Gene Review:
LATS2 - large tumor suppressor kinase 2
Homo sapiens
Synonyms:
KPM, Kinase phosphorylated during mitosis protein, Large tumor suppressor homolog 2, Serine/threonine-protein kinase LATS2, Serine/threonine-protein kinase kpm, ...
- Lats2, a putative tumor suppressor, inhibits G1/S transition. Li, Y., Pei, J., Xia, H., Ke, H., Wang, H., Tao, W. Oncogene (2003)
- The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor. Powzaniuk, M., McElwee-Witmer, S., Vogel, R.L., Hayami, T., Rutledge, S.J., Chen, F., Harada, S., Schmidt, A., Rodan, G.A., Freedman, L.P., Bai, C. Mol. Endocrinol. (2004)
- Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. Takahashi, Y., Miyoshi, Y., Takahata, C., Irahara, N., Taguchi, T., Tamaki, Y., Noguchi, S. Clin. Cancer Res. (2005)
- Downregulation of the large tumor suppressor 2 (LATS2/KPM) gene is associated with poor prognosis in acute lymphoblastic leukemia. Jiménez-Velasco, A., Román-Gómez, J., Agirre, X., Barrios, M., Navarro, G., Vázquez, I., Prósper, F., Torres, A., Heiniger, A. Leukemia (2005)
- Frequent polymorphic changes but rare tumor specific mutations of the LATS2 gene on 13q11-12 in esophageal squamous cell carcinoma. Ishizaki, K., Fujimoto, J., Kumimoto, H., Nishimoto, Y., Shimada, Y., Shinoda, M., Yamamoto, T. Int. J. Oncol. (2002)
- A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Aylon, Y., Michael, D., Shmueli, A., Yabuta, N., Nojima, H., Oren, M. Genes Dev. (2006)
- Separation and evaluation of the covalent and noncovalent interactions which contribute to the binding of pyridoxal 5'-phosphate to D-serine apodehydratase. Schonbeck, N.D., Skalski, M., Shafer, J.A. J. Biol. Chem. (1975)
- LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. Abe, Y., Ohsugi, M., Haraguchi, K., Fujimoto, J., Yamamoto, T. FEBS Lett. (2006)
- Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L). Ke, H., Pei, J., Ni, Z., Xia, H., Qi, H., Woods, T., Kelekar, A., Tao, W. Exp. Cell Res. (2004)
- Determination of structural elements related to the biological activities of a potent decapeptide agonist of human C5a anaphylatoxin. Vogen, S.M., Prakash, O., Kirnarsky, L., Sanderson, S.D., Sherman, S.A. J. Pept. Res. (1999)
- The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Toji, S., Yabuta, N., Hosomi, T., Nishihara, S., Kobayashi, T., Suzuki, S., Tamai, K., Nojima, H. Genes Cells (2004)
- Identifying a region of interest in site- and stage-specific colon cancer on chromosome 13. Sivarajasingham, N.S., Baker, R., Tilsed, J.V., Greenman, J., Monson, J.R., Cawkwell, L. Ann. Surg. Oncol. (2003)