Gene Review:
GREM1 - gremlin 1, DAN family BMP antagonist
Homo sapiens
Synonyms:
C15DUPq, CKTSF1B1, CRAC1, CRCS4, Cell proliferation-inducing gene 2 protein, ...
Namkoong,
Shin,
Kim,
Ha,
Cho,
Hur,
Kim,
Kim,
Koli,
Myllärniemi,
Vuorinen,
Salmenkivi,
Ryynänen,
Kinnula,
Keski-Oja,
Brunkow,
Gardner,
Van Ness,
Paeper,
Kovacevich,
Proll,
Skonier,
Zhao,
Sabo,
Fu,
Alisch,
Gillett,
Colbert,
Tacconi,
Galas,
Hamersma,
Beighton,
Mulligan,
Dolan,
Murphy,
Sadlier,
Lappin,
Doran,
Godson,
Martin,
O'Meara,
Schmid,
Henger,
Kretzler,
Droguett,
Mezzano,
Brady,
- DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers. Suzuki, M., Shigematsu, H., Shames, D.S., Sunaga, N., Takahashi, T., Shivapurkar, N., Iizasa, T., Frenkel, E.P., Minna, J.D., Fujisawa, T., Gazdar, A.F. Br. J. Cancer (2005)
- Transcriptional profiling reveals novel markers of liver fibrogenesis: gremlin and insulin-like growth factor-binding proteins. Boers, W., Aarrass, S., Linthorst, C., Pinzani, M., Elferink, R.O., Bosma, P. J. Biol. Chem. (2006)
- Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis. Koli, K., Myllärniemi, M., Vuorinen, K., Salmenkivi, K., Ryynänen, M.J., Kinnula, V.L., Keski-Oja, J. Am. J. Pathol. (2006)
- Skeletal overexpression of gremlin impairs bone formation and causes osteopenia. Gazzerro, E., Pereira, R.C., Jorgetti, V., Olson, S., Economides, A.N., Canalis, E. Endocrinology (2005)
- An examination of two-process theories of false recognition. Arndt, J., Gould, C. Memory (Hove, England) (2006)
- Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle. Tzahor, E., Kempf, H., Mootoosamy, R.C., Poon, A.C., Abzhanov, A., Tabin, C.J., Dietrich, S., Lassar, A.B. Genes Dev. (2003)
- Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin. Frank, N.Y., Kho, A.T., Schatton, T., Murphy, G.F., Molloy, M.J., Zhan, Q., Ramoni, M.F., Frank, M.H., Kohane, I.S., Gussoni, E. J. Cell Biol. (2006)
- Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. Sneddon, J.B., Zhen, H.H., Montgomery, K., van de Rijn, M., Tward, A.D., West, R., Gladstone, H., Chang, H.Y., Morganroth, G.S., Oro, A.E., Brown, P.O. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy. Dolan, V., Murphy, M., Sadlier, D., Lappin, D., Doran, P., Godson, C., Martin, F., O'Meara, Y., Schmid, H., Henger, A., Kretzler, M., Droguett, A., Mezzano, S., Brady, H.R. Am. J. Kidney Dis. (2005)
- Alteration of fluorouracil metabolism in human colon cancer cells by dipyridamole with a selective increase in fluorodeoxyuridine monophosphate levels. Grem, J.L., Fischer, P.H. Cancer Res. (1986)
- Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose. Kane, R., Stevenson, L., Godson, C., Stitt, A.W., O'Brien, C. The British journal of ophthalmology. (2005)
- Safety assessment of DHA-rich microalgae from Schizochytrium sp. Hammond, B.G., Mayhew, D.A., Naylor, M.W., Ruecker, F.A., Mast, R.W., Sander, W.J. Regulatory toxicology and pharmacology : RTP. (2001)
- Safety assessment of DHA-rich microalgae from Schizochytrium sp. Hammond, B.G., Mayhew, D.A., Kier, L.D., Mast, R.W., Sander, W.J. Regulatory toxicology and pharmacology : RTP. (2002)
- Human cumulus granulosa cell gene expression: a predictor of fertilization and embryo selection in women undergoing IVF. McKenzie, L.J., Pangas, S.A., Carson, S.A., Kovanci, E., Cisneros, P., Buster, J.E., Amato, P., Matzuk, M.M. Hum. Reprod. (2004)
- Lysosomal cathepsins in embryonic programmed cell death. Zuzarte-Luis, V., Montero, J.A., Kawakami, Y., Izpisua-Belmonte, J.C., Hurle, J.M. Dev. Biol. (2007)
- IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1. McMahon, R., Murphy, M., Clarkson, M., Taal, M., Mackenzie, H.S., Godson, C., Martin, F., Brady, H.R. J. Biol. Chem. (2000)
- Unique regulation of SOST, the sclerosteosis gene, by BMPs and steroid hormones in human osteoblasts. Sutherland, M.K., Geoghegan, J.C., Yu, C., Winkler, D.G., Latham, J.A. Bone (2004)
- Gremlin: an example of the re-emergence of developmental programmes in diabetic nephropathy. Lappin, D.W., McMahon, R., Murphy, M., Brady, H.R. Nephrol. Dial. Transplant. (2002)
- Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Brunkow, M.E., Gardner, J.C., Van Ness, J., Paeper, B.W., Kovacevich, B.R., Proll, S., Skonier, J.E., Zhao, L., Sabo, P.J., Fu, Y., Alisch, R.S., Gillett, L., Colbert, T., Tacconi, P., Galas, D., Hamersma, H., Beighton, P., Mulligan, J. Am. J. Hum. Genet. (2001)
- Light- and guanosine 5'-3-O-(thio)triphosphate-sensitive localization of a G protein and its effector on detergent-resistant membrane rafts in rod photoreceptor outer segments. Seno, K., Kishimoto, M., Abe, M., Higuchi, Y., Mieda, M., Owada, Y., Yoshiyama, W., Liu, H., Hayashi, F. J. Biol. Chem. (2001)
- The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein. Namkoong, H., Shin, S.M., Kim, H.K., Ha, S.A., Cho, G.W., Hur, S.Y., Kim, T.E., Kim, J.W. BMC Cancer (2006)
- Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts. Tardif, G., Hum, D., Pelletier, J.P., Boileau, C., Ranger, P., Martel-Pelletier, J. Arthritis Rheum. (2004)
- Bone morphogenetic proteins induce gremlin, a protein that limits their activity in osteoblasts. Pereira, R.C., Economides, A.N., Canalis, E. Endocrinology (2000)
- DRM/GREMLIN (CKTSF1B1) maps to human chromosome 15 and is highly expressed in adult and fetal brain. Topol, L.Z., Modi, W.S., Koochekpour, S., Blair, D.G. Cytogenet. Cell Genet. (2000)
- Spatial segregation of transport and signalling functions between human endothelial caveolae and lipid raft proteomes. Sprenger, R.R., Fontijn, R.D., van Marle, J., Pannekoek, H., Horrevoets, A.J. Biochem. J. (2006)