from the round window during two-tone stimulation [4].
  • By sequence analysis, Mam3p shares strong similarity with the mammalian ACDP (ancient conserved domain protein) family of polypeptides [2].
  • Immunostaining of Acdp1 in hippocampus neurons revealed a predominant localization on the plasma membrane [5].
 

Biological context of CNNM1

  • BACKGROUND: We have recently cloned and characterized a novel gene family named ancient conserved domain protein (ACDP) in humans [5].
  • These results suggest that Acdp is probably a family of proteins involved in ion transport in mammalian cells[5]
  • The mouse Acdp genes showed very strong homologies (>90%) in both nucleotide and amino acid sequences to their human counterparts [5].
  • CONCLUSION: The Acdp genes are evolutionarily conserved in diverse species and ubiquitously expressed throughout development and adult tissues suggesting that Acdp may be an essential gene [5].
 

Anatomical context of CNNM1

  • Acdp showed strong homology to bacteria CorC protein and predominantly localized on the plasma membrane [5].
 

Analytical, diagnostic and therapeutic context of CNNM1

References

  1. Effects of DNA adduct structure and distribution on the mutagenicity and genotoxicity of two platinum anticancer drugs. Yarema, K.J., Wilson, J.M., Lippard, S.J., Essigmann, J.M. J. Mol. Biol. (1994) [Pubmed]
  2. Manganese toxicity and Saccharomyces cerevisiae Mam3p, a member of the ACDP (ancient conserved domain protein) family. Yang, M., Jensen, L.T., Gardner, A.J., Culotta, V.C. Biochem. J. (2005) [Pubmed]
  3. Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP). Wang, C.Y., Shi, J.D., Yang, P., Kumar, P.G., Li, Q.Z., Run, Q.G., Su, Y.C., Scott, H.S., Kao, K.J., She, J.X. Gene (2003) [Pubmed]
  4. Ear canal acoustic and round window electrical correlates of 2f1-f2 distortion generated in the cochlea. Kemp, D.T., Brown, A.M. Hear. Res. (1984) [Pubmed]
  5. Molecular cloning and characterization of the mouse Acdp gene family. Wang, C.Y., Yang, P., Shi, J.D., Purohit, S., Guo, D., An, H., Gu, J.G., Ling, J., Dong, Z., She, J.X. BMC Genomics (2004) [Pubmed]
 
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