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Gene Review

NPAS4  -  neuronal PAS domain protein 4

Homo sapiens

Synonyms: BHLHE79, Class E basic helix-loop-helix protein 79, HLH-PAS transcription factor NXF, Le-PAS, NXF, ...
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Disease relevance of NPAS4


High impact information on NPAS4


  1. Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression. Ooe, N., Saito, K., Mikami, N., Nakatuka, I., Kaneko, H. Mol. Cell. Biol. (2004) [Pubmed]
  2. Npas4, a novel helix-loop-helix PAS domain protein, is regulated in response to cerebral ischemia. Shamloo, M., Soriano, L., von Schack, D., Rickhag, M., Chin, D.J., Gonzalez-Zulueta, M., Gido, G., Urfer, R., Wieloch, T., Nikolich, K. Eur. J. Neurosci. (2006) [Pubmed]
  3. Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export. Braun, I.C., Herold, A., Rode, M., Conti, E., Izaurralde, E. J. Biol. Chem. (2001) [Pubmed]
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