Gene Review:
GFPT1 - glutamine--fructose-6-phosphate...
Homo sapiens
Synonyms:
CMSTA1, D-fructose-6-phosphate amidotransferase 1, GFA, GFAT, GFAT 1, ...
- Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase. McKnight, G.L., Mudri, S.L., Mathewes, S.L., Traxinger, R.R., Marshall, S., Sheppard, P.O., O'Hara, P.J. J. Biol. Chem. (1992)
- A novel variant of glutamine: fructose-6-phosphate amidotransferase-1 (GFAT1) mRNA is selectively expressed in striated muscle. DeHaven, J.E., Robinson, K.A., Nelson, B.A., Buse, M.G. Diabetes (2001)
- Phosphorylation of human glutamine:fructose-6-phosphate amidotransferase by cAMP-dependent protein kinase at serine 205 blocks the enzyme activity. Chang, Q., Su, K., Baker, J.R., Yang, X., Paterson, A.J., Kudlow, J.E. J. Biol. Chem. (2000)
- Identification of GFAT1-L, a novel splice variant of human glutamine: fructose-6-phosphate amidotransferase (GFAT1) that is expressed abundantly in skeletal muscle. Niimi, M., Ogawara, T., Yamashita, T., Yamamoto, Y., Ueyama, A., Kambe, T., Okamoto, T., Ban, T., Tamanoi, H., Ozaki, K., Fujiwara, T., Fukui, H., Takahashi, E.I., Kyushiki, H., Tanigami, A. J. Hum. Genet. (2001)
- High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells. Kolm-Litty, V., Sauer, U., Nerlich, A., Lehmann, R., Schleicher, E.D. J. Clin. Invest. (1998)
- Glutamine:fructose-6-phosphate amidotransferase activity in cultured human skeletal muscle cells: relationship to glucose disposal rate in control and non-insulin-dependent diabetes mellitus subjects and regulation by glucose and insulin. Daniels, M.C., Ciaraldi, T.P., Nikoulina, S., Henry, R.R., McClain, D.A. J. Clin. Invest. (1996)
- GFA and S 100 protein levels as an index for malignancy in human gliomas and neurinomas. Jacque, C.M., Kujas, M., Poreau, A., Raoul, M., Collier, P., Racadot, J., Baumann, N. J. Natl. Cancer Inst. (1979)
- Upstream stimulatory factor (USF) proteins induce human TGF-beta1 gene activation via the glucose-response element-1013/-1002 in mesangial cells: up-regulation of USF activity by the hexosamine biosynthetic pathway. Weigert, C., Brodbeck, K., Sawadogo, M., Häring, H.U., Schleicher, E.D. J. Biol. Chem. (2004)
- Increased glutamine:fructose-6-phosphate amidotransferase activity in skeletal muscle of patients with NIDDM. Yki-Järvinen, H., Daniels, M.C., Virkamäki, A., Mäkimattila, S., DeFronzo, R.A., McClain, D. Diabetes (1996)
- The role of glial fibrillary acidic protein in the diagnosis of central nervous system tumors. Deck, J.H., Eng, L.F., Bigbee, J., Woodcock, S.M. Acta Neuropathol. (1978)
- High-throughput functional genomics identifies genes that ameliorate toxicity due to oxidative stress in neuronal HT-22 cells: GFPT2 protects cells against peroxide. Zitzler, J., Link, D., Schäfer, R., Liebetrau, W., Kazinski, M., Bonin-Debs, A., Behl, C., Buckel, P., Brinkmann, U. Mol. Cell Proteomics (2004)
- Molecular screening of the human glutamine-fructose-6-phosphate amidotransferase 1 (GFPT1) gene and association studies with diabetes and diabetic nephropathy. Elbein, S.C., Zheng, H., Jia, Y., Chu, W., Cooper, J.J., Hale, T., Zhang, Z. Mol. Genet. Metab. (2004)
- Glutamine:fructose-6-phosphate aminotransferase enzyme activity is necessary for the induction of TGF-beta1 and fibronectin expression in mesangial cells. Weigert, C., Friess, U., Brodbeck, K., Häring, H.U., Schleicher, E.D. Diabetologia (2003)
- Scrutiny of the glutamine-fructose-6-phosphate transaminase 1 (GFPT1) locus reveals conserved haplotype block structure not associated with diabetic nephropathy. Ng, D.P., Walker, W.H., Chia, K.S., Choo, S., Warram, J.H., Krolewski, A.S. Diabetes (2004)
- Effect of +36T > C in intron 1 on the glutamine: fructose-6-phosphate amidotransferase 1 gene and its contribution to type 2 diabetes in different populations. Kunika, K., Tanahashi, T., Kudo, E., Mizusawa, N., Ichiishi, E., Nakamura, N., Yoshikawa, T., Yamaoka, T., Yasumo, H., Tsugawa, K., Moritani, M., Inoue, H., Itakura, M. J. Hum. Genet. (2006)
- Coordinated regulation of glutamine:fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine. Role of hexosamine biosynthesis in enzyme regulation. Traxinger, R.R., Marshall, S. J. Biol. Chem. (1991)
- Common variants in glutamine:fructose-6-phosphate amidotransferase 2 (GFPT2) gene are associated with type 2 diabetes, diabetic nephropathy, and increased GFPT2 mRNA levels. Zhang, H., Jia, Y., Cooper, J.J., Hale, T., Zhang, Z., Elbein, S.C. J. Clin. Endocrinol. Metab. (2004)
- Effect of sucrose and saturated-fat diets on mRNA levels of genes limiting muscle fatty acid and glucose supply in rats. Ferrer-Martínez, A., Marotta, M., Turini, M., Macé, K., Gómez-Foix, A.M. Lipids (2006)
- Kinetic characterization of human glutamine-fructose-6-phosphate amidotransferase I: potent feedback inhibition by glucosamine 6-phosphate. Broschat, K.O., Gorka, C., Page, J.D., Martin-Berger, C.L., Davies, M.S., Huang Hc, H.C., Gulve, E.A., Salsgiver, W.J., Kasten, T.P. J. Biol. Chem. (2002)
- Expression of glutamine:fructose-6-phosphate amidotransferase in human tissues: evidence for high variability and distinct regulation in diabetes. Nerlich, A.G., Sauer, U., Kolm-Litty, V., Wagner, E., Koch, M., Schleicher, E.D. Diabetes (1998)
- Role of the hexosamine biosynthetic pathway in diabetic nephropathy. Schleicher, E.D., Weigert, C. Kidney Int. Suppl. (2000)