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Gene Review

pColE1_25  -  colicin E1 protein (cea)

Escherichia coli

 
 
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Disease relevance of cea

  • The data suggest that mitomycin C-induced bidirectional transcription from the cea mRNA and RNA-C promoters is controlled by the SOS regulatory system of Escherichia coli [1].
 

High impact information on cea

  • We analyzed the structural and functional relationships among independently cloned segments of the plasmid ColE1 region that regulates and codes for colicin E1 (cea), immunity (imm), and the mitomycin C-induced lethality function (lys) [2].
  • Structural and functional organization of the colicin E1 operon [2].
  • Cleavage maps of colicin E1 plasmid DNA and its smaller derivative, pNT1 DNA, were constructed by using restriction endonucleases [3].
  • The site of the nucleotide from which DNA replication is initiated was determined with 6S L-fragments, the DNA fragment first made on colicin E1 plasmid DNA [3].
  • Helix 1 of the membrane-associated closed state of the colicin E1 channel domain was studied by site-directed fluorescence labeling where bimane was covalently attached to a single cysteine residue in each mutant protein [4].
 

Biological context of cea

 

Anatomical context of cea

 

Associations of cea with chemical compounds

 

Other interactions of cea

 

Analytical, diagnostic and therapeutic context of cea

References

  1. Mitomycin C-induced bidirectional transcription from the colicin E1 promoter region in plasmid ColE1. Parker, R.C. Biochim. Biophys. Acta (1986) [Pubmed]
  2. Structural and functional organization of the colicin E1 operon. Waleh, N.S., Johnson, P.H. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  3. Origin of replication of colicin E1 plasmid DNA. Tomizawa, J.I., Ohmori, H., Bird, R.E. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  4. Scanning the membrane-bound conformation of helix 1 in the colicin E1 channel domain by site-directed fluorescence labeling. Musse, A.A., Wang, J., Deleon, G.P., Prentice, G.A., London, E., Merrill, A.R. J. Biol. Chem. (2006) [Pubmed]
  5. Regulation of gene expression in plasmid ColE1: delayed expression of the kil gene. Zhang, S.P., Yan, L.F., Zubay, G. J. Bacteriol. (1988) [Pubmed]
  6. The nucleotide sequence surrounding the promoter region of colicin E1 gene. Ebina, Y., Kishi, F., Miki, T., Kagamiyama, H., Nakazawa, T., Nakazawa, A. Gene (1981) [Pubmed]
  7. Overproduction and purification of the colicin E1 immunity protein. Shirabe, K., Yamada, M., Merrill, A.R., Cramer, W.A., Nakazawa, A. Plasmid (1993) [Pubmed]
  8. Plasmid-encoded regulation of colicin E1 gene expression. Ebina, Y., Takahara, Y., Shirabe, K., Yamada, M., Nakazawa, T., Nakazawa, A. J. Bacteriol. (1983) [Pubmed]
  9. Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. Bolivar, F., Rodriguez, R.L., Greene, P.J., Betlach, M.C., Heyneker, H.L., Boyer, H.W. Gene (1977) [Pubmed]
  10. Differential scanning calorimetric and theoretical studies of ColE1 DNA. Maeda, Y., Ohtsubo, E. Nucleic Acids Symp. Ser. (1986) [Pubmed]
  11. Mobilization of the Escherichia coli plasmid ColE1 (colicin E1) and ColE1 vectors used in recombinant DNA experiments. Dougan, G., Crosa, J.H., Falkow, S. J. Infect. Dis. (1978) [Pubmed]
 
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